4'-Hydroxyacetophenone
- CAS No.
- 99-93-4
- Chemical Name:
- 4'-Hydroxyacetophenone
- Synonyms
- 4-HYDROXYACETOPHENONE;Piceol;P-HYDROXYACETOPHENONE;POB;P-HYDROXYBENZOPHENONE;ACETYLPHENOL;p-Acetylphenol;4-Hydroksyacetofenol;4-HYDROXYLACETOPHENONE;para-Hydroxyacetophenone
- CBNumber:
- CB7198612
- Molecular Formula:
- C8H8O2
- Molecular Weight:
- 136.15
- MOL File:
- 99-93-4.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/5/21 8:26:20
| Melting point | 132-135 °C(lit.) |
|---|---|
| Boiling point | 147-148 °C3 mm Hg(lit.) |
| Density | 1.109 |
| vapor pressure | 0.002Pa at 20℃ |
| refractive index | 1.5577 (estimate) |
| FEMA | 4330 | 4-HYDROXYACETOPHENONE |
| Flash point | 166 °C |
| storage temp. | Store below +30°C. |
| solubility | methanol: 0.1 g/mL, clear |
| form | Crystalline Powder |
| pka | 8.05(at 25℃) |
| color | Almost white to beige |
| Specific Gravity | 1.109 |
| Odor | at 10.00 % in dipropylene glycol. mild sweet hawthorn balsam mimosa |
| Odor Type | floral |
| Water Solubility | 10 g/L (22 ºC) |
| JECFA Number | 2040 |
| BRN | 774355 |
| InChIKey | TXFPEBPIARQUIG-UHFFFAOYSA-N |
| LogP | 1.35 at 25℃ |
| CAS DataBase Reference | 99-93-4(CAS DataBase Reference) |
| NIST Chemistry Reference | Acetophenone, 4'-hydroxy-(99-93-4) |
| EPA Substance Registry System | 4-Hydroxyacetophenone (99-93-4) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H319-H412 | |||||||||
| Precautionary statements | P264-P273-P280-P305+P351+P338-P337+P313-P501 | |||||||||
| Hazard Codes | Xn,Xi | |||||||||
| Risk Statements | 36/37/38-22 | |||||||||
| Safety Statements | 26-36/37-37/39-24/25-22-36 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | PC4959775 | |||||||||
| Hazard Note | Irritant | |||||||||
| TSCA | Yes | |||||||||
| HS Code | 29145000 | |||||||||
| NFPA 704 |
|
4'-Hydroxyacetophenone price More Price(19)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | PHR1971 | Acetaminophen Impurity E Pharmaceutical Secondary Standard; Certified Reference Material | 99-93-4 | 100MG | ₹45378.4 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 8.04311 | 4′-Hydroxyacetophenone for synthesis | 99-93-4 | 100G | ₹4660 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 98837 | 4′-Hydroxyacetophenone analytical standard | 99-93-4 | 100MG | ₹6365.1 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 8.04311 | 4′-Hydroxyacetophenone for synthesis | 99-93-4 | 250G | ₹9710.01 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 278564 | 4′-Hydroxyacetophenone 99% | 99-93-4 | 5G | ₹3236.68 | 2022-06-14 | Buy |
4'-Hydroxyacetophenone Chemical Properties,Uses,Production
Chemical Properties
almost white to beige crystalline powder
Occurrence
Reported found in cloudberry, coffee, cranberry, mango, sherry, and wort.
Uses
4?-Hydroxyacetophenone has been used as ketone component in the preparation of 1-aryl-3-phenethylamino-1-propanone hydrochlorides, potential cytotoxic agents, via Mannich reactions.
Preparation
Preparation by Fries rearrangement of phenyl acetate with Lewis acids
aluminium chloride
in nitrobenzene at 20–25° or at 50–60°
in chlorobenzene between 45° and 65°, sealed tube and subjected to high power microwave irradiation for 2 min only (36%)
in nitroethane at 60° (44%)
in carbon disulfide at 45° (40%)
in petroleum ether at 50° (20%)
but between 130° and 175° (40–60%)
aluminium chloride–sodium chloride mixture at 240–250° (10%)
boron trifluoride at 90° (56%)
scandium tris(trifluoromethanesulfonate), in nitromethane, at 50° (39%)
titanium tetrachloride at 90–100° (34%)
ferric chloride at 65° (25%)
zinc chloride at 125° (8%)
hydrofluoric acid, between 20° and 100° (94%)
polyphosphoric acid, between 20° and 100° (69%) (50–53%)(44%)
Nafion-XR 500, sulfonic acid type at 100°
ZSM-5, in sulfolane, at 180° (28%)
H-ZSM-5 at 400° or at 210° (6%)
H-Nu-2 at 170° (15%)
HY (Si/Al = 3) or fluorided alumina (Al2O3-F; 3 % wt. F), at 400°.
Definition
ChEBI: A monohydroxyacetophenone carrying a hydroxy substituent at position 4'.
General Description
Pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards
Purification Methods
Crystallise it from diethyl ether, aqueous EtOH or *benzene/pet ether. [Beilstein 8 H 87, 8 IV 339.]
4'-Hydroxyacetophenone Preparation Products And Raw materials
Raw materials
Preparation Products
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| SAGAR LIFE SCIENCES PVT LTD | 58 |
| STELLENCE PHARMSCIENCE PVT TLD | 58 |
| JSK Chemicals | 58 |
| KARPSCHEM LABORATORIES | 58 |
| SODIUM METAL PVT LTD | 58 |
| CNS CHEMICALS | 58 |
| Clarion Drugs Ltd | 58 |
| BASF India Limited | 58 |
| Orgamine Chemicals(I) Pvt Ltd | 58 |
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