N-(6-Bromoimidazo[1,2-a]pyridin-2-yl)cyclopropanecarboxamide 化学特性,用途語,生産方法
合成
To a solution of 6-Bromoimidazo[1,2-a]pyridin-2-amine (73 g, 346 mmol) in CH2Cl2 (1.5 L) was added Et3N (42 g, 415 mmol). Cyclopropanecarbonyl chloride (41 g, 398 mmol) in CH2Cl2 (100 mL) was added dropwise at 0 C. After the addition was complete, the mixture was warmed to room temperature and stirred for 3 h. After the reaction was complete according to TLC, saturated K2CO3 solution (100 mL) was added to quench the reaction. The mixture was stirred for 2h. Yellow solids crushed out of the mixture were collected by filtration and dried to provide N-(6-Bromoimidazo[1,2-a]pyridin-2-yl)cyclopropanecarboxamide as a yellow solid (97 g, 99%)
N-(6-Bromoimidazo[1,2-a]pyridin-2-yl)cyclopropanecarboxamide 上流と下流の製品情報
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