ロサルタンカルボキシアルデヒド

ロサルタンカルボキシアルデヒド 化学構造式
114798-36-6
CAS番号.
114798-36-6
化学名:
ロサルタンカルボキシアルデヒド
别名:
ロサルタンカルボキシアルデヒド
英語名:
Losartan Carboxaldehyde
英語别名:
DUP 167;EXP 3179;Losartan Aldehyde;Losartan EP IMpurity K;Losartan Carboxaldehyde;Losartan Impurity K (EP);Losartan Carboxaldehyde-d3;Losartan Related CoMpound C;Losartan USP Related Compound C;Allisartan Isoproxil impurity II
CBNumber:
CB01176401
化学式:
C22H21ClN6O
分子量:
420.89
MOL File:
114798-36-6.mol

ロサルタンカルボキシアルデヒド 物理性質

融点 :
84-86°C
沸点 :
666.7±65.0 °C(Predicted)
比重(密度) :
1.34±0.1 g/cm3(Predicted)
貯蔵温度 :
Refrigerator, Under Inert Atmosphere
溶解性:
クロロホルム(微量)、エタノール(微量)、メタノール(微量)
外見 :
個体
酸解離定数(Pka):
4.16±0.10(Predicted)
色:
オフホワイトからライトイエロー
CAS データベース:
114798-36-6

安全性情報

HSコード  2933290000

ロサルタンカルボキシアルデヒド 価格 もっと(2)

メーカー 製品番号 製品説明 CAS番号 包装 価格 更新時間 購入
富士フイルム和光純薬株式会社(wako) W01TRCL470505 ロサルタンカルボキシアルデヒド
Losartan Carboxaldehyde
114798-36-6 10mg ¥53400 2024-03-01 購入
富士フイルム和光純薬株式会社(wako) W01TRCL470505 ロサルタンカルボキシアルデヒド
Losartan Carboxaldehyde
114798-36-6 100mg ¥416700 2024-03-01 購入

ロサルタンカルボキシアルデヒド 化学特性,用途語,生産方法

説明

Losartan carboxaldehyde is an intermediate aldehyde metabolite of the angiotensin II type 1 receptor antagonist, losartan . It does not block angiotensin receptors, but instead inhibits endothelial cyclooxygenase (COX)-2 expression, thereby exerting anti-inflammatory actions. At 1 μM in vitro, losartan carboxaldehyde has also been shown to block the upregulation of intercellular adhesion molecule (ICAM)-1 mRNA and COX-dependent generation of thromboxane A2 and prostaglandin F . Losartan carboxaldehyde can also act as a partial agonist (EC50 = 17.1 μM) of the insulin-sensitizing peroxisome proliferator-activated receptor γ in vitro.

化学的特性

Yellow Solid

使用

Losartan carboxaldehyde is an intermediate aldehyde metabolite of the angiotensin II type 1 receptor antagonist, losartan . It does not block angiotensin receptors, but instead inhibits endothelial cyclooxygenase (COX)-2 expression, thereby exerting anti-inflammatory actions. At 1 μM in vitro, losartan carboxaldehyde has also been shown to block the upregulation of intercellular adhesion molecule (ICAM)-1 mRNA and COX-dependent generation of thromboxane A2 and prostaglandin F2α . Losartan carboxaldehyde can also act as a partial agonist (EC50 = 17.1 μM) of the insulin-sensitizing peroxisome proliferator-activated receptor γ in vitro.[Cayman Chemical]

ロサルタンカルボキシアルデヒド 上流と下流の製品情報

原材料

準備製品


ロサルタンカルボキシアルデヒド 生産企業

Global( 77)Suppliers
名前 電話番号 電子メール 国籍 製品カタログ 優位度
Amadis Chemical Company Limited
571-89925085
sales@amadischem.com China 131981 58
Hangzhou FandaChem Co.,Ltd.
008657128800458; +8615858145714
fandachem@gmail.com China 9352 55
Standardpharm Co. Ltd.
86-714-3992388
overseasales1@yongstandards.com United States 14336 58
BOC Sciences
+1-631-485-4226
inquiry@bocsci.com United States 19553 58
Zhengzhou Alfa Chemical Co.,Ltd
+8618530059196
sale04@alfachem.cn China 12478 58
Career Henan Chemica Co
+86-0371-86658258 15093356674;
laboratory@coreychem.com China 30255 58
HANGZHOU CLAP TECHNOLOGY CO.,LTD
86-571-88216897,88216896 13588875226
sales@hzclap.com CHINA 6313 58
sgtlifesciences pvt ltd
+8617013299288
dj@sgtlifesciences.com China 12382 58
Alfa Chemistry
+1-5166625404
Info@alfa-chemistry.com United States 21317 58
Nanjing Doge Biomedical Technology Co., Ltd
+86-25-58227606 +86-15305155328
sales@dogechemical.com China 4128 58

114798-36-6(ロサルタンカルボキシアルデヒド)キーワード:


  • 114798-36-6
  • 2-Butyl-4-chloro-1-[[2(1H-tetrazol-5-yl)[1,1biphenyl]-4-yl]methyl]-1H-imidazole-5-carboxaldehyde
  • DUP 167
  • EXP 3179
  • Losartan Carboxaldehyde Discontinued see product # L470505
  • Losartan Carboxaldehyde
  • 2-(Butyl-d3)-4-chloro-1-[[2(1H-tetrazol-5-yl)[1,1biphenyl]-4-yl]methyl]-1H-imidazole-5-carboxaldehyde
  • Losartan Carboxaldehyde-d3
  • Losartan EP IMpurity K (LosaratnCarboxaldehyde)
  • Losartan EP IMpurity K
  • Losartan Related CoMpound C
  • Losartan Aldehyde
  • 1-((2'-(1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methyl)-2-butyl-4-chloro-1H-imidazole-5-carbaldehyde
  • Losartan Related Compound C (2-Butyl-4-chloro-1-[[2''-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl]-1H-imi (1370495)
  • Losartan Carboxaldehyde_x000b_Discontinued see product # L470505
  • Losartan EP Impurity K/ Losartan Related Compound C (Losartan Aldehyde)
  • Allisartan Isoproxil impurity II
  • 1H-Imidazole-5-carboxaldehyde, 2-butyl-4-chloro-1-[[2'-(2H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-
  • Losartan EP Impurity K:Losartan Impurity K
  • Losartan Impurity 11(Losartan EP Impurity K)
  • 2-Butyl-4-chloro-1-[p-(o-1H-tetrazol-5-ylphenyl)benzyl]imidazole-5-formaldehyde
  • Losartan Impurity K (EP)
  • 2-butyl-5-chloro-3-[[4-[2-(2H-tetrazol-5-yl)phenyl]phenyl]methyl]imidazole-4-carbaldehyde
  • Losartan EP Impurity K (Losartan Carboxaldehyde)
  • Losartan USP Related Compound C
  • DuP 167,EXP-3179,DuP-167,Inhibitor,COX,AT1-R–blocking,intermediate aldehyde metabolite,Cyclooxygenase,COX-2,EXP3179,inhibit,EXP 3179,Losartan,Losartan Carboxaldehyde,anti-inflammatory,DuP167
  • Losartan Potassium EP Impurity K
  • Losartan EP Impurity K (Losartan USP Related Compound C, Losartan Carboxaldehyde)
  • Losartan EP Impurity K Losartan USP RC C
  • ロサルタンカルボキシアルデヒド
Copyright 2017 © ChemicalBook. All rights reserved