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補酵素Q10

補酵素Q10 化学構造式
303-98-0
CAS番号.
303-98-0
化学名:
補酵素Q10
别名:
補酵素Q10;コエンザイムQ10;トリデミン;ソラネキノン;ラコビール;2-[(2E,6E,10E,14E,18E,22E,26E,30E,34E)-3,7,11,15,19,23,27,31,35,39-デカメチル-2,6,10,14,18,22,26,30,34,38-テトラコンタデカエニル]-5,6-ジメトキシ-3-メチル-2,5-シクロヘキサジエン-1,4-ジオン;アデリール;サンキノン;2-[(2E,6E,10E,14E,18E,22E,26E,30E,34E)-3,7,11,15,19,23,27,31,35,39-デカメチル-2,6,10,14,18,22,26,30,34,38-テトラコンタンデカエニル]-5,6-ジメトキシ-3-メチル-2,5-シクロヘキサジエン-1,4-ジオン;5,6-ジメトキシ-3-メチル-2-[(2E,6E,10E,14E,18E,22E,26E,30E,34E)-3,7,11,15,19,23,27,31,35,39-デカメチル-2,6,10,14,18,22,26,30,34,38-テトラコンタデカエニル]-2,5-シクロヘキサジエン-1,4-ジオン;ユベ·Q;ヨウビキノン;ユビキノンQ10;2,3-ジメトキシ-5-[(2E,6E,10E,14E,18E,22E,26E,30E,34E)-3,7,11,15,19,23,27,31,35,39-デカメチルテトラコンタン-2,6,10,14,18,22,26,30,34,38-デカエン-1-イル]-6-メチル-1,4-ベンゾキノン;デカソフト;ウビキノン50;ユビキノン;ユベキノン;2-[(2E,6E,10E,14E,18E,22E,26E,30E,34E)-3,7,11,15,19,23,27,31,35,39-デカメチル-2,6,10,14,18,22,26,30,34,38-テトラコンタデカエニル]-5,6-ジメトキシ-3-メチル-p-ベンゾキノン;イノキテン
英語化学名:
Ubidecarenone
英語别名:
Q-10;Coen;Q-Gel;COQ10;Ensorb;AquaQ10;Cudesan;Coenz10;Kudesan;CoQ10-d6
CBNumber:
CB0121840
化学式:
C59H90O4
分子量:
863.34
MOL File:
303-98-0.mol

補酵素Q10 物理性質

融点 :
49-51 °C
沸点 :
715.32°C (rough estimate)
比重(密度) :
0.9145 (rough estimate)
屈折率 :
1.4760 (estimate)
貯蔵温度 :
-20°C
溶解性:
Soluble in chloroform.
外見 :
neat
Sensitive :
Light Sensitive
Merck :
14,9843
BRN :
1900141
安定性::
Stable, but may be light or heat sensitive. Store in the dark at -20 C. Incompatible with strong oxidizing agents.
InChIKey:
ACTIUHUUMQJHFO-DQXDOXBUSA-N
CAS データベース:
303-98-0(CAS DataBase Reference)
EPAの化学物質情報:
Ubidecarenone (303-98-0)

安全性情報

主な危険性  Xi
Rフレーズ  36/37/38
Sフレーズ  22-24/25-26
WGK Germany  3
RTECS 番号 DK3900000
8-10
TSCA  Yes
HSコード  29146990
毒性 LD50 intramuscular in mouse: > 500mg/kg

補酵素Q10 価格 もっと(35)

メーカー 製品番号 製品説明 CAS番号 包装 価格 更新時間 購入
富士フイルム和光純薬株式会社(wako) W01CHDASB-00003701 補酵素Q10(Natural)
Coenzyme Q10(Natural)
303-98-0 5mg ¥12700 2021-03-23 購入
富士フイルム和光純薬株式会社(wako) W01CHDASB-00003701 補酵素Q10(Natural)
Coenzyme Q10(Natural)
303-98-0 25mg ¥15900 2021-03-23 購入
東京化成工業 C1971 補酵素Q10 >98.0%(HPLC)
Coenzyme Q10 >98.0%(HPLC)
303-98-0 100mg ¥3100 2021-03-23 購入
東京化成工業 C1971 補酵素Q10 >98.0%(HPLC)
Coenzyme Q10 >98.0%(HPLC)
303-98-0 1g ¥15600 2021-03-23 購入
関東化学株式会社(KANTO) 07215-62 補酵素Q10 >97.0%(HLC)
Coenzyme Q10 >97.0%(HLC)
303-98-0 1g ¥16500 2021-03-23 購入

補酵素Q10 化学特性,用途語,生産方法

外観

黄色〜黄赤色, 粉末又は塊

定義

本品は、次の化学式で表される芳香族ケトンである。

溶解性

多くの有機溶媒に易溶。ベンゼンに易溶、エタノールに難溶、水に不溶。水,メタノール,エタノールにほとんど不溶、クロロホルム,ヘキサン,エーテルに易溶、アセトンにやや可溶。

用途

HPLCによるユビキノン10定量用標準品。

用途

細胞内ミトコンドリアのエネ ルギー補酵素として作用します。

用途

細胞内ミトコンドリアのエネ ルギー補酵素として作用します。

用途

薬理研究用。

化粧品の成分用途

保湿.湿潤剤、皮膚コンディショニング剤、皮膚保護剤、酸化防止剤

効能

強心薬, 補酵素, ATP産生賦活薬

商品名

ノイキノン (エーザイ); ユビデカレノン (日新製薬-山形)

化学的特性

Yellow-Orange Crystalline Powder

Originator

Neuquinon,Eisai,Japan,1974

天然物の起源

Coenzyme Q10 is found in dietary sources.

使用

Ubidecarenone is also known as coenzyme Q10 it is a powerful antioxidant that is naturally found in the cells. It acts as a free radical neutraliser.

使用

Antibacterial and antioxidant for preventing and treating cancer.

使用

Coenzyme Q10 (CoQ10) is a naturally occurring quinone found throughout the body in cell membranes, primarily in mitochondrial membranes, with highest concentrations in the heart, lungs, liver, kidneys, spleen, pancreas, and adrenal glands. It is a component of the electron transport chain and participates in aerobic cellular respiration, generating energy in the form of ATP. In its reduced form, CoQ10 acts as an antioxidant, preventing the formation of reactive oxygen species. CoQ10 deficiencies have been associated with heart failure, hypertension, parkinsonism, mitochondrial encephalomyopathies, and other chronic diseases.[Cayman Chemical]

定義

Found in animal organs and yeast. Active in the citric acid cycle in carbohydrate metabolism. The n in the formula varies according to the source.

定義

ubiquinone: Any of a group of relatedquinone-derived compoundsthat serve as electron carriers in theelectron transport chain reactionsof cellular respiration. Coenzyme Qmolecules have side chains of differentlengths in different types of organismsbut function in similar ways.

Manufacturing Process

A small fermentation tank (5,000 parts by volume capacity) was charged with 3,000 parts by volume of a culture medium (pH 6.0) comprising 3% glucose, 1% polypepton, 0.5% yeast extract and 0.5% malt extract. The medium was sterilized by heating in a conventional manner and cooled. This medium was inoculated with 150 parts by volume of a pre-culture of Sporidiobolus ruinenii CBS-5001, which had been prepared by growing the same strain on a medium of the same composition as above at 28°C for one day. The inoculated medium was incubated at 28°C and under agitation at 800 rpm with sparging at a rate of 3,000 parts by volume per minute for 24 hours. During this fermentation period, the medium was maintained at pH 6.0 with ammonia and sulfuric acid.
The resultant fermentation broth was centrifuged to harvest the microbial cells, and they were washed with water and centrifuged a second time, whereupon a living cell paste was obtained. (There was obtained an amount of cells equivalent to 54 parts on a dry basis, which contained 920 μg of ubiquinone-10 per gram of dry cells.)
The moist cells were suspended in 750 parts of volume of ethanol and extracted by warming at 60°C for 1 hour. A total of 3 extractions were carried out in a similar manner and the extracts were pooled, diluted with water and further extracted three times with 1,000 parts of volume portions of n_x0002_hexane. The n-hexane layer was concentrated to dryness under reduced pressure to recover 4.12 parts of a yellow oil. This oily residue was dissolved in 6 parts by volume of benzene and passed through a column (500 parts by volume capacity) packed with Floridil (100 to 200 meshes). Elution was carried out using benzene and the eluate was collected in 10 parts by volume fractions. Each fraction was analyzed by thin-layer chromatography and color reaction and the fractions rich in ubiquinone-10 were pooled and concentrated under reduced pressure. By this procedure was obtained 0.562 part of a yellow oil. This product was dissolved in 5 parts by volume of chloroform, coated onto a thin layer plate of silica gel GF254 (silica gel with calcium sulfate) and developed with benzene. The fractions corresponding to ubiquinone-10 were extracted, whereby 0.054 part of a yellow oil was obtained. This oil was dissolved in 10 parts by volume of ethanol and allowed to cool, whereupon 0.029 part of yellow crystals of ubiquinone-10 were obtained, its melting point 48° to 50°C.
There are also synthetic routes to the ubiquinones as described in US Patents 3,068,295; 3,896,153 and 4,062,879.

Therapeutic Function

UBIDECARENONE

生物活性

Component of the mitochondrial transporter chain that behaves as a powerful antioxidant. Displays neuroprotective activity.

純化方法

Purify it by recrystallisation from EtOH, EtOH/Me2CO or Et2O/EtOH and by chromatography on silica gel using isoPrOH/Et2O (3:1) to give orange crystals. It has max 270nm ( 15,170) in pet ether. [Terao et al. J Org Chem 44 868 1979, NMR and MS: Naruta et al. J Org Chem 45 4097 1980, IR: Lester et al. Biochem Biophys Acta 42 1278 1959, NMR: Planta et al. Helv Chim Acta 42 1278 1959; Morton Biochemical Spectroscopy (Adam Hilger, London, 1975) p 491].

補酵素Q10 上流と下流の製品情報

原材料

準備製品


補酵素Q10 生産企業

Global( 622)Suppliers
名前 電話番号 ファックス番号 電子メール 国籍 製品カタログ 優位度
Xi'an Kono chem co., Ltd.,
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info@konochemical.com CHINA 3000 58
Shaanxi Pioneer Biotech Co., Ltd .
86-13259417953(Whatsapp/Wechat) 86-13259417953(Whatsapp)
029-84385017 sales@pioneerbiotech.com CHINA 3001 58
Hebei Henghe Import and Export Trading Co. LTD
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HONG KONG IPURE BIOLOGY CO.,LIMITED
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XI'AN TIANGUANGYUAN BIOTECH CO., LTD.
18802962783
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+8613111626072 (WhatsApp)
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Capot Chemical Co.,Ltd.
+86(0)13336195806 +86-571-85586718
+86-571-85864795 sales@capotchem.com China 20010 60
Henan DaKen Chemical CO.,LTD.
+86-371-66670886
info@dakenchem.com China 21022 58

303-98-0(補酵素Q10)キーワード:


  • 303-98-0
  • coenzyme Q10 synthetic
  • Coenzyme Q10 (Water soluble)
  • CoQ10 Ubidecarenone
  • Coenzyme Q10 standard
  • COENZYM Q10 SYNTHETIC: 99.5%
  • CoenzymeA/Q0/Q10A85-61-0/Q10
  • CoenzymeQ10Ubidecarenone
  • CoenzymeQ10Usp27Ep5
  • CoenzymeQ10&Int.
  • Coenzyme Q10 (Fermentation)
  • Coenzyme Q10 (Synthesize)
  • Water soluble Coenzyme Q10 (Fermentation)10%/20%
  • Ubidecarenone=Ubiquinone50
  • Ubiquinone 10 (Coenzyme Q10)
  • Ubichinon-50
  • Vitamin-Q10
  • 2,5-Cyclohexadiene-1,4-dione, 2-(2E,6E,10E,14E,18E,22E,26E,30E,34E)-3,7,11,15,19,23,27,31,35,39-decamethyl-2,6,10,14,18,22,26,30,34,38-tetracontadecaenyl-5,6-dimethoxy-3-methyl-
  • UBIDECARENONE,NF
  • RAW MATERIAL COENZYME Q10 POWDER(COQ10)
  • COENZYME Q10(Natural)(P)
  • COENZYMEQ10(UBIQUINONE-10)
  • Ubidecarenone (Coenzyme Q10)
  • Water soluble Coenzyme Q10
  • COENZYME Q1O extrapure
  • NSC 140865
  • PureSorb Q 40
  • Q-Gel
  • Q-Gel 100
  • Unispheres Q 10
  • (all-E)-2-(3,7,11,15,19,23,27,31,35,39-DecaMethyl-2,6,10,14,18,22,26,30,34,38-tetracontadecaenyl)-5,6-(diMethoxy-d6)-3-Methyl-2,5-cyclohexadiene-1,4-dione
  • 補酵素Q10
  • コエンザイムQ10
  • トリデミン
  • ソラネキノン
  • ラコビール
  • 2-[(2E,6E,10E,14E,18E,22E,26E,30E,34E)-3,7,11,15,19,23,27,31,35,39-デカメチル-2,6,10,14,18,22,26,30,34,38-テトラコンタデカエニル]-5,6-ジメトキシ-3-メチル-2,5-シクロヘキサジエン-1,4-ジオン
  • アデリール
  • サンキノン
  • 2-[(2E,6E,10E,14E,18E,22E,26E,30E,34E)-3,7,11,15,19,23,27,31,35,39-デカメチル-2,6,10,14,18,22,26,30,34,38-テトラコンタンデカエニル]-5,6-ジメトキシ-3-メチル-2,5-シクロヘキサジエン-1,4-ジオン
  • 5,6-ジメトキシ-3-メチル-2-[(2E,6E,10E,14E,18E,22E,26E,30E,34E)-3,7,11,15,19,23,27,31,35,39-デカメチル-2,6,10,14,18,22,26,30,34,38-テトラコンタデカエニル]-2,5-シクロヘキサジエン-1,4-ジオン
  • ユベ·Q
  • ヨウビキノン
  • ユビキノンQ10
  • 2,3-ジメトキシ-5-[(2E,6E,10E,14E,18E,22E,26E,30E,34E)-3,7,11,15,19,23,27,31,35,39-デカメチルテトラコンタン-2,6,10,14,18,22,26,30,34,38-デカエン-1-イル]-6-メチル-1,4-ベンゾキノン
  • デカソフト
  • ウビキノン50
  • ユビキノン
  • ユベキノン
  • 2-[(2E,6E,10E,14E,18E,22E,26E,30E,34E)-3,7,11,15,19,23,27,31,35,39-デカメチル-2,6,10,14,18,22,26,30,34,38-テトラコンタデカエニル]-5,6-ジメトキシ-3-メチル-p-ベンゾキノン
  • イノキテン
  • デカレノン
  • コロキノン
  • ノイキノン
  • ユビデカレノン
  • 2,3-ジメトキシ-5-メチル-6-[(2E,6E,10E,14E,18E,22E,26E,30E,34E)-3,7,11,15,19,23,27,31,35,39-デカメチル-2,6,10,14,18,22,26,30,34,38-テトラコンタデカエニル]-p-ベンゾキノン
  • デカントイン
  • カイトロン
  • ユビキノン10
  • ユビキノン-10
  • カルビキノン
  • ユビキノン50
  • ユビキノン-50
  • 補酵素Q10(NATURAL)
  • ユビキノン-10標準品
  • ユビデカレノン (JP17)
  • 構造分類
  • 抗酸化剤
  • 生化学
  • ビタミン
  • ビタミン関連物質
  • ベンゾキノン
  • アルドステロン拮抗薬
  • 強心薬
  • ユビキノール
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