2'-デオキシ-5-(ヒドロキシメチル)シチジン
2'-デオキシ-5-(ヒドロキシメチル)シチジン 物理性質
- 融点 :
- 205°C(lit.)
- 沸点 :
- 575.0±60.0 °C(Predicted)
- 比重(密度) :
- 1.480 g/cm3
- 貯蔵温度 :
- Store at -20°C
- 溶解性:
- DMF: 5 mg/ml; DMSO: 20 mg/ml; PBS (pH 7.2): 10 mg/ml
- 外見 :
- powder to crystal
- 酸解離定数(Pka):
- 13.47±0.10(Predicted)
- 色:
- White to Light yellow
- 極大吸収波長 (λmax):
- 274nm(H2O)(lit.)
- InChI:
- InChI=1S/C10H15N3O5/c11-9-5(3-14)2-13(10(17)12-9)8-1-6(16)7(4-15)18-8/h2,6-8,14-16H,1,3-4H2,(H2,11,12,17)/t6-,7+,8+/m0/s1
- InChIKey:
- HMUOMFLFUUHUPE-XLPZGREQSA-N
- SMILES:
- OC[C@H]1O[C@@H](N2C=C(CO)C(N)=NC2=O)C[C@@H]1O
- CAS データベース:
- 7226-77-9
安全性情報
- リスクと安全性に関する声明
- 危険有害性情報のコード(GHS)
| 絵表示（GHS） |
|
| 注意喚起語 |
|
| 危険有害性情報 |
| コード |
危険有害性情報 |
危険有害性クラス |
区分 |
注意喚起語 |
シンボル |
P コード |
| H302 |
飲み込むと有害 |
急性毒性、経口 |
4 |
警告 |
|
P264, P270, P301+P312, P330, P501 |
|
| 注意書き |
| P264 |
取扱い後は皮膚をよく洗うこと。 |
| P264 |
取扱い後は手や顔をよく洗うこと。 |
| P270 |
この製品を使用する時に、飲食または喫煙をしないこ と。 |
| P301+P312 |
飲み込んだ場合：気分が悪い時は医師に連絡する こと。 |
| P330 |
口をすすぐこと。 |
| P501 |
内容物/容器を．．．に廃棄すること。 |
|
2'-デオキシ-5-(ヒドロキシメチル)シチジン 価格
もっと(4)
| メーカー |
製品番号 |
製品説明 |
CAS番号 |
包装 |
価格 |
更新時間 |
購入 |
|
富士フイルム和光純薬株式会社(wako)
|
W01TRCH946630 |
5-(Hydroxymethyl)-2'-deoxycytidine |
7226-77-9 |
10mg |
￥67200 |
2024-03-01 |
購入 |
|
富士フイルム和光純薬株式会社(wako)
|
W01TRCH946630 |
5-(Hydroxymethyl)-2'-deoxycytidine |
7226-77-9 |
100mg |
￥452700 |
2023-06-01 |
購入 |
|
東京化成工業
|
D4220 |
2'-デオキシ-5-(ヒドロキシメチル)シチジン >98.0%(T)
2'-Deoxy-5-(hydroxymethyl)cytidine
>98.0%(T) |
7226-77-9 |
50mg |
￥16900 |
2024-03-01 |
購入 |
|
東京化成工業
|
D4220 |
2'-デオキシ-5-(ヒドロキシメチル)シチジン >98.0%(T)
2'-Deoxy-5-(hydroxymethyl)cytidine
>98.0%(T) |
7226-77-9 |
200mg |
￥55700 |
2024-03-01 |
購入 |
2'-デオキシ-5-(ヒドロキシメチル)シチジン 化学特性,用途語,生産方法
説明
DNA methylation occurs mainly at the 5’-position of cytosine rings (5-methylcytosine) and occurs almost exclusively in CpG islands. Another epigenetic modification in DNA has been recently identified that involves hydroxymethylation of this same base (5-hydroxymethylcytosine), which potentially offers another level of transcriptional control. 5-(Hydroxymethyl)-2’-deoxycytidine is a modified pyrimidine that is capable of producing interstrand cross-links in double-stranded DNA and has been used to quantify DNA hydroxymethylation levels in biological samples.
生物学の機能
5-(hydroxymethyl)-2'-deoxycytidine (5-hmdC), the oxidative product from 5- (methyl)-2'-deoxycytidine (5-mdC) by TET protein, plays critical roles in a variety of physiological processes such as DNA demethylation, cellular differentiation, and epigenetic regulation, etc. In addition, 5-hmdC has also been demonstrated as a potential biomarker reflecting the diagnosis and prognosis of multiple diseases. Some studies have reported that the level of 5-hmdC significantly decreases in diversified cancers, which suggests its important role in tumor formation and development. In 2009, breakthrough studies found that the 5-hmdC is not the unique oxidative product of 5-mdC. 5-(hydroxymethyl)-2'-deoxycytidine is a crucial intermediate product of the DNA demethylation pathway, which can act as potential biomarkers reflecting the diagnosis and prognosis in multiple tumors. 5-hmdC in human urine is in the form of single deoxynucleosides produced by DNA degradation or metabolism, which can avoid digestion. 5-hmdC has been identified in human urine[1].
2'-デオキシ-5-(ヒドロキシメチル)シチジン 上流と下流の製品情報
原材料
準備製品
2'-デオキシ-5-(ヒドロキシメチル)シチジン 生産企業
Global( 72)Suppliers
7226-77-9(2'-デオキシ-5-(ヒドロキシメチル)シチジン)キーワード:
- 7226-77-9
- 5-hydroxymethyldeoxycytidine monophosphate
- 2'-deoxy-5-(hydroxyMethyl)cytidine
- 4-(HydroxyMethyl)-2'-deoxycytidine
- Cytidine, 2'-deoxy-5-(hydroxyMethyl)-
- 5-Hydroxymethyl-dC
- 5-hmdC
- 2'-Deoxy-5-(hydroxymethyl)cytidine>
- 5-hydroxy methyl-2'-dC
- 4-Amino-1-((2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-(hydroxymethyl)pyrimidin-2(1H)-one
- 5-Hydroxymethyl-2'-deoxycytidine
- 2'-デオキシ-5-(ヒドロキシメチル)シチジン