ロシグリタゾンマレイン酸塩
ロシグリタゾンマレイン酸塩 物理性質
- 融点 :
- 235-240°C
- 貯蔵温度 :
- 2-8°C
- 溶解性:
- DMSO に可溶 (最大 50 mg/ml)。
- 酸解離定数(Pka):
- 6.1; 6.8(at 25℃)
- 外見 :
- 白い粉
- 色:
- 白い
- BCS Class:
- 1
- 安定性：:
- 購入日から2年間安定です。この DMSO 溶液は、-20°C で 3 か月間保存できます。
- InChIKey:
- HCDYSWMAMRPMST-NTCAYCPXSA-N
- CAS データベース:
- 155141-29-0(CAS DataBase Reference)
ロシグリタゾンマレイン酸塩 価格
もっと(18)
| メーカー |
製品番号 |
製品説明 |
CAS番号 |
包装 |
価格 |
更新時間 |
購入 |
|
富士フイルム和光純薬株式会社(wako)
|
W01COBQA-7955 |
マレイン酸ロシグリタゾン
Rosiglitazone maleate |
155141-29-0 |
1g |
￥10000 |
2024-03-01 |
購入 |
|
富士フイルム和光純薬株式会社(wako)
|
W01COBQA-7955 |
マレイン酸ロシグリタゾン
Rosiglitazone maleate |
155141-29-0 |
5g |
￥35000 |
2024-03-01 |
購入 |
|
富士フイルム和光純薬株式会社(wako)
|
W01COBQA-7955 |
Rosiglitazone maleate |
155141-29-0 |
25g |
￥120000 |
2024-03-01 |
購入 |
|
富士フイルム和光純薬株式会社(wako)
|
W01COBQA-7955 |
Rosiglitazone maleate |
155141-29-0 |
100g |
￥420000 |
2024-03-01 |
購入 |
|
Sigma-Aldrich Japan
|
1605817 |
United States Pharmacopeia (USP) Reference Standard
Rosiglitazone maleate United States Pharmacopeia (USP) Reference Standard |
155141-29-0 |
200mg |
￥55400 |
2024-03-01 |
購入 |
ロシグリタゾンマレイン酸塩 化学特性,用途語,生産方法
溶解性
アセトン、エタノール及び水に溶ける。
用途
チアゾリジン系のPPARγ 作
用剤で、インスリン抵抗性を改善し、血糖低
下作用を示します。
効能
糖尿病治療薬, ペルオキシソーム増殖因子活性化受容体(PPAR)γ作動薬
説明
Rosiglitazone maleate, belongs to a novel class of thiazolidine diones
launched for the treatment of non-insulin-dependent diabetes mellitus (NIDDM),
a disease characterized by a pancreatic β-cell defect and insulin resistance in
the liver and peripheral tissues. The racemic base can be obtained by
KnSvenagel condensation between 2, 4-thiazolidinedione and the corresponding
4-substituted benzaldehyde (itself prepared in 2 steps from 2-chloropyridine),
followed by reduction of the benzylidene. Rosiglitazone was shown to be a
potent agonist of peroxisome proliferator activated receptor-gamma (PPARgamma),
a nuclear receptor involved in the differentiation of adipose tissue,
without activating liver PPAR-alpha receptors. This activation of PPAR-gamma
could mediate the down-regulation of leptin gene expression. In animal models,
Rosiglitazone has been shown to normalize glucose metabolism and reduce the
exogenous dose of insulin needed to achieve glycemic control. In patients with
Type II diabetes, daily doses (4 or 8 mg) of Rosiglitazone significantly improved
blood sugar control without affecting cardiac structure or function.
化学的特性
White To Off-White Solid
使用
Insulin sensitizer; binds to peroxisome proliferator activated receptor gamma (PPAR- γ).
適応症
Rosiglitazone maleate is an antihyperglycemic agent in the thiazolidinedione class. It is indicated for the treatment of patients with type 2 diabetes mellitus.
一般的な説明
A thiazolidinedione compound that acts as an anti-diabetic agent and serves as a potent and selective agonist of peroxisome proliferator-activated receptor-g (PPARg) (K
d ~40 nM) in fat cells. Shown to reduce fatty acid uptake and ameliorate lipid metabolism and insulin resistance in animal models of type II diabetes. Reported to activate both a1- and a2-containing AMPK complexes. Unlike troglitazone, it does not induce the activity of P4503A4. Significantly improves the differentiation of C3H10T1/2 stem cells into adipocytes. Shown to block estrogen synthesis by interfering with androgen binding to aromatase, but without affecting aromatase mRNA or protein expression.
ロシグリタゾンマレイン酸塩 上流と下流の製品情報
原材料
準備製品
ロシグリタゾンマレイン酸塩 生産企業
Global( 365)Suppliers
ロシグリタゾンマレイン酸塩 スペクトルデータ(1HNMR)
155141-29-0(ロシグリタゾンマレイン酸塩)キーワード:
- 155141-29-0
- 5-((4-[2-(METHYL-2-PYRIDINYLAMINO)-ETHOXY]-PHENYL)-METHYLENE)-2,4-THIAZOLIDINEDIONE
- 5-{p-[2-(methyl-2-pyridylamino)ethoxy]benzyl}-2,4-thiazolidinedione maleate
- ROSIGLITAZONE MALEATE
- RosiglitazoneTartrate
- Avandi
- BRL-49653c
- RSIGLITAZONEMALEATE
- 5-(4-(2-(Methyl(pyridin-2-yl)aMino)ethoxy)benzyl)thiazolidine-2,4-dione Maleate
- Rosiglitazone Maleate (200 mg)
- 5-[[4-[2-(Methyl-2-pyridinylaMino)ethoxy]phenyl]Methyl]-2,4-thiazolidinedione (2Z)-2-Butenedioate
- Rosiglitazone Maleate forM
- Rosiglitazone-d3 Maleate
- 5-[[4-[2-(methyl-2-pyridinylamino)ethoxy]phenyl]methyl]-2,4-thiazolidinedione,(2Z)-2-butenedioate (1:1)
- 5-[[4-[2-(Methyl-2-pyridinylamino)ethoxy]phenyl]methyl]-2,4-thiazolidinedione maleate salt
- 5-[[4-[2-[methyl(2-pyridinyl)amino]ethoxy]phenyl]methyl]thiazolidine-2,4-dione
- Rosiglitazone maleate Solution, 1000ppm
- 2,4-Thiazolidinedione, 5-[[4-[2-(methyl-2-pyridinylamino)ethoxy]phenyl]methyl]-, (2Z)-2-butenedioate (1:1)
- Rosiglitazone maleate USP/EP/BP
- Rosiglitazone maleateQ: What is
Rosiglitazone maleate Q: What is the CAS Number of
Rosiglitazone maleate Q: What is the storage condition of
Rosiglitazone maleate Q: What are the applications of
Rosiglitazone maleate
- 2,4-Thiazolidinedione, 5-[[4-[2-(methyl-2-pyridinylamino)ethoxy]phenyl]methyl]-, (2Z)-2-butenedioate (1:1) (9CI, ACI)
- 5-[[4-[2-(methyl-2-pyridinylamino)ethoxy]phenyl]methyl]-2,4-Thiazolidinedione (2Z)-2-butenedioate (1:1) (9CI ACI)
- β-D-Fructopyranose1-Sulfamate
- Rosiglitazone (BRL-49653) maleate
- ロシグリタゾンマレイン酸塩
- マレイン酸ロシグリタゾン
- ロシグリタゾンマレイン酸塩 (JAN)