(3aS)-3a,4,5,6,6a,7,9aβ,9bα-オクタヒドロ-6,9-ジメチル-3-メチレン-6α,6aα-エポキシアズレノ[4,5-b]フラン-2(3H)-オン

(3aS)-3a,4,5,6,6a,7,9aβ,9bα-オクタヒドロ-6,9-ジメチル-3-メチレン-6α,6aα-エポキシアズレノ[4,5-b]フラン-2(3H)-オン 価格

メーカー	製品番号	製品説明	CAS番号	包装	価格	更新時間	購入

(3aS)-3a,4,5,6,6a,7,9aβ,9bα-オクタヒドロ-6,9-ジメチル-3-メチレン-6α,6aα-エポキシアズレノ[4,5-b]フラン-2(3H)-オン 化学特性,用途語,生産方法

説明

Arglabin is a new antineoplastic agent launched in Russia for the treatment of a variety of cancers. It is a sesquiterpene gamma-lactone extracted from Artemisia glabella, a plant from Kazakstan; it was first developed in Kazakstan followed by US and other countries as an ethical pharmaceutical. Arglabin can be obtained by resin extraction from A.glabella, purification by chromatography and finally recrystallization. Arglabin is a potent and selective inhibitor of farnesyl transferase, an enzyme critical to the function of the Ras oncogene in cancer cell reproduction. It showed a strong Inhibitory effect against tumor cells proliferation in in vitro models of transformed mouse hepatocytes and splenocytes. This cytotoxic effect against tumor cells was 50-100 times higher than that on intact cells. In many patients with various cancers, Arglabin was shown to stop or inhibit the tumour development, alone or in combination with other anticancer agents, and was reportedly well tolerated with few sideeffects. Promising response rates were also reported with Arglabin after treating other 《difficult-to-treat cancers》 such as breast, ovarian, lung or colon cancers.

Originator

NuOncology Labs (Kazakstan)

定義

ChEBI: An organic heterotetracyclic compound and guaianolide sesquiterpene lactone that is acrylic acid which is substituted at position 2 by a 4-hydroxy-3,8-dimethyl-1,3a,4,5,6,7-hexahydroazulen-5-yl group in which the double bond in the 7-membered ring has been epoxidised and in which the hydroxy group and the carboxy group have undergone formal condensation to give the corresponding gamma-lactone. It is found in Artemisia glabella. Arglabin-DMA HCl, the hydrochloride salt of the add ct resulting from the conjugate addition of dimethylamine to the ene-lactone moiety, has been successfully used in Khazakhstan for the treatment of breast, colon, ovarian and lung cancers.

(3aS)-3a,4,5,6,6a,7,9aβ,9bα-オクタヒドロ-6,9-ジメチル-3-メチレン-6α,6aα-エポキシアズレノ[4,5-b]フラン-2(3H)-オン 上流と下流の製品情報

原材料

準備製品

(3aS)-3a,4,5,6,6a,7,9aβ,9bα-オクタヒドロ-6,9-ジメチル-3-メチレン-6α,6aα-エポキシアズレノ[4,5-b]フラン-2(3H)-オン 生産企業

名前	電話番号	電子メール	国籍	製品カタログ	優位度
Shanghai Zheyan Biotech Co., Ltd.	18017610038	zheyansh@163.com	CHINA	3620	58
Chengdu Greenpure Biopharma CO.,Ltd	18283602253	jancyzheng@gcgreenpure.com	China	952	58
career henan chemical co	+86-0371-86658258	sales@coreychem.com	China	29914	58
Chengdu GLP biotechnology Co Ltd	028-87075086 13350802083	scglp@glp-china.com	CHINA	1824	58
Chengdu Biopurify Phytochemicals Ltd.	+8618080483897	sales@biopurify.com	China	3424	58
Shaanxi Pioneer Biotech Co., Ltd .	+8613259417953	sales@pioneerbiotech.com	China	3000	58
NanJing Spring & Autumn Biological Engineering CO., LTD.	+8613815430202	sale02@cqherb.com	CHINA	376	58
Chongqing Chemdad Co., Ltd	+86-023-61398051 +8613650506873	sales@chemdad.com	China	39916	58
Neostar United (Changzhou) Industrial Co., Ltd.	+86-519-519-85557386	marketing1@neostarunited.com	China	8349	58
SIMAGCHEM CORP	+86-13806087780	sale@simagchem.com	China	17367	58

84692-91-1((3aS)-3a,4,5,6,6a,7,9aβ,9bα-オクタヒドロ-6,9-ジメチル-3-メチレン-6α,6aα-エポキシアズレノ[4,5-b]フラン-2(3H)-オン)キーワード:

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• 84692-91-1
• (3aR,4aS,6aS,9aS,9bR)-5,6,6a,7,9a,9b-Hexahydro-1,4a-dimethyl-7-methylene-3H-oxireno[8,8a]azuleno[4,5-b]furan-8(4aH)-one
• arglabin
• (3aR,4aS)-1,4aα-Dimethyl-7-methylene-4a,5,6,6aα,9aβ,9bα-hexahydro-3H-oxireno[8,8a]azuleno[4,5-b]furan-8(7H)-one
• (3aS)-2,3,3aβ,4,5β,6,6a,7,9aβ,9bα-Decahydro-6α,6aα-epoxy-6,9-dimethyl-3-methyleneazuleno[4,5-b]furan-2-one
• 3H-Oxireno[8,8a]azuleno[4,5-b]furan-8(4aH)-one, 5,6,6a,7,9a,9b-hexahydro-1,4a-diMethyl-7-Methylene-, [4aS-(3aS*,4aα,6aα,9aβ,9bα)]-
• Arglabine
• 3H-Oxireno[8,8a]azuleno[4,5-b]furan-8(4aH)-one,5,6,6a,7,9a,9b-hexahydro-1,4a-dimethyl-7-methylene-, (3aR,4aS,6aS,9aS,9bR)
• Arglabin 84692-91-1
• Arglabin, BR
• CS-1320
• Arglabin ((+)-Arglabin)
• (+)-Arglabin
• アルグラビン
• (3aS)-2,3,3aβ,4,5β,6,6a,7,9aβ,9bα-デカヒドロ-6α,6aα-エポキシ-6,9-ジメチル-3-メチレンアズレノ[4,5-b]フラン-2-オン
• (3aR,4aS)-1,4aα-ジメチル-7-メチレン-4a,5,6,6aα,9aβ,9bα-ヘキサヒドロ-3H-オキシレノ[8,8a]アズレノ[4,5-b]フラン-8(7H)-オン
• (3aS)-3a,4,5,6,6a,7,9aβ,9bα-オクタヒドロ-6,9-ジメチル-3-メチレン-6α,6aα-エポキシアズレノ[4,5-b]フラン-2(3H)-オン
• (1R,3S,6S,10S,11R)-3,12-ジメチル-7-メチリデン-2,9-ジオキサテトラシクロ[9.3.0.01,3.06,10]テトラデカ-12-エン-8-オン