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チアミン

チアミン 化学構造式
59-43-8
CAS番号.
59-43-8
化学名:
チアミン
别名:
ベチアミン;アノイリン;チアミニウムクロリド;アニューリン;ビタミンB1;チアミン;ベイボン;チアコート;ベタビオン;3-[(4-アミノ-2-メチルピリミジン-5-イル)メチル]-5-(2-ヒドロキシエチル)-4-メチルチアゾール-3-イウム·クロリド;オリザニン;ビタノイリン;アパタートドレープ;ビタミン B1
英語化学名:
Thiamine chloride
英語别名:
b-amin;beivon;Betamin;Biamine;weissb1;thiamin;Beta-Sol;Metatone;Thiacoat;aneurine
CBNumber:
CB0154385
化学式:
C12H17ClN4OS
分子量:
300.81
MOL File:
59-43-8.mol

チアミン 物理性質

融点 :
248 °C (decomp)
比重(密度) :
1.3175 (rough estimate)
屈折率 :
1.5630 (estimate)
貯蔵温度 :
Keep in dark place,Inert atmosphere,Room temperature
CAS データベース:
59-43-8(CAS DataBase Reference)
EPAの化学物質情報:
Thiamine (59-43-8)

安全性情報

有毒物質データの 59-43-8(Hazardous Substances Data)

チアミン 価格

メーカー 製品番号 製品説明 CAS番号 包装 価格 更新時間 購入

チアミン MSDS


Thiamine chloride

チアミン 化学特性,用途語,生産方法

定義

本品は、ビタミンB2であり、次の化学式で表される。

化粧品の成分用途

皮膚コンディショニング剤

効能

ビタミンB1補充薬

Originator

Thiamine chloride,Sopharma

Manufacturing Process

2 Methods of preparation of thiamine:
1. 3-Ethoxypropionitrile reacted with diethoxymethoxy-ethane and 3-ethoxy- 2-methoxymethylenpropionitrile was obtained.
Then to the 3-ethoxy-2-methoxymethylenpropionitrile acetamidine was added and reaction mixture was stirred to give 4-amino-5-ethoxy-methyl-2- methylpyrimidine.
The 4-amino-5-ethoxy-methyl-2-methylpyrimidine was treated by hydrobromic acid to afford 4-amino-5-bromomethyl-2-methylpyrimidine hydrobromide.
The 4-amino-5-bromomethyl-2-methylpyrimidine hydrobromide reacted with 5-(2-hydroxyethyl)-4-methylthiazole in the presence of hydrobromic acid and as the result thiaminbromide was produced. For changing of the thiaminbromide to the thiamincloride the thiaminbromide was treated by AgCl.
2. To diethoxymethoxy-ethane malononitrile was added and ethoxymethylenmalononitrile was obtained. The ethoxymethylen-malononitrile reacted with acetamidine as a result 4-amino-5-cyano-2-methylpyrimidine was produced, which was reduced by H2/Raney-Ni to 4-amino-5-aminomethyl-2- methylpyrimidine.
To the 4-amino-5-aminomethyl-2-methylpyrimidine 1-acetoxy-3-chloropentan- 4-one was added in the presence CS2 and NH3, and reaction mixture was stirred, then to this mixture hydrochloric acid was added and thiamin (base) was obtained.
To thiamin (base) H2O2 and hydrocloricum acid are added, in the result reaction the thiamine chloride was obtained.

Therapeutic Function

Enzyme cofactor vitamin, Antineuritic

一般的な説明

Thiamine, the preferred name for vitamin B1, holds a prominent place in the history of vitamin discovery because beriberi, the disease resulting from insufficient thiamine intake, was one of the earliest recognized deficiency diseases.

生物活性

Some earlier designations for this substance included aneurin, antineuritic factor, antiberiberi factor, and oryzamin. Thiamine is metabolically active as thiamine pyrophosphate (TPP).
TPP functions as a coenzyme which participates in decarboxylation of α-keto acids. Dehydrogenation and decarboxylation must precede the formation of “active acetate” in the initial reaction of the TCA cycle (citric acid cycle):图
This reaction is a good example of the interrelationship of vitamin B coenzymes. Four vitamin coenzymes are necessary for this one reaction: (1) thiamine (in TPP) for decarboxylation; (2) nicotinic acid in nicotinamide adenine dinucleotide (NAD); (3) riboflavin in flavin adenine dinucleotide (FAD); and (4) pantothenic acid in coenzyme A (CoA) for activation of the acetate fragment.

臨床応用

Thiamine chloride, as the base or as the hydrochloride salt, is indicatedin the treatment or prophylaxis of known or suspected thiaminedeficiencies. Severe thiamine deficiency is calledberiberi, which is very rare in developed countries. The mostlikely cause of thiamine deficiency in the United States is theresult of chronic alcoholism, which leads to multiple vitamindeficiencies as a result of poor dietary intake. The major organsaffected are the nervous system (dry beriberi), whichmanifests as neurological damage, the cardiovascular system(wet beriberi), which manifests as heart failure and edema, andthe gastrointestinal tract. Thiamine administration reverses thegastrointestinal, cardiovascular, and neurological symptoms;however, if the deficiency has been severe or of prolonged duration, the neurological damage may be permanent.

安全性プロファイル

Poison by subcutaneous and intravenous routes. An experimental teratogen. Experimental reproductive effects. When heated to decomposition it emits very toxic fumes of NOx, SOx, and Cl-.

チアミン 上流と下流の製品情報

原材料

準備製品


チアミン 生産企業

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59-43-8(チアミン)キーワード:


  • 59-43-8
  • THIAMIMEMONOCHLORIDE
  • VITAMIN B1(THIAMINE)(BASF)(SH)
  • VITAMIN B1(THIAMINE)(SH)
  • Antiberiberi factor
  • Betamin
  • Beta-Sol
  • Biamine
  • Metatone
  • Vitamin B1
  • Thiazolium, 3-(4-amino-2-methyl-5-pyrimidinyl)methyl-5-(2-hydroxyethyl)-4-methyl- chloride
  • 2-[3-[(4-amino-2-methyl-pyrimidin-5-yl)methyl]-4-methyl-1-thia-3-azoniacyclopenta-2,4-dien-5-yl]ethanol
  • thiamine(1+) chloride
  • Thiamine VB
  • weissb1
  • THIAMINB-1
  • Thiamine (unspecified salts)
  • 3-((4-Amino-2-methyl-5-pyrimidinyl)methyl)-5-(2- hydroxyethyl)-4-methylthiazolium chloride
  • Thiamine chloride
  • Vitamin B1
  • VITAMIN B1(MONO HCL: USP) (THIAMINE HCL)
  • Vitamin B1 Mononitrate (Mono)
  • Thiacoat
  • Vitaneurin
  • Vb1 VitaMin
  • 3-((4-aMino-2-MethylpyriMidin-5-yl)Methyl)-5-(2-hydroxyethyl)-4-Methylthiazol-3-iuM chloride
  • 3-((4-amino-2-methyl-5-pyrimidinyl)methyl)-5-(2-hydroxyethyl)-4-methylthiazoli
  • aneurine
  • apatatedrape
  • b-amin
  • beivon
  • ベチアミン
  • アノイリン
  • チアミニウムクロリド
  • アニューリン
  • ビタミンB1
  • チアミン
  • ベイボン
  • チアコート
  • ベタビオン
  • 3-[(4-アミノ-2-メチルピリミジン-5-イル)メチル]-5-(2-ヒドロキシエチル)-4-メチルチアゾール-3-イウム·クロリド
  • オリザニン
  • ビタノイリン
  • アパタートドレープ
  • ビタミン B1
  • ビタミンB群
  • 代謝作用薬
  • リボフラビン
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