ChemicalBook
Chinese english Germany Korea

4-ヒドロキシ安息香酸プロピル

4-ヒドロキシ安息香酸プロピル 化学構造式
94-13-3
CAS番号.
94-13-3
化学名:
4-ヒドロキシ安息香酸プロピル
别名:
4-ヒドロキシ安息香酸プロピル;プロピルブテックス;プルビスコンサーバンス;パセプトール;プロピルp-ヒドロキシベンゾアート;アセプトホルムP;テゴセプトP;プロピルケモセプト;プレセルバールP;4-ヒドロキシベンゼンカルボン酸プロピル;ニパソールM;プロピルアセプトホルム;プロピルパラベン;ソルブロールP;プロピルパラセプト;パラオキシ安息香酸プロピル;ニパギンP;ニパソールP;ニパソール;ニパゾール
英語化学名:
Propylparaben
英語别名:
Nipasol;Nipazol;nipaginp;NipasolM;nipasolp;Parabens;Paseptol;Propagin;solbrolp;betacinep
CBNumber:
CB0176673
化学式:
C10H12O3
分子量:
180.2
MOL File:
94-13-3.mol

4-ヒドロキシ安息香酸プロピル 物理性質

融点 :
95-98 °C(lit.)
沸点 :
133°C
比重(密度) :
1.0630
蒸気圧:
0.67 hPa (122 °C)
FEMA :
2951 | PROPYL P-HYDROXYBENZOATE
屈折率 :
1.5050
闪点 :
180°(356°F)
貯蔵温度 :
0-6°C
溶解性:
ethanol: soluble0.1M, clear, colorless
外見 :
Crystalline Powder
酸解離定数(Pka):
pKa 8.4 (Uncertain)
色:
White
比重:
0.789 (20/4℃)
PH:
6-7 (H2O, 20°C) (saturated solution)
水溶解度 :
<0.1 g/100 mL at 12 ºC
Merck :
14,7866
BRN :
1103245
安定性::
Stable. Incompatible with strong oxidizing agents, strong bases.
InChIKey:
QELSKZZBTMNZEB-UHFFFAOYSA-N
CAS データベース:
94-13-3(CAS DataBase Reference)
NISTの化学物質情報:
N-propyl-p-hydroxy-benzoate(94-13-3)
EPAの化学物質情報:
Benzoic acid, 4-hydroxy-, propyl ester(94-13-3)

安全性情報

主な危険性  Xi
Rフレーズ  36/37/38
Sフレーズ  26-24/25-36
WGK Germany  1
RTECS 番号 DH2800000
自然発火温度 >600 °C
TSCA  Yes
HSコード  29182930
有毒物質データの 94-13-3(Hazardous Substances Data)
毒性 LD50 orally in Rabbit: > 5000 mg/kg
化審法 (3)-1585

4-ヒドロキシ安息香酸プロピル 価格 もっと(44)

メーカー 製品番号 製品説明 CAS番号 包装 価格 更新時間 購入
富士フイルム和光純薬株式会社(wako) W01ACSALR-153N プロピルパラベン
Propyl paraben
94-13-3 100mg ¥3700 2018-12-26 購入
富士フイルム和光純薬株式会社(wako) W01ACSALR-153S プロピルパラベン
Propyl paraben, 100 ug/mL in MeOH
94-13-3 1mL ¥3700 2018-12-26 購入
東京化成工業 H0219 4-ヒドロキシ安息香酸プロピル >99.0%(T)
Propyl 4-Hydroxybenzoate >99.0%(T)
94-13-3 25g ¥1700 2018-12-04 購入
東京化成工業 H0219 4-ヒドロキシ安息香酸プロピル >99.0%(T)
Propyl 4-Hydroxybenzoate >99.0%(T)
94-13-3 500g ¥6000 2018-12-04 購入
関東化学株式会社(KANTO) 13159-2A p‐ヒドロキシ安息香酸n‐プロピル >99.0%
n‐Propyl p‐hydroxybenzoate >99.0%
94-13-3 500g ¥10700 2018-12-13 購入

4-ヒドロキシ安息香酸プロピル MSDS


4-Hydroxybenzoic acid propyl ester

4-ヒドロキシ安息香酸プロピル 化学特性,用途語,生産方法

外観

無色の結晶又は白色の結晶性粉末

定義

本品は、パラヒドロキシ安息香酸とプロパノール(*)のエステルであり、次の化学式で表される。
参照表示名称:プロパノール

溶解性

水に難溶。エタノール, エーテルに可溶。

用途

保存料。

化粧品の成分用途

防腐剤、香料

効能

防腐剤

化学的特性

White or almost white, crystalline powder.

化学的特性

Propylparaben occurs as a white, crystalline, odorless, and tasteless powder.

化学的特性

Propyl p-hydroxybenzoate is almost odorless.

使用

propylparaben is one of the most frequently used preservatives against bacteria and mold. It has a low sensitizing and low toxicity factor, is reputed to be very safe, and considered to be a noncomedogenic raw material.

使用

An antimicrobial

使用

Pharmaceutic aid (antifungal). Antimicrobial preservative in foods and cosmetics.

定義

ChEBI: The benzoate ester that is the propyl ester of 4-hydroxybenzoic acid. Preservative typically found in many water-based cosmetics, such as creams, lotions, shampoos and bath products. Also used as a food additive.

調製方法

Propylparaben is prepared by the esterification of p-hydroxybenzoic acid with n-propanol.

製造方法

Produced by esterfying p-hydroxybenzoic acid with n-propanol, using an acid catalyst such as sulfuric acid and an excess of propanol. The materials are heated in a glass-lined reactor under reflux. The acid is then neutralized with caustic soda and the product is crystallized by cooling. The crystallized product is centrifuged, washed, dried under vacuum, milled and blended, all in corrosion-resistant equipment to avoid metallic contamination.

Aroma threshold values

Detection: 20 ppb

一般的な説明

Colorless crystals or white powder or chunky white solid. Melting point 95-98°C. Odorless or faint aromatic odor. Low toxicity, Tasteless (numbs the tongue). pH: 6.5-7.0 (slightly acidic) in solution.

空気と水の反応

Water soluble [Hawley].

反応プロフィール

Maximum stability of Propylparaben occurs at a pH of 4 to 5. Incompatible with alkalis and iron salts. Also incompatible with strong oxidizing agents and strong acids .

火災危険

Flash point data for Propylparaben are not available; however, Propylparaben is probably combustible.

応用例(製薬)

Propylparaben is widely used as an antimicrobial preservative in cosmetics, food products, and pharmaceutical formulations.
It may be used alone, in combination with other paraben esters, or with other antimicrobial agents. It is one of the most frequently used preservatives in cosmetics.
The parabens are effective over a wide pH range and have a broad spectrum of antimicrobial activity, although they are most effective against yeasts and molds.
Owing to the poor solubility of the parabens, the paraben salts, particularly the sodium salt, are frequently used in formulations. This may cause the pH of poorly buffered formulations to become more alkaline.
Propylparaben (0.02% w/v) together with methylparaben (0.18% w/v) has been used for the preservation of various parenteral pharmaceutical formulations.

接触アレルゲン

This substance is one of the parabens family. Parabens are esters formed by p-hydroxybenzoic acid and an alcohol. They are largely used as biocides in cosmetics and toiletries, medicaments, or food. They have synergistic power with other biocides. Parabens can induce allergic contact dermatitis, mainly in chronic dermatitis and wounded skin.

安全性

Propylparaben and other parabens are widely used as antimicrobial preservatives in cosmetics, food products, and oral and topical pharmaceutical formulations.
Propylparaben and methylparaben have been used as preservatives in injections and ophthalmic preparations; however, they are now generally regarded as being unsuitable for these types of formulations owing to the irritant potential of the parabens. Systemically, no adverse reactions to parabens have been reported, although they have been associated with hypersensitivity reactions. The WHO has set an estimated acceptable total daily intake for methyl, ethyl, and propyl parabens at up to 10 mg/kg body-weight.
LD50 (mouse, IP): 0.2 g/kg
LD50 (mouse, oral): 6.33 g/kg
LD50 (mouse, SC): 1.65 g/kg

貯蔵

Aqueous propylparaben solutions at pH 3–6 can be sterilized by autoclaving, without decomposition.At pH 3–6, aqueous solutions are stable (less than 10% decomposition) for up to about 4 years at room temperature, while solutions at pH 8 or above are subject to rapid hydrolysis (10% or more after about 60 days at room temperature).

不和合性

The antimicrobial activity of propylparaben is reduced considerably in the presence of nonionic surfactants as a result of micellization. Absorption of propylparaben by plastics has been reported, with the amount absorbed dependent upon the type of plastic and the vehicle. Magnesium aluminum silicate, magnesium trisilicate, yellow iron oxide, and ultramarine blue have also been reported to absorb propylparaben, thereby reducing preservative efficacy.
Propylparaben is discolored in the presence of iron and is subject to hydrolysis by weak alkalis and strong acids.

規制状況(Regulatory Status)

Propylparaben and methylparaben are affirmed GRAS direct food substances in the USA at levels up to 0.1%. All esters except the benzyl ester are allowed for injection in Japan. In cosmetics, the EU and Brazil allow use of each paraben at 0.4%, but the total of all parabens may not exceed 0.8%. The upper limit in Japan is 1.0%.
Accepted as a food additive in Europe. Included in the FDA Inactive Ingredients Database (IM, IV, and SC injections; inhalations; ophthalmic preparations; oral capsules, solutions, suspensions, and tablets; otic, rectal, topical, and vaginal preparations).
Included in parenteral and nonparenteral medicines licensed in the UK. Included in the Canadian List of Acceptable Non-medicinal Ingredients.

4-ヒドロキシ安息香酸プロピル 上流と下流の製品情報

原材料

準備製品


4-ヒドロキシ安息香酸プロピル 生産企業

Global( 353)Suppliers
名前 電話番号 ファックス番号 電子メール 国籍 製品カタログ 優位度
Hefei TNJ Chemical Industry Co.,Ltd.
86-0551-65418684 18949823763
86-0551-65418684 info@tnjchem.com China 1849 55
Shenzhen Sendi Biotechnology Co.Ltd.
0755-23311925 18102838259
0755-23311925 Abel@chembj.com CHINA 3194 55
Henan DaKen Chemical CO.,LTD.
+86-371-55531817
info@dakenchem.com CHINA 21752 58
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 20672 55
Mainchem Co., Ltd.
+86-0592-6210733
+86-0592-6210733 sales@mainchem.com CHINA 32447 55
Tianjin Zhongxin Chemtech Co., Ltd.
022-89880739
022-66880086 sales@tjzxchem.com CHINA 575 58
Shanghai Zheyan Biotech Co., Ltd.
18017610038
zheyansh@163.com CHINA 3623 58
career henan chemical co
+86-371-86658258
sales@coreychem.com CHINA 27142 58
Chemwill Asia Co.,Ltd.
86-21-51086038
86-21-51861608 chemwill_asia@126.com;sales@chemwill.com;chemwill@hotmail.com;chemwill@gmail.com CHINA 23967 58
Hubei Jusheng Technology Co.,Ltd.
86-18871470254
027-59599243 sales@jushengtech.com CHINA 28236 58

94-13-3(4-ヒドロキシ安息香酸プロピル)キーワード:


  • 94-13-3
  • Propyl 4-hydroxybenzoate, 99+% 500GR
  • Propyl 4-hydroxybenzoate, 99+% 5GR
  • 4-hydroxy-benzoicacipropylester
  • Aseptoform P
  • aseptoformp
  • Benzoic acid, 4-hydroxy-, propyl ester
  • Benzoic acid, p-hydroxy-, propyl ester
  • Benzoicacid,4-hydroxy-,propylester
  • Betacide P
  • betacidep
  • betacinep
  • Bonomold OP
  • bonomoldop
  • Chemacide pk
  • Chemocide PK
  • chemocidepk
  • Chemoside PK
  • femanumber2951
  • Lexgard P
  • Nipagin P
  • nipaginp
  • Nipasol
  • Nipasol M
  • Nipasol P
  • NipasolM
  • nipasolp
  • Nipazol
  • N-Propylparaben
  • Parabens
  • Paseptol
  • 4-ヒドロキシ安息香酸プロピル
  • プロピルブテックス
  • プルビスコンサーバンス
  • パセプトール
  • プロピルp-ヒドロキシベンゾアート
  • アセプトホルムP
  • テゴセプトP
  • プロピルケモセプト
  • プレセルバールP
  • 4-ヒドロキシベンゼンカルボン酸プロピル
  • ニパソールM
  • プロピルアセプトホルム
  • プロピルパラベン
  • ソルブロールP
  • プロピルパラセプト
  • パラオキシ安息香酸プロピル
  • ニパギンP
  • ニパソールP
  • ニパソール
  • ニパゾール
  • ケモシドPK
  • p-ヒドロキシ安息香酸プロピル
  • ボノモルドOP
  • プロパギン
  • P-ヒドロキシ安息香酸N-プロピル
  • P-ヒドロキシ安息香酸N-プロピル標準品
  • pヒドロキシ安息香酸プロピル
  • p‐ヒドロキシ安息香酸n‐プロピル
  • 4-ヒドロキシ安息香酸プロピル [生化学用]
  • P‐ヒドロキシ安息香酸N‐プロピル標準品
  • プロピルパラベン, 100 µg/mL in MeOH
  • パラオキシ安息香酸プロピル (JP17)
  • 保存料
  • 防腐剤
  • 殺菌薬
Copyright 2017 © ChemicalBook. All rights reserved