Z-LEU-LEU-ノルバリナール 化学特性,用途語,生産方法
外観
白色～ほとんど白色, 結晶～粉末又は塊
溶解性
1.1mlのDMSOをバイアルに入れ、キャップを締めて、粉末が溶解するまで激しく振ります。これで10mMの溶液が調製できます。この溶液は-20℃保存で1ヶ月以上安定です。また、本品1mgを水とアセトニトリルの等量混合溶液5mlに水浴中加温溶解で全溶します。
用途
ユビキチン関連研究用阻害剤。
説明
(S)-
MG115 is a potent and reversible proteasome inhibitor, targeting the chymotryptic site on the 20S particle (K
i = 21 nM). It reduces the degradation of ubiquitin-
conjugated proteins in extracts. (S)-
MG115 also blocks the degradation of long-
and short-
lived proteins in intact cells as well as the proteolytic generation of diverse proteins, including NF-
κB, antigens, and p53. Proteasome inhibitors, including (S)-
MG115, can induce a heat shock response and apoptosis, particularly in cancer cells.
使用
MG-115 is a compound that inhibits the chymotrypsin-like activity of the proteasome.
一般的な説明
Potent reversible proteasome inhibitor (K
i = 21 nM and 35 nM for 20S and 26S proteasome, respectively).
Z-LEU-LEU-ノルバリナール 上流と下流の製品情報
原材料
準備製品