硝酸ガリウム 化学特性,用途語,生産方法
効能
カルシウム制御薬
使用
Regulator (calcium).
臨床応用
Gallium nitrate (Ganite) has been approved for the treatment of hypercalcemia of malignancy in patients
that do not respond to hydration. Its effectiveness stems from its ability to inhibit bone resorption despite the
presence of tumor-derived factors that promote calcium loss from the bone. Administered by infusion over 24
hours, the typical dose is 200 mg/m2
/day for five consecutive days. A lower dose is recommended if the
symptoms of hypercalcemia are mild (100 mg/m2
/day for 5 days). Steady state is achieved in 24 to 48 hours.
Maintenance of patient hydration is essential during treatment.
代謝
Gallium nitrate is not significantly metabolized
and is largely excreted through the kidneys. It is contraindicated in patients with severe renal impairment.
Renal function should be closely monitored in all patients receiving this agent.
硝酸ガリウム 上流と下流の製品情報
原材料
準備製品