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ジベカシン

ジベカシン 化学構造式
34493-98-6
CAS番号.
34493-98-6
化学名:
ジベカシン
别名:
6-O-(3-アミノ-3-デオキシ-α-D-グルコピラノシル)-4-O-(2,6-ジアミノ-2,3,4,6-テトラデオキシ-α-D-erythro-ヘキソピラノシル)-2-デオキシ-D-ストレプタミン;ジベカシン;デベカシン;ジデオキシカナマイシンB;3',4'-ジデオキシカナマイシンB
英語化学名:
Dibekacin
英語别名:
DIBEKACIN;Aids070753;Brn 1441606;Aids-070753;4)]-2-deoxy-;D-StreptaMine,O-3-aMino-3-deoxy-a-D-glucopyranosyl-(1®6)-O-[2,6-diaMino-2,3,4,6-tetradeoxy-a-D-erythro-hexopyranosyl-(1®6-O-(3-Amino-3-deoxy-α-D-glucopyranosyl)-4-O-(2,6-diamino-2,3,4,6-tetradeoxy-α-D-erythro-hexopyranosyl)-2-deoxy-D-streptamine;O-3-AMino-3-deoxy-α-D-glucopyranosyl-(1→6)-O-[2,6-diaMino-2,3,4,6-tetradeoxy-α-D-erythro-hexopyranosyl-(1→4)]-2-deoxy-D-streptaMine;D-Streptamine, o-3-amino-3-deoxy-alpha-D-glucopyranosyl-(1-6)-o-(2,6-diamino-2,3,4,6-tetradeoxy-alpha-D-erythro-hexopyranosyl)-(1-4)-2-deoxy-
CBNumber:
CB02130442
化学式:
C18H37N5O8
分子量:
451.52
MOL File:
34493-98-6.mol

ジベカシン 物理性質

比旋光度 :
D20 +132° (c = 0.65)
沸点 :
559.28°C (rough estimate)
比重(密度) :
1.3132 (rough estimate)
屈折率 :
1.7600 (estimate)

安全性情報

毒性 LD50 in mice (mg/kg): 61.0-68.0 i.v., 373.0-380.0 i.m. (Komiya)

ジベカシン 価格

メーカー 製品番号 製品説明 CAS番号 包装 価格 更新時間 購入

ジベカシン 化学特性,用途語,生産方法

効能

抗生物質, タンパク質合成阻害薬

定義

ChEBI: A kanamycin that is kanamycin B lacking the 3- and 4-hydroxy groups on the 2,6-diaminosugar ring.

抗菌性

3′,4′-Dideoxy kanamycin B. A semisynthetic aminoglycoside closely related to the natural compound tobramycin (3′-deoxy kanamycin B). Supplied as the sulfate.
It is active against staphylococci including methicillinresistant strains, a wide range of enterobacteria, Acinetobacter and Pseudomonas spp. It is also active against M. tuberculosis and the M. avium complex (MICs 4–16 mg/L). It exhibits the usual aminoglycoside properties of bactericidal activity at concentrations close to the MIC and bactericidal synergy with selected β-lactam antibiotics.
Absence of hydroxyl groups present in the parent kanamycin B renders dibekacin resistant to phosphorylation by APH(3′). It is also resistant to some forms of ANT(4′). However, the type of this enzyme, ANT(4′), found in some Gram-positive organisms modifies dibekacin at the 2″-hydroxyl group; nevertheless dibekacin has much greater activity than tobramycin against organisms that produce the enzyme.
A 1 mg/kg intravenous bolus dose achieves a peak plasma concentration of around 5 mg/L. The plasma half-life is 2.3 h. Protein binding is 3–12%. It is eliminated principally by the renal route, 75–80% of the dose appearing in the urine in the first 24 h. Elimination is inversely related to renal function. In patients maintained on chronic hemodialysis, the half-life rises to 54 h between dialyses and falls to 6–7 h on dialysis.
Toxic effects are those typical of aminoglycosides with a frequency similar to or less than those of gentamicin.
It is used for severe infections caused by susceptible microorganisms, especially those resistant to established aminoglycosides, but availability is limited.

安全性プロファイル

Poison by intraperitoneal, subcutaneous, intramuscular, and intravenous routes. Moderately toxic by ingestion. Experimental teratogenic and reproductive effects. An antibacterial agent. When heated to decomposition it emits toxic fumes of NOx.

ジベカシン 上流と下流の製品情報

原材料

準備製品


ジベカシン 生産企業

Global( 5)Suppliers
名前 電話番号 ファックス番号 電子メール 国籍 製品カタログ 優位度
Shenzhen Enzan Biomedical Co., Ltd. 075525325458
zhangkun@enzymepharm.com.cn CHINA 58 58
Beijing HuaMeiHuLiBiological Chemical 010-56205725;010-86181995
010-65763397 waley188@sohu.com China 12343 58
Chizhou Kailong Import and Export Trade Co., Ltd. Please Email
- xg01_gj@163.com China 9567 50
Alfa Chemistry 1-201-478-8534
1-516-927-0118 inquiry@alfa-chemistry.com United States 9944 60
Wuhan HongxinKang Fine Chemical Co., Ltd. 18672345876
027-59721024 richer3322@163.com China 1861 58

34493-98-6(ジベカシン)キーワード:


  • 34493-98-6
  • DIBEKACIN
  • (2R,3R,4S,5S,6R)-4-Amino-2-[(1S,2S,3R,4S,6R)-4,6-diamino-3-[(2R,3R,6S)-3-amino-6-(aminomethyl)oxan-2-yl]oxy-2-hydroxy-cyclohexyl]oxy-6-(hydroxymethyl)oxane-3,5-diol
  • 6-O-(3-Amino-3-deoxy-α-D-glucopyranosyl)-4-O-(2,6-diamino-2,3,4,6-tetradeoxy-α-D-erythro-hexopyranosyl)-2-deoxy-D-streptamine
  • Aids070753
  • Aids-070753
  • Brn 1441606
  • D-Streptamine, o-3-amino-3-deoxy-alpha-D-glucopyranosyl-(1-6)-o-(2,6-diamino-2,3,4,6-tetradeoxy-alpha-D-erythro-hexopyranosyl)-(1-4)-2-deoxy-
  • O-3-AMino-3-deoxy-α-D-glucopyranosyl-(1→6)-O-[2,6-diaMino-2,3,4,6-tetradeoxy-α-D-erythro-hexopyranosyl-(1→4)]-2-deoxy-D-streptaMine
  • 4)]-2-deoxy-
  • 6)-O-[2,6-diaMino-2,3,4,6-tetradeoxy-a-D-erythro-hexopyranosyl-(1®
  • D-StreptaMine,O-3-aMino-3-deoxy-a-D-glucopyranosyl-(1®
  • (2S,3R,4S,5S,6R)-4-amino-2-[(1S,2S,3R,4S,6R)-4,6-diamino-3-[(2R,3R,6S)-3-amino-6-(aminomethyl)oxan-2-yl]oxy-2-hydroxycyclohexyl]oxy-6-(hydroxymethyl)oxane-3,5-diol
  • 6-O-(3-アミノ-3-デオキシ-α-D-グルコピラノシル)-4-O-(2,6-ジアミノ-2,3,4,6-テトラデオキシ-α-D-erythro-ヘキソピラノシル)-2-デオキシ-D-ストレプタミン
  • ジベカシン
  • デベカシン
  • ジデオキシカナマイシンB
  • 3',4'-ジデオキシカナマイシンB
  • アミノグリコシド系抗生物質
  • 眼科用薬
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