フィダキソマイシン
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- CAS番号.
- 873857-62-6
- 化学名:
- フィダキソマイシン
- 别名:
- フィダキソマイシン;フィダキソマイシン (JAN);(8S,11S,12R,18S)-3-[[4-O-(3,5-ジクロロ-2-エチル-4,6-ジヒドロキシベンゾイル)-2-O-メチル-6-デオキシ-β-D-マンノピラノシル]オキシメチル]-12-[[4-O-(2-メチルプロパノイル)-5-メチル-6-デオキシ-β-D-マンノピラノシル]オキシ]-11-エチル-18-[(R)-1-ヒドロキシエチル]-8-ヒドロキシ-9,13,15-トリメチルオキサシクロオクタデカ-3,5,9,13,15-ペンタエン-2-オン;リピアルマイシンA3;(2R,3S,4S,5S,6R)-6-{[(8S,11S,12R,18S)-12-{[(2R,3S,4R,5S)-3,4-ジヒドロキシ-6,6-ジメチル-5-[(2-メチルプロパノイル)オキシ]オキサン-2-イル]オキシ}-11-エチル-8-ヒドロキシ-18-[(1R)-1-ヒドロキシエチル]-9,13,15-トリメチル-2-オキソ-1-オキサシクロオクタデカ-3,5,9,13,15-ペンタエン-3-イル]メトキシ}-4-ヒドロキシ-5-メトキシ-2-メチルオキサン-3-イル 3,5-ジクロロ-2-エチル-4,6-ジヒドロキシベンゾアート;チアクマイシンB
- 英語名:
- FidaxoMicin
- 英語别名:
- Fidaxomicin Crystalline;Dificid;OPT-80;CS-741;PAR-101;fedamycin;FidaxoMicin;Fidaxomycin;FidaxoMicinr;Not for drug
- CBNumber:
- CB02582922
- 化学式:
- C52H74Cl2O18
- 分子量:
- 1058.04
- MOL File:
- 873857-62-6.mol
- MSDS File:
- SDS
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フィダキソマイシン 物理性質
- 融点 :
- 161 °C
- 沸点 :
- 1046.4±65.0 °C(Predicted)
- 比重(密度) :
- 1.33
- 貯蔵温度 :
- 2-8°C
- 溶解性:
- クロロホルム（微量、加熱）、DMSO（微量、加熱）、メタノール（微量）
- 外見 :
- 粉
- 酸解離定数(Pka):
- 5.09±0.35(Predicted)
- 色:
- ホワイトからオフホワイト
フィダキソマイシン 価格
もっと(7)
| メーカー |
製品番号 |
製品説明 |
CAS番号 |
包装 |
価格 |
更新時間 |
購入 |
|
富士フイルム和光純薬株式会社(wako)
|
W01TRCF335400 |
フィダキソマイシン
Fidaxomicin |
873857-62-6 |
1mg |
￥18300 |
2024-03-01 |
購入 |
|
富士フイルム和光純薬株式会社(wako)
|
W01TRCF335400 |
フィダキソマイシン
Fidaxomicin |
873857-62-6 |
2mg |
￥28600 |
2023-06-01 |
購入 |
|
東京化成工業
|
F1216 |
フィダキソマイシン >98.0%(HPLC)
Fidaxomicin
>98.0%(HPLC) |
873857-62-6 |
25mg |
￥11600 |
2024-03-01 |
購入 |
|
東京化成工業
|
F1216 |
フィダキソマイシン >98.0%(HPLC)
Fidaxomicin
>98.0%(HPLC) |
873857-62-6 |
100mg |
￥35800 |
2024-03-01 |
購入 |
|
Sigma-Aldrich Japan
|
SML1750 |
≥98% (HPLC)
Fidaxomicin ≥98% (HPLC) |
873857-62-6 |
1mg |
￥70400 |
2024-03-01 |
購入 |
フィダキソマイシン 化学特性,用途語,生産方法
外観
白色～うすい黄色粉末～結晶
効能
抗生物質, タンパク質合成阻害薬
商品名
ダフクリア (アステラス製薬)
説明
Fidaxomicin (OPT-80) was approved by the U.S. FDA in May 2011 for
the treatment of Clostridium difficile-associated diarrhea (CDAD), joining
metronidazole and vancomycin as drugs recommended for treatment of
C. difficile infections (CDI). Fidaxomicin, also known as
lipiarmycin and tiacumicin, is an 18-membered macrolide natural
product that was first reported in mid-1970s and is produced by
fermentation. Fidaxomicin and its primary metabolite OP-1118,
which results from hydrolysis of the isobutyryl ester, are narrowspectrum
antibacterial agents with activity against gram-positive aerobic
and anaerobic organisms, but not against gram-negative organisms.
Fidaxomicin and OP-1118 exert their antibacterial activity by inhibiting
bacterial RNA polymerase, thereby inhibiting bacterial protein
synthesis.
The MIC90 (minimum inhibitory concentration to kill 90% of
bacteria) for fidaxomicin against C.difficile is 0.125–0.25 μg/mL; OP-
1118 is 4- to 16-fold less potent than the parent compound.
Fidaxomicin has been reported to spare native intestinal flora such as
Bacteroides spp. and as such, may prevent selection of drug-resistant
bacteria. Fidaxomicin is bactericidal to C. difficile and has a low
propensity for resistance development with no cross-resistance to
existing antibiotics. Fidaxomicin shows minimal systemic absorption following oral administration in preclinical studies and humans.
使用
Fidaxomicin is a recently marketed antibiotic with a confusing history dating back to its original isolation in 1975. Fidaxomicin is the major analogue of a family of macrocyclic lactones, isolated independently by three different groups from cultures belonging to three different genera (Actinoplanes, Dactylosporangium and Micromonospora) known as lipiarmycin A3, tiacumicin B and clostomicin B1, respectively. Fidaxomicin is a narrow spectrum antibiotic with excellent activity against Gram positive bacteria, notably Clostridium difficile. Fidaxomicin acts in the gastrointestinal tract without undue disruption to gut microbial flora.
定義
ChEBI: An 18-membered macrolide that is a fermentation product obtained from the Actinomycete Dactylosporangium aurantiacum. A narrow spectrum antibiotic used for treatment of Clostridium difficile-related infections.
応用例（製薬）
Formerly known as difimicin. An 18-membered macrocyclic
compound related to the tiacumicin group of antibiotics
rather than conventional macrolides. It is active against
staphylococci (MIC 0.5–2 mg/L) and most anaerobic Grampositive
bacilli and cocci, but Gram-negative bacilli, including
Gram-negative anaerobes, are resistant. It is very poorly
absorbed when given orally and most interest surrounds its
activity against C. difficile (MIC 0.12–0.25 mg/L). Such data
as are presently available from clinical trials suggest that it is
as safe and effective in the treatment of C. difficile-associated
diarrhea as vancomycin.
フィダキソマイシン 上流と下流の製品情報
原材料
準備製品
フィダキソマイシン 生産企業
Global( 265)Suppliers
フィダキソマイシン スペクトルデータ(1HNMR)
873857-62-6(フィダキソマイシン)キーワード:
ピマリシン
シクロフォスファミド
スピラマイシン
リラグルチド
ピメチルクロリムス(ELIエリデル
ソホスブビル
リバーロキサバン
(2R)-2,3,4a,5aβ,6,7,8,9,9aα,10aβ-デカヒドロ-4aβ,7β,9α-トリヒドロキシ-2α-メチル-6β,8β-ビス(メチルアミノ)-4H-ピラノ[2,3-b][1,4]ベンゾジオキシン-4-オン·2塩酸塩
Nインテダニブ
VE821
CP945598塩酸塩
ベリパリブ
4-クロロ-N-[2-[[5-(トリフルオロメチル)-2-ピリジニル]スルホニル]エチル]ベンズアミド
オラパリブ
- 873857-62-6
- FidaxoMicin
- 3-(((6-Deoxy-4-O-(3,5-dichloro-2-ethyl-4,6-dihydroxybenzoyl)-2-O-methyl-b-D-mannopyranosyl)oxy)-methyl)-12(R)-[(6-deoxy-5-C-methyl-4-O-(2-methyl-1-oxopropyl)-b-D-lyxo-hexopyranosyl)oxy]-11(S)-ethyl-8(S)-hydroxy-18(S)-(1(R)-hydroxyethyl)-9,13,15-trimethyloxacyclooctadeca-3,5,9,13,15-pentaene-2-one
- OPT-80
- PAR-101
- R-Tiacumicin B
- Oxacyclooctadeca-3,5,9,13,15-pentaen-2-one, 3-[[[6-deoxy-4-O-(3,5-dichloro-2-ethyl-4,6-dihydroxybenzoyl)-2-O-methyl-β-D-mannopyranosyl]oxy]methyl]-12-[[6-deoxy-5-C-methyl-4-O-(2-methyl-1-oxopropyl)-β-D-lyxo-hexopyranosyl]oxy]-11-ethyl-8-hydroxy-18-[(1R)-1-hydroxyethyl]-9,13,15-trimethyl-, (3E,5E,8S,9E,11S,12R,13E,15E,18S)-
- 3-(((6-Deoxy-4-O-(3,5-dichloro-2-ethyl-4,6-dihydroxybenzoyl)-2-O-methyl-b-D-mannopyranosyl)oxy)-methyl)-12(R)-[(6-deoxy-5-C-methyl-4-O-(2-methyl-1-oxopropyl)-b-D-lyxo-hexopyranosyl)oxy]-11(S)-eth
- Fidaxomicin
R-Tiacumicin B
- 3-(((6-Deoxy-4-O-(3,5-dichloro-2-ethyl-4,6-dihydroxybenzoyl)-2-O-methyl-b-D-mannopyranosyl)oxy)-methyl)-12(R)-[(6-deoxy-5-C-methyl-4-O-(2-methyl-1-oxopropyl)-b-D-lyxo-hexopyranosyl)oxy]-11(S)-ethyl-8(S)-hydro
- Fidaxomycin
- Fidaxomicin, >=98%
- FidaxoMicin(LipiarMycin)
- ClostoMicin B1, LipiarMycin A3, TiacuMicin B, OPT 80
- 3-(((6-Deoxy-4-O-(3,5-dichloro-2-ethyl-4,6-dihydroxybenzoyl)-2-O-methyl-β-D-mannopyranosyl)oxy)-methyl)-12(R)-[(6-deoxy-5-C-methyl-4-O-(2-methyl-1-oxopropyl)-β-D-lyxo-hexopyranosyl)oxy]-11(S)-ethyl-8(S)-hydroxy-18(S)-(1(R)-hydroxy
- 3-(((6-Deoxy-4-O-(3,5-dichloro-2-ethyl-4,6-dihydroxybenzoyl)-2-O-methyl-β-D-mannopyranosyl)oxy)-methyl)-12(R)-[(6-deoxy-5-C-methyl-4-O-(2-methyl-1-oxopropyl)-β-D-lyxo-hexopyranosyl)oxy]-11(S)-ethyl-8(S)-hydroxy-18(S)-(1(R)-hydroxyethyl)-9,13,15-trimethyloxacyclooctadeca-3,5,9,13,15-pentaene-2-one
- Fidaxomicin (OPT-80)
- Clostomicin B1
- OPT-80;PAR-101;CLOSTOMICIN B1;TIACUMICIN B
- CS-741
- fidaxomicin,Dificid
- Oxacyclooctadeca-3,5,9,13,15-pentaen-2-one, 3-[[[6-deoxy-4-O-(3,5-dichloro-2-ethyl-4,6-dihydroxybenzoyl)-2-O-methyl-β-D-mannopyranosyl]oxy]methyl]-12-[[6-deoxy-5-C-methyl-4-O-(2-methyl-1-oxopropyl)-β-D-lyxo-hexopyranosyl]oxy]-11-ethyl-8-hydroxy-18-[(1R)-1-hydroxyethyl]-9,13,15-trimethyl-, (3E,5E,8S,...
- Lipiarmycin A3
- FidaxoMicin USP/EP/BP
- FidaxoMicinr
- US-DMF No.: 028803
- FidaxomicinQ: What is
Fidaxomicin Q: What is the CAS Number of
Fidaxomicin Q: What is the storage condition of
Fidaxomicin Q: What are the applications of
Fidaxomicin
- Fidaxomicin D7Q: What is
Fidaxomicin D7 Q: What is the CAS Number of
Fidaxomicin D7 Q: What is the storage condition of
Fidaxomicin D7 Q: What are the applications of
Fidaxomicin D7
- Dificid
- Not for drug
- Fidaxomicin Crystalline
- フィダキソマイシン
- フィダキソマイシン (JAN)
- (8S,11S,12R,18S)-3-[[4-O-(3,5-ジクロロ-2-エチル-4,6-ジヒドロキシベンゾイル)-2-O-メチル-6-デオキシ-β-D-マンノピラノシル]オキシメチル]-12-[[4-O-(2-メチルプロパノイル)-5-メチル-6-デオキシ-β-D-マンノピラノシル]オキシ]-11-エチル-18-[(R)-1-ヒドロキシエチル]-8-ヒドロキシ-9,13,15-トリメチルオキサシクロオクタデカ-3,5,9,13,15-ペンタエン-2-オン
- リピアルマイシンA3
- (2R,3S,4S,5S,6R)-6-{[(8S,11S,12R,18S)-12-{[(2R,3S,4R,5S)-3,4-ジヒドロキシ-6,6-ジメチル-5-[(2-メチルプロパノイル)オキシ]オキサン-2-イル]オキシ}-11-エチル-8-ヒドロキシ-18-[(1R)-1-ヒドロキシエチル]-9,13,15-トリメチル-2-オキソ-1-オキサシクロオクタデカ-3,5,9,13,15-ペンタエン-3-イル]メトキシ}-4-ヒドロキシ-5-メトキシ-2-メチルオキサン-3-イル 3,5-ジクロロ-2-エチル-4,6-ジヒドロキシベンゾアート
- チアクマイシンB