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(2R,3R)-3-(2,5-Difluorophenyl)-3-hydroxy-2-Methyl-4-(1H-1,2,4-triazol-1-yl)thiobutyraMide

化学構造式
368421-58-3
CAS番号.
368421-58-3
化学名:
别名:
英語名:
(2R,3R)-3-(2,5-Difluorophenyl)-3-hydroxy-2-Methyl-4-(1H-1,2,4-triazol-1-yl)thiobutyraMide
英語别名:
(2R,3R)-3-(2,5-difluorophenyl)-3-hydroxy-2-Methyl-4-(1H-1,2,4-triazol-1-yl)butanethioaMide;(2S,3S)-3-(2,5-difluorophenyl)-3-hydroxy-2-methyl-4-(1H-1,2,4-triazol-1-yl)butanethioamide; 368421-58-3;1H-1,2,4-Triazole-1-butanethioamide, β-(2,5-difluorophenyl)-β-hydroxy-α-methyl-, (αR,βR)-;3R)-3-(2;ISAVUCONAZOLE IST-1;Isavuconazole Impuirty G;Isavuconazole Impurity G;Ixaconazole intermediate;Aishakang Intermediate 8
CBNumber:
CB02709066
化学式:
C13H14F2N4OS
分子量:
312.34
MOL File:
368421-58-3.mol

(2R,3R)-3-(2,5-Difluorophenyl)-3-hydroxy-2-Methyl-4-(1H-1,2,4-triazol-1-yl)thiobutyraMide 物理性質

融点 :
198-200oC
沸点 :
536.4±60.0 °C(Predicted)
比重(密度) :
1.43±0.1 g/cm3(Predicted)
貯蔵温度 :
Sealed in dry,Room Temperature
溶解性:
クロロホルム（微量）、DMSO（微量）、メタノール（微量）
外見 :
個体
酸解離定数(Pka):
11.54±0.29(Predicted)
色:
オフホワイト
CAS データベース:
368421-58-3
安全性情報
  • リスクと安全性に関する声明
  • 危険有害性情報のコード(GHS)
絵表示（GHS） GHS hazard pictograms
注意喚起語 警告
危険有害性情報
コード 危険有害性情報 危険有害性クラス 区分 注意喚起語 シンボル P コード
H302 飲み込むと有害 急性毒性、経口 4 警告 GHS hazard pictograms P264, P270, P301+P312, P330, P501
注意書き
P280 保護手袋/保護衣/保護眼鏡/保護面を着用するこ と。
P305+P351+P338 眼に入った場合：水で数分間注意深く洗うこと。次にコ ンタクトレンズを着用していて容易に外せる場合は外す こと。その後も洗浄を続けること。

(2R,3R)-3-(2,5-Difluorophenyl)-3-hydroxy-2-Methyl-4-(1H-1,2,4-triazol-1-yl)thiobutyraMide 価格 もっと(7)

メーカー 製品番号 製品説明 CAS番号 包装 価格 更新時間 購入
富士フイルム和光純薬株式会社(wako) W01COBQJ-7004
(2R,3R)-3-(2,5-Difluorophenyl)-3-hydroxy-2-methyl-4-(1h-1,2,4-triazol-1-yl)butanethioamide 		368421-58-3 1g ￥20000 2024-03-01 購入
富士フイルム和光純薬株式会社(wako) W01COBQJ-7004
(2R,3R)-3-(2,5-Difluorophenyl)-3-hydroxy-2-methyl-4-(1h-1,2,4-triazol-1-yl)butanethioamide 		368421-58-3 5g ￥65000 2024-03-01 購入
富士フイルム和光純薬株式会社(wako) W01FLC466818
(2R,3R)-3-(2,5-DIFLUOROPHENYL)-3-HYDROXY-2-METHYL-4-(1H-1,2,4-TRIAZOL-1-YL)BUTANETHIOAMIDE 		368421-58-3 1g ￥63100 2021-03-23 購入
富士フイルム和光純薬株式会社(wako) W01COBQJ-7004
(2R,3R)-3-(2,5-Difluorophenyl)-3-hydroxy-2-methyl-4-(1h-1,2,4-triazol-1-yl)butanethioamide 		368421-58-3 100mg ￥576000 2020-09-21 購入
富士フイルム和光純薬株式会社(wako) W01FLC466818
(2R,3R)-3-(2,5-DIFLUOROPHENYL)-3-HYDROXY-2-METHYL-4-(1H-1,2,4-TRIAZOL-1-YL)BUTANETHIOAMIDE 		368421-58-3 5g ￥189400 2021-03-23 購入

(2R,3R)-3-(2,5-Difluorophenyl)-3-hydroxy-2-Methyl-4-(1H-1,2,4-triazol-1-yl)thiobutyraMide 化学特性,用途語,生産方法

使用

(2R,3R)-3-(2,5-Difluorophenyl)-3-hydroxy-2-methyl-4-(1H-1,2,4-triazol-1-yl)thiobutyramide is an intermediate in the synthesis of Isavuconazole (I777830), an triazole based antifungal agent for the treatment of invasive fungal infections.

合成

(2R,3R)-3-(2,5-Difluorophenyl)-3-hydroxy-2-Methyl-4-(1H-1,2,4-triazol-1-yl)thiobutyraMide is prepared by passing (2S,3R)-3-(2,5-difluorophenyl)-3-hydroxy-2-methyl-4-(1H-1,2,4-triazol-1-yl)butyronitrile and O,O-Diethyl hydrogen phosphorodithioate through the following steps.
Step 1: (2S,3R)-3-(2,5-difluorophenyl)-3-hydroxy-2-methyl-4-(1H-1,2,4-triazol-1-yl)butyronitrile; O,O-Diethyl hydrogen phosphorodithioate In water; isopropyl alcohol at 78℃; for 15h;
Step 2: With sodium hydroxide In dichloromethane; water at 20℃; pH=7-8.説明図

(2R,3R)-3-(2,5-Difluorophenyl)-3-hydroxy-2-Methyl-4-(1H-1,2,4-triazol-1-yl)thiobutyraMide 上流と下流の製品情報

原材料

準備製品

(2R,3R)-3-(2,5-Difluorophenyl)-3-hydroxy-2-Methyl-4-(1H-1,2,4-triazol-1-yl)thiobutyraMide 生産企業

Global( 248)Suppliers
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  スペクトルデータ(1HNMR)

(2R,3R)-3-(2,5-Difluorophenyl)-3-hydroxy-2-Methyl-4-(1H-1,2,4-triazol-1-yl)thiobutyraMide(368421-58-3)1HNMR

368421-58-3()キーワード:

アイサブコナゾニウム硫酸塩
  • 368421-58-3
  • (2R,3R)-3-(2,5-Difluorophenyl)-3-hydroxy-2-Methyl-4-(1H-1,2,4-triazol-1-yl)thiobutyraMide
  • NaMe:Isavuconazole interMediate 8
  • (2R,3R)-3-(2,5-difluorophenyl)-3-hydroxy-2-methyl-4-(1H-1,2,4-triazol-1-yl)butanethioamide hydrosulfate monohydrate
  • Isavuconazole intermediate 8
  • (2R,3R)-3-(2,5-Difluorophenyl)-3-hydroxy-2-methyl-4-(1H-1,2,4-triazol-1-yl)butanethioamide Hydrate Hydrosulfate
  • (2R,3R)-3-(2,5-Difluorophenyl)-3-hydroxy-2-Methyl-4-(1H-1,2,4-triazol-1-yl)thiobutyraMid
  • (2R,3R)-3-(2,5-Difluorophenyl)-3-hydroxy-2-Methyl-4-(1H-1,2,4-triazol-1-yl)thiobutraMide
  • Isavuconazole intermediate 8 ? ?(2R,3R)-3-(2,5-Difluorophenyl)-3-hydroxy-2-methyl-4-(1H-1,2,4-triazol-1-yl)thiobutyramide
  • Isoxaconazole Intermediate 8
  • 3R)-3-(2
  • 4-triazol-1-yl)thiobutyraMide
  • 5-Difluorophenyl)-3-hydroxy-2-Methyl-4-(1H-1
  • Isavuconazole Impuirty G
  • ISAVUCONAZOLE IST-1
  • Isavuconazole Impurity G
  • (2R,3R)-3-(2,5-Difluorophenyl)-3-hydroxy-2-methyl-4-(1H-1,2,...
  • (2R,3R)-3-(2,5-difluorophenyl)-3-hydroxy-2-Methyl-4-(1H-1,2,4-triazol-1-yl)butanethioaMide
  • (2S,3S)-3-(2,5-difluorophenyl)-3-hydroxy-2-methyl-4-(1H-1,2,4-triazol-1-yl)butanethioamide
  • 368421-58-3
  • 1H-1,2,4-Triazole-1-butanethioamide, β-(2,5-difluorophenyl)-β-hydroxy-α-methyl-, (αR,βR)-
  • Ixaconazole intermediate
  • (2R,3R)-3-(2,5-Difluorophenyl)-3-hydroxy-2-Methyl-4-(1H-1,2,4-triazol-1-yl)thiobutyraMideIsavuconazole intermediate 8
  • (2R,3R)-3-(2,5 di fluorophenyl) -3-hydroxy -2-methyl-4-(1,2,4-triazol -1- yl)butanethioamide
  • (2R, 3R) -3- (2,5-difluorophenyl) -3-hydroxy-2-methyl-4- (1H-1,2,4-triazol-1-yl) thiobutanamide
  • Aishakang Intermediate 8
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