オムビタスビル
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- CAS番号.
- 1258226-87-7
- 化学名:
- オムビタスビル
- 别名:
- オムビタスビル;メチル N-[(2S)-1-[(2S)-2-({4-[(2S,5S)-1-(4-tert-ブチルフェニル)-5-{4-[(2S)-1-[(2S)-2-[(メトキシカルボニル)アミノ]-3-メチルブタノイル]ピロリジン-2-アミド]フェニル}ピロリジン-2-イル]フェニル}カルバモイル)ピロリジン-1-イル]-3-メチル-1-オキソブタン-2-イル]カルバマート;N,N′-[1-(4-tert-ブチルフェニル)-2α,5β-ピロリジンジイルビス(1,4-フェニレン)]ビス[(2S)-1-[(2S)-2-(メトキシカルボニルアミノ)-3-メチルブチリル]ピロリジン-2-カルボアミド];N,N′-[[(2S,5S)-1-(4-tert-ブチルフェニル)ピロリジン-2,5-ジイル]ビス(1,4-フェニレン)]ビス[(2S)-1-[(2S)-2-(メトキシカルボニルアミノ)-3-メチルブチリル]ピロリジン-2-カルボアミド];ABT-267
- 英語名:
- ABT-267
- 英語别名:
- Ontave;ABT-267;ombitasvir;Mr. He wei;Viekira Pak);ABT-267/Ombitasvir;Ombitasvir(ABT-267);Ombitasvir, Paritaprevir, and Ritonavir;2,2'-[[(2S,5S)-1-[4-(1,1-Dimethylethyl)phenyl]-2,5-pyrrolidinediyl]di-4,1-phenylene]bis[N-(methoxycarbonyl)-L-valyl-L-prolinamide;L-Prolinamide, 2,2'-[[(2S,5S)-1-[4-(1,1-dimethylethyl)phenyl]-2,5-pyrrolidinediyl]di-4,1-phenylene]bis[N-(methoxycarbonyl)-L-valyl-
- CBNumber:
- CB02716109
- 化学式:
- C50H67N7O8
- 分子量:
- 894.11
- MOL File:
- 1258226-87-7.mol
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オムビタスビル 物理性質
- 融点 :
- >177°C (dec.)
- 沸点 :
- 1065.6±65.0 °C(Predicted)
- 比重(密度) :
- 1.223±0.06 g/cm3(Predicted)
- 貯蔵温度 :
- -20°C Freezer, Under inert atmosphere
- 溶解性:
- DMSO(微量)、メタノール(微量)
- 酸解離定数(Pka):
- 10.92±0.46(Predicted)
- 外見 :
- 個体
- 色:
- オフホワイトからペールベージュ
安全性情報
- リスクと安全性に関する声明
- 危険有害性情報のコード(GHS)
オムビタスビル 価格
メーカー |
製品番号 |
製品説明 |
CAS番号 |
包装 |
価格 |
更新時間 |
購入 |
オムビタスビル 化学特性,用途語,生産方法
効能
抗ウイルス薬, NS5A阻害薬
説明
Ombitasvir hydrate is a NS5A non-nucleoside polymerase inhibitor
which is approved as part of a four drug combination for the
treatment of adults with genotype 1 hepatitis C virus infection
including those with compensated cirrhosis. The four drug
combination treatment consists of ombitasvir, paritaprevir
(XXVII), ritonavir, and dasabuvir (X). This combination treatment
is marketed as Viekira Pak and was developed by Abbvie as an
all oral treatment that eliminates the need for pegylated interferon-
a injections.
使用
Ombitasvir is a pharmaceutical drug that is used in the treatment of hepatitis C virus in patients with HCV genotype 1 infection. It inhibits an important viral phosphoprotein, NS5A, which is involved in viral replication, assembly, and secretion.
定義
ChEBI: A dipeptide derivative which is used which is in combination with dasabuvir sodium hydrate, paritaprevir and ritonavir (under the trade name Viekira Pak) for treatment of chronic hepatitis C virus genotype 1 infection as well as cirrhosis of the liver.
酵素阻害剤
This N-phenylpyrrolidine-based, pan-genotypic HCV NS5A protease inhibitor (FW = 893.14 g/mol), also named ABT-267, targets Nonstructural protein 5A (NS5A), a zinc-binding and proline-rich hydrophilic phosphoprotein that plays a key role in Hepatitis C virus RNA replication.Ombitasvir exhibits low-picomolar EC50 values against Hepatitis C virus, with superior pharmacokinetics. Although ombitasvir shows a low barrier to resistance, when given as monotherapy, co-administration with other antivirals enhances its barrier to resistance. Indeed, a 12-week, Phase- 3 study demonstrated that a multi-targeted regimen consisting of ombitasvir, dasabuvir and ribavirin is highly effective and showed a low rate of treatment discontinuation.
オムビタスビル 上流と下流の製品情報
原材料
準備製品
オムビタスビル 生産企業
Global( 105)Suppliers
- 1258226-87-7
- ABT-267
- ombitasvir
- Ombitasvir(ABT-267)
- 2,2'-[[(2S,5S)-1-[4-(1,1-Dimethylethyl)phenyl]-2,5-pyrrolidinediyl]di-4,1-phenylene]bis[N-(methoxycarbonyl)-L-valyl-L-prolinamide
- ABT-267/Ombitasvir
- L-Prolinamide, 2,2'-[[(2S,5S)-1-[4-(1,1-dimethylethyl)phenyl]-2,5-pyrrolidinediyl]di-4,1-phenylene]bis[N-(methoxycarbonyl)-L-valyl-
- Viekira Pak)
- OmbitasvirQ: What is
Ombitasvir Q: What is the CAS Number of
Ombitasvir Q: What is the storage condition of
Ombitasvir Q: What are the applications of
Ombitasvir
- Mr. He wei
- Methyl ((S)-1-((S)-2-((4-((2S,5S)-1-(4-(tert-butyl)phenyl)-5-(4-((S)-1-((methoxycarbonyl)-L-valyl)pyrrolidine-2-carboxamido)phenyl)pyrrolidin-2-yl)phenyl)carbamoyl)pyrrolidin-1-yl)-3-methyl-1-oxobutan-2-yl)carbamate
- Ontave
- Ombitasvir, Paritaprevir, and Ritonavir
- オムビタスビル
- メチル N-[(2S)-1-[(2S)-2-({4-[(2S,5S)-1-(4-tert-ブチルフェニル)-5-{4-[(2S)-1-[(2S)-2-[(メトキシカルボニル)アミノ]-3-メチルブタノイル]ピロリジン-2-アミド]フェニル}ピロリジン-2-イル]フェニル}カルバモイル)ピロリジン-1-イル]-3-メチル-1-オキソブタン-2-イル]カルバマート
- N,N′-[1-(4-tert-ブチルフェニル)-2α,5β-ピロリジンジイルビス(1,4-フェニレン)]ビス[(2S)-1-[(2S)-2-(メトキシカルボニルアミノ)-3-メチルブチリル]ピロリジン-2-カルボアミド]
- N,N′-[[(2S,5S)-1-(4-tert-ブチルフェニル)ピロリジン-2,5-ジイル]ビス(1,4-フェニレン)]ビス[(2S)-1-[(2S)-2-(メトキシカルボニルアミノ)-3-メチルブチリル]ピロリジン-2-カルボアミド]
- ABT-267