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ロルラチニブ

ロルラチニブ 化学構造式
1454846-35-5
CAS番号.
1454846-35-5
化学名:
ロルラチニブ
别名:
ロルラチニブ;ロルラチニブ (JAN)
英語化学名:
Lorlatinib (PF-06463922)
英語别名:
140539;CS-1727;Loratinib;EOS-60936;Lorbrena.;PF0643922;PF6463922;PF 6463922;PF-6463922;Lauratinib
CBNumber:
CB02716543
化学式:
C21H19FN6O2
分子量:
406.41
MOL File:
1454846-35-5.mol

ロルラチニブ 物理性質

沸点 :
675.0±55.0 °C(Predicted)
比重(密度) :
1.42±0.1 g/cm3(Predicted)
酸解離定数(Pka):
6.05±0.40(Predicted)
CAS データベース:
1454846-35-5

安全性情報

ロルラチニブ 価格 もっと(2)

メーカー 製品番号 製品説明 CAS番号 包装 価格 更新時間 購入
富士フイルム和光純薬株式会社(wako) W01TOC5640
PF 06463922
1454846-35-5 10mg ¥47000 2021-03-23 購入
富士フイルム和光純薬株式会社(wako) W01TOC5640
PF 06463922
1454846-35-5 50mg ¥201000 2018-12-26 購入

ロルラチニブ 化学特性,用途語,生産方法

用途

高親和性かつ選択的な ALK 及び ROS1 の阻害剤です。脳透過性です。

効能

抗悪性腫瘍薬, チロシンキナーゼ阻害薬

商品名

ローブレナ (ファイザー)

使用

Anaplastic lymphoma kinase (ALK) is a receptor tyrosine kinase that promotes cell proliferation and blocks apoptosis. PF-06463922 is an ATP-competitive, selective inhibitor of ALK (Ki = < 0.07 nM) and c-Ros oncogene 1 (ROS1, Ki = 0.7 nM). It has strong activity against all known ALK and ROS1 mutants identified in patients, including the EML4-L1196M mutant of ALK (Ki = < 0.02 nM). PF-06463922 is orally available, displaying inhibition of ALK phosphorylation and antitumor efficacy in a xenograft model expressing EML4-L1196M ALK. It demonstrates efficient blood-brain barrier penetration, produces brain tumor regression in mice harboring EML4-ALK tumors, and increases overall survival.[Cayman Chemical]

酵素阻害剤

This potent, dual ALK/ROS1 inhibitor (FW = 406.41 g/mol; CAS 1454846- 35-5), also named (10R)-7-amino-12-fluoro-10,15,16,17-tetrahydro- 2,10,16-trimethyl-15-oxo-2H-4,8-methenopyrazolo[4,3- h][2,5,11]benzoxadiazacyclotetradecine-3-carbonitrile, targets the protooncogene tyrosine-protein kinase ROS1 (Ki < 0.02 nM) as well as wild-type anaplastic lymphoma kinase ALKWT (Ki < 0.07 nM) and its Leu-to-Met mutant ALKL1196M (Ki of = 0.7 nM). PF-06463922 significantly inhibits cell proliferation and induces cell apoptosis in the HCC78 human NSCLC cells harboring SLC34A2-ROS1 fusions and the BaF3-CD74-ROS1 cells expressing human CD74-ROS1

ロルラチニブ 上流と下流の製品情報

原材料

準備製品


ロルラチニブ 生産企業

Global( 244)Suppliers
名前 電話番号 ファックス番号 電子メール 国籍 製品カタログ 優位度
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008615858145714
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Nanjing Finetech Chemical Co., Ltd.
025-85710122 17714198479
025-85710122 sales@fine-chemtech.com CHINA 890 55

1454846-35-5(ロルラチニブ)キーワード:


  • 1454846-35-5
  • PF0643922
  • PF-06463922
  • (10R)-7-Amino-12-fluoro-10,15,16,17-tetrahydro-2,10,16-trimethyl-15-oxo-2H-4,8-methenopyrazolo[4,3-h][2,5,11]benzoxadiazacyclotetradecine-3-carbonitrile
  • Lorlatinib,PF-06463922
  • PF-06463922, Lorlatinib
  • (R)-26-amino-55-fluoro-11,4,7-trimethyl-6-oxo-11H-3-oxa-7-aza-2(3,5)-pyridina-1(4,3)-pyrazola-5(1,2)-benzenacyclooctaphane-15-carbonitrile
  • EOS-60936
  • Loratinib
  • lee011/inc280
  • INC280INC280
  • Lorbrena.
  • PF 6463922
  • PF06463922; PF 06463922; PF-06463922; PF-6463922; PF6463922; PF 6463922; LORLATINIB; LORBRENA.
  • PF6463922
  • PF-6463922
  • Lauratinib
  • PF06463922;PF-06463922;PF 06463922
  • LAOLA TINI
  • CS-1727
  • Loratinib (PF-06463922)
  • Lorlatinib Lorlatinib
  • LORLATINIB API
  • 140539
  • 2H-4,8-Methenopyrazolo[4,3-h][2,5,11]benzoxadiazacyclotetradecine-3-carbonitrile, 7-amino-12-fluoro-10,15,16,17-tetrahydro-2,10,16-trimethyl-15-oxo-, (10R)-
  • PF 06463922 fandachem
  • Lorlatinib Powder
  • Anaplastic lymphoma kinase (ALK)
  • High Purity API Lorlatinib
  • Lorlatinib(PF0643922)
  • Lorlatinib (PF-06463922) USP/EP/BP
  • ロルラチニブ
  • ロルラチニブ (JAN)
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