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β-プロピオラクトン

β-プロピオラクトン 化学構造式
57-57-8
CAS番号.
57-57-8
化学名:
β-プロピオラクトン
别名:
β-プロピオラクトン;オキセタン-2-オン;3-ヒドロキシプロパン酸β-ラクトン;1,3-プロピオラクトン;ベタプロン;プロパノリド;3-プロパノリド;3-ヒドロキシプロピオン酸ラクトン;β-プロピオノラクトン;3-ヒドロキシプロパン酸ラクトン;プロピオラクトン;3-プロピオラクトン;ヒドロアクリル酸β-ラクトン;ベータ·プロピオラクトン;βプロピオラクトン;ベータ-プロピオラクトン;プロピオラクトン, RESEARCH GRADE
英語化学名:
2-Oxetanone
英語别名:
Betaprone;NSC-21626;Oxetanone;Propanlide;2-OXETANONE;Propanilide;Propanolide;OXETANONE-2;2-Oxooxetane;Oxetan-2-one
CBNumber:
CB0275433
化学式:
C3H4O2
分子量:
72.06
MOL File:
57-57-8.mol

β-プロピオラクトン 物理性質

融点 :
-33 °C (lit.)
沸点 :
162 °C (lit.)
比重(密度) :
1.146 g/mL at 25 °C (lit.)
蒸気圧:
3 at 25 °C (NIOSH, 1997)
屈折率 :
n20/D 1.412(lit.)
闪点 :
158 °F
貯蔵温度 :
-20°C
溶解性:
Miscible with acetone, alcohol, chloroform, and ether (Windholz et al., 1983)
外見 :
Liquid
色:
Colorless liquid with a sweet but irritating odor
水溶解度 :
37 g/100 mL
Sensitive :
Moisture Sensitive
Merck :
14,7820
Henry's Law Constant:
7.6 at 25 °C (approximate - calculated from water solubility and vapor pressure)
InChIKey:
VEZXCJBBBCKRPI-UHFFFAOYSA-N
CAS データベース:
57-57-8(CAS DataBase Reference)
NISTの化学物質情報:
«beta»-Propiolactone(57-57-8)
IARC:
2B (Vol. 4, Sup 7, 71) 1999
EPAの化学物質情報:
beta-Propiolactone (57-57-8)
安全性情報
  • リスクと安全性に関する声明
  • 危険有害性情報のコード(GHS)
主な危険性  T+
Rフレーズ  45-26-36/38
Sフレーズ  53-45-99
RIDADR  UN 3382 6.1/PG 1
WGK Germany  3
RTECS 番号 RQ7350000
TSCA  Yes
国連危険物分類  6.1
容器等級  I
HSコード  29322090
有毒物質データの 57-57-8(Hazardous Substances Data)
毒性 LC50 (inhalation) for rats 25 ppm/6-h (quoted, RTECS, 1985).
消防法 危-4-3-III
化審法 (5)-11
安衛法 特化則 特定化学物質(特定第2類)
絵表示(GHS)
注意喚起語 Danger
危険有害性情報
コード 危険有害性情報 危険有害性クラス 区分 注意喚起語 シンボル P コード
H227 引火性液体 引火性液体 4 警告 P210, P280, P370+P378, P403+P235,P501
H315 皮膚刺激 皮膚腐食性/刺激性 2 警告 P264, P280, P302+P352, P321,P332+P313, P362
H319 強い眼刺激 眼に対する重篤な損傷性/眼刺激 性 2A 警告 P264, P280, P305+P351+P338,P337+P313P
H330 吸入すると生命に危険 急性毒性、吸入 1, 2 危険 P260, P271, P284, P304+P340, P310,P320, P403+P233, P405, P501
H350 発がんのおそれ 発がん性 1A, 1B 危険
注意書き
P201 使用前に取扱説明書を入手すること。
P260 粉じん/煙/ガス/ミスト/蒸気/スプレーを吸入しないこ と。
P284 呼吸用保護具を着用すること。
P304+P340 吸入した場合:空気の新鮮な場所に移し、呼吸しやすい 姿勢で休息させること。
P305+P351+P338 眼に入った場合:水で数分間注意深く洗うこと。次にコ ンタクトレンズを着用していて容易に外せる場合は外す こと。その後も洗浄を続けること。
P310 ただちに医師に連絡すること。
P320 特別な治療が緊急に必要である(このラベ ルの...を見よ)。
P405 施錠して保管すること。

β-プロピオラクトン 価格 もっと(5)

メーカー 製品番号 製品説明 CAS番号 包装 価格 更新時間 購入
富士フイルム和光純薬株式会社(wako) W01W0116-2101 β-プロピオラクトン 95.0+% (Capillary GC)
β-Propiolactone 95.0+% (Capillary GC)
57-57-8 5mL ¥5400 2021-03-23 購入
富士フイルム和光純薬株式会社(wako) W01SEV33672 プロピオラクトン, research grade
Propiolactone, research grade
57-57-8 10mL ¥64500 2021-03-23 購入
東京化成工業 H0168 β-プロピオラクトン >95.0%(GC)(T)
β-Propiolactone >95.0%(GC)(T)
57-57-8 25g ¥19600 2021-03-23 購入
東京化成工業 H0168 β-プロピオラクトン >95.0%(GC)(T)
β-Propiolactone >95.0%(GC)(T)
57-57-8 5g ¥7000 2021-03-23 購入
富士フイルム和光純薬株式会社(wako) W01W0116-2101 β-プロピオラクトン 95.0+% (Capillary GC)
β-Propiolactone 95.0+% (Capillary GC)
57-57-8 25mL ¥18100 2021-03-23 購入

β-プロピオラクトン MSDS


2-Oxetanone

β-プロピオラクトン 化学特性,用途語,生産方法

外観

無色〜ほとんど無色, 澄明の液体

溶解性

エタノール及びアセトンに極めて溶けやすく、水に溶けやすい。

用途

有機合成原料、繊維改質剤・殺菌消毒剤。

用途

医薬品、有機合成(アクリル酸及びアクリレート)、繊維改質剤、殺菌消毒剤

効能

殺菌消毒薬

説明

Beta-propiolactone is a colorless liquid with a strong, slightly sweet odor. It may occur naturally, but no clear documentation of its occurrence in nature was found, and it must be synthesized for commercial purposes. Beta-propiolactone is unstable at room temperature but stable when stored at 5 C in glass containers.
Its tendency to be unstable and react with other molecules in the vicinity is responsible for both its toxicity and its usefulness. Significant commercial production of beta-propiolactone took place during the late 1950s through the mid-1970s, when it was widely used in chemical synthesis in reactions with other molecules to produce new chemicals. All lactones are characterized by a ring structure consisting of two or more carbon atoms – as can be seen from its structure, beta-propiolactone has three in its ring – and a single oxygen, coupled with an adjacent ketone. The fewer the carbons in the ring, the more ‘strained’ is the ring structure and the more unstable and reactive its characteristics. When the ring bonds break, the betapropiolactone molecules attach to other nearby molecules.

化学的特性

β-Propiolactone is a colorless liquid which slowly hydrolyzes to hydracrylic acid and must be cooled to remain stable.

化学的特性

Colorless to light yellow liqui

使用

Reacts with bacteriphage DNA causing inactivation, repair and recombination

使用

antiandrogen

使用

Versatile intermediate in organic synthesis.

brand name

Betaprone (Forest).

一般的な説明

A colorless liquid with a slightly sweetish, pungent odor. Used as an intermediate in organic synthesis; disinfectant, sterilant for blood plasma, tissue grafts, vaccines, enzymes and surgical instruments.

空気と水の反応

Slow reaction with water to form beta- hydroxypropionic acid.

反応プロフィール

2-Oxetanone is an ester. Esters react with acids to liberate heat along with alcohols and acids. Strong oxidizing acids may cause a vigorous reaction that is sufficiently exothermic to ignite the reaction products. Heat is also generated by the interaction of esters with caustic solutions. Flammable hydrogen is generated by mixing esters with alkali metals and hydrides. 2-Oxetanone may be incompatible with alkalis.

危険性

Strong skin and upper respiratory tract irri- tant, skin cancer. Possible carcinogen. Worker expo- sure should be minimized.

健康ハザード

The toxicity potential of 2-Oxetanone via inhalation or ingestion is high; may cause death or permanent injury after very short exposures to small quantities. It is a carcinogen.

火災危険

Containers may explode. When heated to decomposition, 2-Oxetanone emits acrid smoke and fumes. Stable when stored at 41F. Avoid storing in areas of exposure to the direct rays of the sun and in areas of high fire hazard. Tends to polymerize on storage. Avoid elevated temperatures.

安全性プロファイル

Confirmed carcinogen with experimental carcinogenic, neoplastigenic, and tumorigenic data. Poison by inhalation. Moderately toxic by intraperitoneal route. An initiator. Human mutation data reported. When heated to decomposition it emits acrid smoke and irritating fumes.

職業ばく露

β-Propiolactone is used as a chemical intermediate in synthesis of acrylic acid and esters, acrylate plastics; as a vapor sterilizing agent; phase disinfectant; and a viricidal agent.

Carcinogenicity

β-Propiolactone is reasonably anticipated to be a human carcinogenbased on sufficient evidence of carcinogenicity from studies in experimental animals.

環境運命予測

Chemical/Physical. Slowly hydrolyzes to hydracrylic acid (Windholz et al., 1983). In a reactor heated to 250 °C and a pressure of 12 mmHg, β-propiolactone decomposed to give equal amounts of ethylene and carbon dioxide (James and Wellington, 1969).

輸送方法

UN3382 Toxic by inhalation liquid, n.o.s. with an LC 50 ≤1000 mL/m 3 and saturated vapor concentration ≥10 LC 50 , Hazard class: 6.1; Labels: 6.1 Technical Name Required, Inhalation Hazard Zone B. UN2810 Toxic liquids, organic, n.o.s., Hazard Class: 6.1; Labels: 6.1-Poisonous materials, Technical Name Required.

純化方法

Fractionally distil the lactone from sodium under reduced pressure. It gives an acidic solution in H2O. It irritates the skin and is a possib

Toxicity evaluation

It is soluble in water (370 g l1 at 25°C) and miscible in other common organic solvents including acetone, chloroform, diethyl ether, and ethanol (Log Kow 0.462). Hydrolysis occurs in water where the half-life in aqueous media at 25°C is approximately 3.5 h. If released to soil, relatively rapid hydrolysis can be expected to occur in the presence of moisture. Significant evaporation may occur from dry surfaces. With a vapor pressure of 3.4 mm Hg at 25°C, it can also vaporize into the air as temperature rises. If released to the atmosphere, beta-propiolactone is expected to exist in the gas phase, where it may be relatively more persistent in the absence of moisture than it is in aqueous media. The half-life for the reaction with photochemically produced hydroxyl radicals was estimated to be a relatively slow rate of 45 days in the atmosphere.

不和合性

Reacts with water, causing decomposi- tion and forming 3-hydroxypropionic acid (CAS: 503-66- 3), an irritant. Incompatible with oxidizers (chlorates, nitrates, peroxides, permanganates, perchlorates, chlorine, bromine, fluorine, etc.); contact may cause fires or explo- sions. Keep away from alkaline materials, strong bases, strong acids, oxoacids, epoxides. Incompatible with acet- ates, halogens, thiocyanates, thiosulfates, strong oxidizers; strong bases. Forms explosive mixture with air above 75℃. May polymerize upon storage or due to warming. Stable if kept under refrigeration @ 5 to 10 ℃/40 to 50 ℃.

廃棄物の処理

Dissolve or mix the material with a combustible solvent and burn in a chemical incinera- tor equipped with an afterburner and scrubber. All federal, state, and local environmental regulations must be observed.

β-プロピオラクトン 上流と下流の製品情報

原材料

準備製品


β-プロピオラクトン 生産企業

Global( 145)Suppliers
名前 電話番号 ファックス番号 電子メール 国籍 製品カタログ 優位度
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57-57-8(β-プロピオラクトン)キーワード:


  • 57-57-8
  • Beta-propiolactone, 98%, pure
  • Propiolactone research grade
  • β-Propiolactone ,98%
  • BETA-PROPIOLACTONERESEARCH GRADE
  • β-Propiolactone,3-Hydroxypropionic acid lactone, Hydracrylic acid β-lactone
  • b-Propiolactone, Reagent
  • beta-Hydroxypropionic Acid Lactone 2-Oxetanone beta-Propionolactone
  • BETA-HYDROXYPROPIONIC ACID LACTONE
  • BETA-PROPIOLACTONE
  • BETA-PROPIONOLACTONE
  • B-PROPIOLACTONE
  • HYDRACRYLIC ACID BETA-LACTONE
  • HYDRACRYLIC ACID LACTONE
  • 2-OXETANONE
  • 3-HYDROXYPROPIONIC ACID LACTONE
  • ALPHA-PROPIONOLIDE
  • 1,3-Propiolactone
  • 2-Oxacyclobutanone
  • 2-Oxooxetane
  • 3-hydroxy-propanoicacibeta-lactone
  • 3-Hydroxypropionic acid beta-lactone
  • 3-hydroxy-propionicacibeta-lactone
  • 3-hydroxypropionicacid,beta-lactone
  • 3-Propanolide
  • 3-propanolyde
  • 3-Propiolactone
  • beta-lactone hydracrylic acid
  • Betaprone
  • beta-Propanoic acid lactone
  • beta-Propiolakton
  • β-プロピオラクトン
  • オキセタン-2-オン
  • 3-ヒドロキシプロパン酸β-ラクトン
  • 1,3-プロピオラクトン
  • ベタプロン
  • プロパノリド
  • 3-プロパノリド
  • 3-ヒドロキシプロピオン酸ラクトン
  • β-プロピオノラクトン
  • 3-ヒドロキシプロパン酸ラクトン
  • プロピオラクトン
  • 3-プロピオラクトン
  • ヒドロアクリル酸β-ラクトン
  • ベータ·プロピオラクトン
  • βプロピオラクトン
  • ベータ-プロピオラクトン
  • プロピオラクトン, RESEARCH GRADE
  • オキセタン
  • ラクトン & ラクチド (高性能ポリマー研究用試薬)
  • 高性能ポリマー研究用試薬
  • 構造分類
  • 機能性材料
  • 四員環化合物
  • 殺菌薬
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