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ベルルクロゲンTR1

ベルルクロゲンTR1 化学構造式
12771-72-1
CAS番号.
12771-72-1
化学名:
ベルルクロゲンTR1
别名:
ベルクロゲン;ベルルクロゲン;ベルクロゲンTR1;ベルクロゲンTR-1;ベルルクロゲンTR1;ベルクロゲン 100ΜG/ML
英語化学名:
VERRUCULOGEN
英語别名:
tr1;T1R1;TRXR1;GPR70;TAS1R1;NA 209A;GRIM-12;MGC9145;TR-1TOXIN;VERRUCOLOGEN
CBNumber:
CB0294003
化学式:
C27H33N3O7
分子量:
511.57
MOL File:
12771-72-1.mol

ベルルクロゲンTR1 物理性質

闪点 :
2℃
貯蔵温度 :
2-8°C
外見 :
buffered aqueous solution
安全性情報
  • リスクと安全性に関する声明
  • 危険有害性情報のコード(GHS)
主な危険性  T,Xn,F
Rフレーズ  23/24/25-36-20/21/22-11
Sフレーズ  36/37/39-45-36/37-26-16
RIDADR  UN 2811 6.1/PG 2
WGK Germany  3
RTECS 番号 JH4920000
HSコード  38220090
絵表示(GHS)
注意喚起語 Danger
危険有害性情報
コード 危険有害性情報 危険有害性クラス 区分 注意喚起語 シンボル P コード
H225 引火性の高い液体および蒸気 引火性液体 2 危険 P210,P233, P240, P241, P242, P243,P280, P303+ P361+P353, P370+P378,P403+P235, P501
H319 強い眼刺激 眼に対する重篤な損傷性/眼刺激 性 2A 警告 P264, P280, P305+P351+P338,P337+P313P
注意書き
P210 熱/火花/裸火/高温のもののような着火源から遠ざ けること。-禁煙。
P261 粉じん/煙/ガス/ミスト/蒸気/スプレーの吸入を避ける こと。
P280 保護手袋/保護衣/保護眼鏡/保護面を着用するこ と。
P305+P351+P338 眼に入った場合:水で数分間注意深く洗うこと。次にコ ンタクトレンズを着用していて容易に外せる場合は外す こと。その後も洗浄を続けること。
P370+P378 火災の場合:消火に...を使用すること。
P403+P235 換気の良い場所で保管すること。涼しいところに 置くこと。

ベルルクロゲンTR1 価格 もっと(6)

メーカー 製品番号 製品説明 CAS番号 包装 価格 更新時間 購入
富士フイルム和光純薬株式会社(wako) W01LKTV1870 ベルクロゲン
Verruculogen
12771-72-1 1mg ¥31200 2021-03-23 購入
富士フイルム和光純薬株式会社(wako) W01LKTV1870 ベルクロゲン
Verruculogen
12771-72-1 5mg ¥129400 2021-03-23 購入
Sigma-Aldrich Japan SAB2700382 affinity isolated antibody, buffered aqueous solution
Anti-TAS1R1 (C-terminal) antibody produced in rabbit affinity isolated antibody, buffered aqueous solution
12771-72-1 100ul ¥53700 2018-12-25 購入
Sigma-Aldrich Japan SAB1304378 IgG fraction of antiserum, buffered aqueous solution
ANTI-TAS1R1 (CENTER) antibody produced in rabbit IgG fraction of antiserum, buffered aqueous solution
12771-72-1 400ul ¥68800 2018-12-25 購入
林純薬工業株式会社 99037016 ベルクロゲン 100μg/ml
Verruculogen, 100μg/ml in acetonitrile
12771-72-1 1ml ¥96700 2018-12-15 購入

ベルルクロゲンTR1 化学特性,用途語,生産方法

使用

Verruculogen is a tremorgenic mycotoxin, first isolated from Penicillium verruculosum in 1972. The structure was resolved as an indole alkaloid in 1974. Verruculogen is produced by several species of Penicillium and Aspergillus and its presence is a useful taxonomic phenotypic marker. The tremorgenic action of verruculogen is associated with increases in spontaneous glutamate and aspartate release, decreases in GABA levels and, at toxic doses, an increase in the number and decrease in the affinity of DHP receptors in rat cortex. In in vitro guinea pig ileum preparations, verruculogen causes an increase in contractile responses due to electrical field stimulation, attributed to enhancement of acetylcholine from presynaptic nerve terminals. Verruculogen also inhibits Ca2+-activated K+ channels, and is a cell cycle inhibitor blocking division at the M phase.

使用

Verruculogen is a tremorgenic mycotoxin isolated from species of Penicillium, Aspergillus, and other fungi. It selectively inhibits the activation of Maxi-K potassium channels by charybdotoxin with a K1/2 value of 170 nM. Verruculogen also promotes the release of excitatory neurotransmitters when injected directly into the brain of rats and, at high doses, arrests mouse mammary carcinoma cells in M phase of the cell cycle (MIC = 12.2 μM).[Cayman Chemical]

使用

Suggested starting dilutions are as follows: ICC/IF: 1:100-1:1000, IHC-P: 1:100-1:1000, WB: 1:500-1:3000. Not yet tested in other applications. Optimal working dilutions should be determined experimentally by the end user.

定義

ChEBI: An organic heterohexacyclic compound that is a mycotoxic indole alkaloid isolated from Penicillium and Aspergillus species.

Biochem/physiol Actions

The protein encoded by this gene is a G protein-coupled receptor and is a component of the heterodimeric amino acid taste receptor T1R1+3. The T1R1+3 receptor responds to L-amino acids but not to D-enantiomers or other compounds. Most amino acids that are perceived as sweet activate T1R1+3, and this activation is strictly dependent on an intact T1R1+3 heterodimer. Multiple transcript variants encoding several different isoforms have been found for this gene. [provided by RefSeq]

ベルルクロゲンTR1 上流と下流の製品情報

原材料

準備製品


ベルルクロゲンTR1 生産企業

Global( 75)Suppliers
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12771-72-1(ベルルクロゲンTR1)キーワード:


  • 12771-72-1
  • VERRUCULOGEN
  • VERRUCULOGEN, PENICILLIUM VERRUCULOSUM
  • 3h)-dione,1,10,10a,14,14a,15b-hexahydro-10,10a-dihydroxy-7-methoxy-2,2-dimeth
  • 5h,12h-3,4-dioxa-5a,11a,15a-triazacyclooct(lm)indeno(5,6-b)fluorene-11,15(2h,1
  • tr1
  • verruculogentr1
  • yl-5-(2-methyl-1-propenyl)-,(5r-(5-alpha,10-alpha,10a-alpha,14a-alpha-15b-alp
  • verruculogen from penicillium*verruculosum
  • VERRUCULOGEN FROM PENICILLIUM VERRUCULOS
  • VERRUCOLOGEN
  • TR-1TOXIN
  • (5R)-1,10,10a,14,14aα,15bα-Hexahydro-10α,10aα-dihydroxy-7-methoxy-2,2-dimethyl-5α-(2-methyl-1-propenyl)-12H-3,4-dioxa-5a,11a,15a-triazacyclooct[lm]indeno[5,6-b]fluorene-11,15(2H,13H)-dione
  • (5R)-2,5,10,10a,11,12,13,14,14aα,15bα-Decahydro-10α,10aα-dihydroxy-7-methoxy-2,2-dimethyl-5α-(2-methyl-1-propenyl)-3,4-dioxa-5a,11a,15a-triaza-1H-cyclooct[lm]indeno[5,6-b]fluorene-11,15-dione
  • (5R-(5alpha,10 alpha,10Aalpha,14aalpha,15balpha))-1,10,10A,14,14A,15B-hexahydro-10,10A-dihydroxy-7-methoxy-2,2-dimethyl-5-(2-methyl-1-propenyl)-5H,12H-3,4-dioxa-5A,11A,15A-triaza cyclooct (1m) indeno (5,6-B)fluorene-11,15(2H,13H)-dione
  • 5H,12H-3,4-Dioxa-5A,11A,15A-triazacyclooct(lm)indeno(5,6-B)fluorene-11,15(2H,13H)-dione, 1,10,10A,14,14A,15B-hexahydro-10,10A-dihydroxy-7-methoxy-2,2-dimethyl-5-(2-methyl-1-propenyl)-, (5R,10S,10ar,14as,15bs)-
  • 5H,12H-3,4-Dioxa-5A,11A,15A-triazacyclooct(lm)indeno(5,6-B)fluorene-11,15(2H,13H)-dione, 1,10,10A,14,14A,15B-hexahydro-10,10A-dihydroxy-7-methoxy-2,2-dimethyl-5-(2-methyl-1-propenyl)-,(5R-(5-alpha,10-alpha,10A-alpha,14A-alpha-15B-alpha))-
  • Verruculogenresearch grade
  • NA 209A
  • Verruculogen NA 209A TR 1 toxin
  • Verruculogen solution
  • GRIM-12
  • MGC9145
  • TRXR1
  • TXNRD1 human
  • Anti-TAS1R1 (N-terminal) antibody produced in rabbit
  • GPR70
  • T1R1
  • TAS1R1
  • ANTI-TAS1R1 (CENTER) antibody produced in rabbit
  • Taste receptor type 1 member 1
  • ベルクロゲン
  • ベルルクロゲン
  • ベルクロゲンTR1
  • ベルクロゲンTR-1
  • ベルルクロゲンTR1
  • ベルクロゲン 100ΜG/ML
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