N-アセチル-D-グルコサミン 化学特性,用途語,生産方法
外観
白色～ほとんど白色, 結晶性粉末～粉末
定義
本品は、次の化学式で表されるN-アセチル化アミノ糖である。
溶解性
水及びメタノールに溶ける。
解説
N-アセチル-D-グルコサミン,D-体のα-ピラノース形は融点205 ℃．[α]D"＋64→＋41°(水)．β-ピラノース形は融点182～183.5 ℃．[α]D"－22→＋41°(水)．エルソン-モルガン法を利用して検出，定量される．医薬品の原料に用いられる．
森北出版「化学辞典（第2版）
用途
医薬及び化粧品の原料、アミノ糖研究用。
化粧品の成分用途
皮膚コンディショニング剤
製造
N-アセチル-D-グルコサミン,略号GlcNAc．グルコサミンのアミノ基をアセチル化したもの．D-体はキチン質をはじめ，ムコ多糖，糖タンパク質，糖脂質の構成成分であり，広く生物界に分布している．水またはメタノール中グルコサミンに小過剰の無水酢酸を作用させると得られる．
説明
N-Acetyl-D-Glucosamine is the N-acetyl derivative of glucosamine.Chemically it is an amide between glucosamine and acetic acid. A single N-acetlyglucosamine moiety linked to serine or threonine residues on nuclear and cytoplasmic proteins -O-GlcNAc, is an ubiquitous post-translational protein modification. O-GlcNAc modified proteins are involved in sensing the nutrient status of the surrounding cellular environment and adjusting the activity of cellular proteins accordingly. O-GlcNAc regulates cellular responses to hormones such as insulin, initiates a protective response to stress, modulates a cell's capacity to grow and divide, and regulates gene transcription. In humans, it exists in skin, cartilage and blood vessel as a component of hyaluronic acid, and bone tissue, cornea and aorta as a component of keratan sulfate.
N-Acetyl-D-glucosamine (D-GlcNAc) is a derivitized glucose monomer found in polymers of bacterial cell walls, chitin, hyaluronic acids and various glycans. It is also synthesized in the glycosylation pathway as uridine diphosphate (UDP-GlcNAc), which can then be released following degradation of glycosylated proteins.D-GlcNAc is used to identify, differentiate and characterize N-acetyl-β-D-hexoaminidase(s). It is also used in the treatment of osteoarthritis and inflammatory bowel disease (IBD), including ulcerative colitis and Crohn's disease. Further, it is used as a substrate in sialic acid production, cosmetics and in drug development research.
化学的特性
White powder
使用
N-Acetyl-D-glucosamine is used in the identification and characterization of N-acetyl-beta-D-hexoaminidase. It is also used in the treatment of osteoarthritis and inflammatory bowel disease (IBD), including ulcerative colitis and Crohn's disease. Further, it is used as a substrate in sialic acid production, cosmetics and in drug development research.
定義
ChEBI: N-acetyl-D-glucosamine is the D isomer of N-acetylglucosamine. It has a role as a bacterial metabolite. It is a N-acetylglucosamine and a N-acetyl-D-hexosamine.
一般的な説明
N-Acetylglucosamine (GlcNAc) is a monosaccharide, derived from glucose and undergoes linear polymerization by (1,4)-β-linkages to form the polymer chitin. It is also a component of heterogenous polysaccharides, such as murein and hyaluronic acid.
N-acetylglucosamine exhibits anti-inflammatory properties and is considered as a potential drug in the treatment of osteoarthritis. Its antiarthritic mode of mechanism involves the suppression of IL-1β (Interleuken-1β)-induced NO (nitric oxide), cyclooxygenase-2 (COX-2), and IL-6 production by inhibition of expression of iNOS (inducible nitric oxide synthase) protein and mRNA.
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
N-アセチル-D-グルコサミン 上流と下流の製品情報
原材料
準備製品