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フロモキセフ

フロモキセフ 化学構造式
99665-00-6
CAS番号.
99665-00-6
化学名:
フロモキセフ
别名:
フロモキセフ;フルモキセフ;[6R,7R,(-)]-7α-[[2-(ジフルオロメチルチオ)アセチル]アミノ]-3-[[[1-(2-ヒドロキシエチル)-1H-テトラゾール-5-イル]チオ]メチル]-7-メトキシ-8-オキソ-5-オキサ-1-アザビシクロ[4.2.0]オクタ-2-エン-2-カルボン酸;フルマリン;(6R,7R)-7α-[[(ジフルオロメチル)チオ]アセチルアミノ]-7-メトキシ-8-オキソ-3-[[[1-(2-ヒドロキシエチル)-1H-テトラゾール-5-イル]チオ]メチル]-1-アザ-5-オキサビシクロ[4.2.0]オクタ-2-エン-2-カルボン酸
英語化学名:
Flomoxef
英語别名:
FMOX;Flumarin;FLOMOXEF;(6R,7R)-7α-[[(Difluoromethyl)thio]acetylamino]-7-methoxy-8-oxo-3-[[[1-(2-hydroxyethyl)-1H-tetrazol-5-yl]thio]methyl]-1-aza-5-oxabicyclo[4.2.0]oct-2-ene-2-carboxylic acid;(6R,7R)-7-[[[(DifluoroMethyl)thio]acetyl]aMino]-3-[[[1-(2-hydroxyethyl)-1H-tetrazol-5-yl]thio]Methyl]-7-Methoxy-8-oxo-5-oxa-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic Acid;(6R-cis)7-[[[(DifluoroMethyl)thio]acetyl]aMino]-3-[[[1-(2-hydroxyethyl)-1H-tetrazol-5-yl]thio]Methyl]-7-Methoxy-8-oxo-5-oxa-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic Acid;(6R-cis)-7-[[[(Difluoromethyl)thio]acetyl]amino]-3_[[[1-(2-hy-droxyethyl)-1H-tetrazol-5-y1]thio]methyl]-7-methoxy-8-oxo-5-oxa-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid;(-)-(6R,7R)-7-(2-((Difluoromethyl)thio)acetamido)-3-(((1-(2-hydroxyethyl)-1H-tetrazol-5-yl)thio)methyl)-7-methoxy-8-oxo-5-oxa-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid;(6R,7R)-7-[[2-(difluoromethylsulfanyl)acetyl]amino]-3-[[1-(2-hydroxyethyl)tetrazol-5-yl]sulfanylmethyl]-7-methoxy-8-oxo-5-oxa-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid;5-Oxa-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylicacid,7-[[2-[(difluoroMethyl)thio]acetyl]aMino]-3-[[[1-(2-hydroxyethyl)-1H-tetrazol-5-yl]thio]Methyl]-7-Methoxy-8-oxo-,(6R,7R)-
CBNumber:
CB0328847
化学式:
C15H18F2N6O7S2
分子量:
496.47
MOL File:
99665-00-6.mol

フロモキセフ 物理性質

融点 :
82.5-87.5°
CAS データベース:
99665-00-6(CAS DataBase Reference)

安全性情報

フロモキセフ 価格 もっと(3)

メーカー 製品番号 製品説明 CAS番号 包装 価格 更新時間 購入
富士フイルム和光純薬株式会社(wako) W01TRCF401850 フロモキセフ
Flomoxef
99665-00-6 0.5mg ¥93800 2018-12-26 購入
富士フイルム和光純薬株式会社(wako) W01TRCF401850 フロモキセフ
Flomoxef
99665-00-6 1mg ¥150000 2018-12-26 購入
富士フイルム和光純薬株式会社(wako) W01TRCF401850 フロモキセフ
Flomoxef
99665-00-6 5mg ¥600000 2018-12-26 購入

フロモキセフ 化学特性,用途語,生産方法

効能

抗生物質, 細胞壁合成阻害薬

説明

Flomoxef sodium is a P-lactamase resistant oxacephalosporin. Its spectrum of activity is similar to that of cefazolin and moxalactam, but with better efficacy against Staphylococcus aureus and Bacteroides fragilis. Flomoxef is reported effective in the treatment of post-operative, urinary tract and abdominal cavity infections.

Originator

Shionogi (Japan)

使用

Flomoxef is an oxacephem derived beta-lactam antibiotic that is particularly effective against gram-positive bacteria.

brand name

Flumari

抗菌性

An oxa-cephem which differs from latamoxef in the side chains carried at the 7-amino and C-3 positions, but which retains the 7-methoxy group that confers β-lactamase stability. The methyl group of the methylthiotetrazole side chain of latamoxef has been modified to hydroxymethyl in an attempt to avoid the undesirable side effects, while the side chain at the 7-amino position is F2-CH-S-CH2-.
Activity is similar to that of latamoxef, but activity against Staph. aureus is improved and it is claimed to be a poor inducer of penicillin-binding protein 2′, which is associated with resistance in methicillin-resistant strains.
Intravenous injection of 2 g achieves a peak plasma concentration of around 50 mg/L, falling to 2.6 mg/L after 6 h. The plasma half-life is about 50 min. It appears to be well distributed and penetrates moderately well into lung, mucosal tissue of the middle ear and bone.
Flomoxef does not seem to be prone to the effects on platelet function of latamoxef and it has a less marked effect on vitamin K metabolism. It does not cause a disulfiram-like reaction with alcohol.
It is available in Japan, where it appears safe and effective in a wide range of infections.

フロモキセフ 上流と下流の製品情報

原材料

準備製品


フロモキセフ 生産企業

Global( 52)Suppliers
名前 電話番号 ファックス番号 電子メール 国籍 製品カタログ 優位度
Henan DaKen Chemical CO.,LTD.
+86-371-55531817
info@dakenchem.com CHINA 21967 58
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 20680 55
Shanghai Time Chemicals CO., Ltd.
+86-021-57951555
+86-021-57951555 jack.li@time-chemicals.com CHINA 1367 55
Mainchem Co., Ltd.
+86-0592-6210733
+86-0592-6210733 sales@mainchem.com CHINA 32457 55
Nanjing Finetech Chemical Co., Ltd.
025-85710122 17714198479
025-85710122 sales@fine-chemtech.com CHINA 892 55
Chemwill Asia Co.,Ltd.
86-21-51086038
86-21-51861608 chemwill_asia@126.com;sales@chemwill.com;chemwill@hotmail.com;chemwill@gmail.com CHINA 24001 58
J & K SCIENTIFIC LTD. 400-666-7788 +86-10-82848833
+86-10-82849933 jkinfo@jkchemical.com;market6@jkchemical.com China 96815 76
LGM Pharma 1-(800)-881-8210
615-250-9817 inquiries@lgmpharma.com United States 1943 70
Chemsky (shanghai) International Co.,Ltd 021-50135380
shchemsky@sina.com China 15436 60
Hangzhou Yuhao Chemical Technology Co., Ltd 0571-82693216
+86-571-82880190 info@yuhaochemical.com China 9409 52

99665-00-6(フロモキセフ)キーワード:


  • 99665-00-6
  • (6R,7R)-7-[[2-(difluoromethylsulfanyl)acetyl]amino]-3-[[1-(2-hydroxyethyl)tetrazol-5-yl]sulfanylmethyl]-7-methoxy-8-oxo-5-oxa-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
  • FLOMOXEF
  • 5-OXA-1-AZABICYCLO[4.2.0]OCT-2-ENE-2-CARBOXYLIC ACID, 7-[[[(DIFLUOROMETHYL)THIO]ACETYL]AMINO]-3-[[[1-(2-HYDROXYETHYL)-1H-TETRAZOL-5-YL]THIO]METHYL]-7-METHOXY-8-OXO-, (6R-CIS)-
  • FLOMOXEF [5-OXA-1-AZABICYCLO[4.2.0]OCT-2-ENE-2-CARBOXYLIC ACID, 7-[[[(DIFLUOROMETHYL)THIO]ACETYL]AMINO]-3-[[[1-(2-HYDROXYETHYL)-1H-TETRAZOL-5-YL]THIO]METHYL]-7-METHOXY-8-OXO-, (6R-CIS)- ]
  • 5-Oxa-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 7-[[[(difluoromethyl)thio]acetyl]amino]-3-[[[1-(2-hydroxyethyl)-1H-tetrazol-5-yl]thio]methyl]-7-methoxy-8-oxo-, (6R,7R)-
  • Flumarin
  • FMOX
  • (-)-(6R,7R)-7-(2-((Difluoromethyl)thio)acetamido)-3-(((1-(2-hydroxyethyl)-1H-tetrazol-5-yl)thio)methyl)-7-methoxy-8-oxo-5-oxa-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
  • (6R-cis)-7-[[[(Difluoromethyl)thio]acetyl]amino]-3_[[[1-(2-hy-droxyethyl)-1H-tetrazol-5-y1]thio]methyl]-7-methoxy-8-oxo-5-oxa-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
  • (6R,7R)-7α-[[(Difluoromethyl)thio]acetylamino]-7-methoxy-8-oxo-3-[[[1-(2-hydroxyethyl)-1H-tetrazol-5-yl]thio]methyl]-1-aza-5-oxabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
  • [6R,7R,(-)]-7α-[[2-(Difluoromethylthio)acetyl]amino]-3-[[[1-(2-hydroxyethyl)-1H-tetrazol-5-yl]thio]methyl]-7-methoxy-8-oxo-5-oxa-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
  • 5-Oxa-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylicacid,7-[[2-[(difluoroMethyl)thio]acetyl]aMino]-3-[[[1-(2-hydroxyethyl)-1H-tetrazol-5-yl]thio]Methyl]-7-Methoxy-8-oxo-,(6R,7R)-
  • (6R,7R)-7-[[[(DifluoroMethyl)thio]acetyl]aMino]-3-[[[1-(2-hydroxyethyl)-1H-tetrazol-5-yl]thio]Methyl]-7-Methoxy-8-oxo-5-oxa-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic Acid
  • (6R-cis)7-[[[(DifluoroMethyl)thio]acetyl]aMino]-3-[[[1-(2-hydroxyethyl)-1H-tetrazol-5-yl]thio]Methyl]-7-Methoxy-8-oxo-5-oxa-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic Acid
  • フロモキセフ
  • フルモキセフ
  • [6R,7R,(-)]-7α-[[2-(ジフルオロメチルチオ)アセチル]アミノ]-3-[[[1-(2-ヒドロキシエチル)-1H-テトラゾール-5-イル]チオ]メチル]-7-メトキシ-8-オキソ-5-オキサ-1-アザビシクロ[4.2.0]オクタ-2-エン-2-カルボン酸
  • フルマリン
  • (6R,7R)-7α-[[(ジフルオロメチル)チオ]アセチルアミノ]-7-メトキシ-8-オキソ-3-[[[1-(2-ヒドロキシエチル)-1H-テトラゾール-5-イル]チオ]メチル]-1-アザ-5-オキサビシクロ[4.2.0]オクタ-2-エン-2-カルボン酸
  • セファロスポリン類
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