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ドキセピン塩酸塩(異性体混合物)

ドキセピン塩酸塩(異性体混合物) 化学構造式
1229-29-4
CAS番号.
1229-29-4
化学名:
ドキセピン塩酸塩(異性体混合物)
别名:
ドキセピン塩酸塩;3-[ジベンゾ[b,e]オキセピン-11(6H)-イリデン]-N,N-ジメチル-1-プロパンアミン·塩酸塩;ドキセピン塩酸塩 (異性体混合物);11-(3-ジメチルアミノプロピリデン)-6,11-ジヒドロジベンゾ[b,e]オキセピン塩酸塩 (異性体混合物);ドキセピン塩酸塩(異性体混合物);ドキセピン 塩酸塩;塩酸ドキセピン
英語化学名:
Doxepin hydrochloride
英語别名:
DOXEPIN HCL;Sinequan;p-4599;adapin;Toruan;Novoxapin;TIMTEC-BB SBB005916;Doxepin Hydrochlorid;Doxopin hydrochloride;DOXEPIN HYDROCHLORIDE
CBNumber:
CB0334620
化学式:
C19H22ClNO
分子量:
315.84
MOL File:
1229-29-4.mol

ドキセピン塩酸塩(異性体混合物) 物理性質

融点 :
187-189°C
闪点 :
9℃
貯蔵温度 :
2-8°C
溶解性:
1 M HCl: 50 mg/mL
外見 :
powder
色:
white to off-white
水溶解度 :
Soluble in water (100 mM), chloroform (1:2), alcohol (1:1), methanol, and DMSO.
極大吸収波長 (λmax):
298nm(lit.)
Merck :
14,3435
安定性::
Store in Freezer at -20°C
InChIKey:
MHNSPTUQQIYJOT-SJDTYFKWSA-N
CAS データベース:
1229-29-4(CAS DataBase Reference)
安全性情報
  • リスクと安全性に関する声明
  • 危険有害性情報のコード(GHS)
主な危険性  T,F
Rフレーズ  25-39/23/24/25-23/24/25-11
Sフレーズ  36/37/39-45-36/37-16
RIDADR  UN 2811 6.1/PG 3
WGK Germany  3
RTECS 番号 HQ4375000
国連危険物分類  6.1(b)
容器等級  III
HSコード  29329990
毒性 LD50 oral in rat: 147mg/kg
絵表示(GHS)
注意喚起語 Danger
危険有害性情報
コード 危険有害性情報 危険有害性クラス 区分 注意喚起語 シンボル P コード
H301 飲み込むと有毒 急性毒性、経口 3 危険 P264, P270, P301+P310, P321, P330,P405, P501
注意書き

ドキセピン塩酸塩(異性体混合物) 価格 もっと(30)

メーカー 製品番号 製品説明 CAS番号 包装 価格 更新時間 購入
富士フイルム和光純薬株式会社(wako) W01COBQA-8049
Doxepin HCl
1229-29-4 1g ¥9000 2021-03-23 購入
富士フイルム和光純薬株式会社(wako) W01COBQA-8049
Doxepin HCl
1229-29-4 5g ¥23400 2021-03-23 購入
東京化成工業 D4626 ドキセピン塩酸塩 (異性体混合物) >98.0%(HPLC)(T)
Doxepin Hydrochloride (mixture of isomers) >98.0%(HPLC)(T)
1229-29-4 1g ¥4700 2022-04-26 購入
東京化成工業 D4626 ドキセピン塩酸塩 (異性体混合物) >98.0%(HPLC)(T)
Doxepin Hydrochloride (mixture of isomers) >98.0%(HPLC)(T)
1229-29-4 5g ¥13900 2022-04-26 購入
Sigma-Aldrich Japan Y0000851 European Pharmacopoeia (EP) Reference Standard
Doxepin hydrochloride European Pharmacopoeia (EP) Reference Standard
1229-29-4 ¥35200 2021-03-23 購入

ドキセピン塩酸塩(異性体混合物) 化学特性,用途語,生産方法

外観

白色〜ほとんど白色, 結晶〜粉末

溶解性

水に溶ける。

用途

三環系抗うつ作用化合物です。 モノアミン神経伝達物質再取り込み阻害作用 を示します。

用途

三環系抗うつ作用化合物です。 モノアミン神経伝達物質再取り込み阻害作用 を示します。

効能

抗うつ薬, ヒスタミン受容体拮抗薬, セロトニン・ノルアドレナリン再取り込み阻害薬

説明

Doxepin is a tricyclic antidepressant that binds to the serotonin (5-HT) transporter (SERT) and norepinephrine transporter (NET; Kds = 68 and 29.5 nM, respectively). It is a histamine H1 receptor antagonist (Ki = 1.23 nM). Doxepin selectively binds to SERT and NET over the dopamine transporter (DAT; Kd = 12,100 nM) and inhibits histamine H1 over H2, H3, and H4 receptors (Kis = 170, 39,810, and 15,135 nM, respectively). It also binds to the 5-HT2 receptor, as well as to muscarinic acetylcholine and α1-adrenergic receptors (α1-ARs; Kds = 27, 23, and 23.5 nM, respectively). Doxepin (10 mg/kg, i.p.) decreases allodynia and hyperalgesia in a mouse model of chronic constriction injury-induced neuropathic pain. It increases the distance traveled in the center of the open field test and reduces immobility time in the forced swim test in a mouse model of depression induced by chronic stress when administered orally at a dose of 15 mg/kg. Formulations containing doxepin have been used in the treatment of depression and insomnia.

化学的特性

White Solid

使用

Doxepin hydrochloride is a tricyclic antidepressant that inhibits the reuptake of serotonin and norepinephrine and acts as an antagonist at histamine, serotonin, adrenergic, and muscarinic receptors with Ki values in the nanomolar range.It is a antidepressant used clinically to treat anxiety and depression.

適応症

Doxepin (Sinequan, Adapin) is a tricyclic antidepressant with potent H1 and H2 antagonistic effects. It also has antimuscarinic, antiserotonic, and anti-α-adrenergic activity. Use of 10 to 50 mg PO t.i.d. to q.i.d. has been shown to be effective in the treatment of primary acquired, chronic idiopathic urticaria, idiopathic cold urticaria, and for patients with anxiety or depression associated with their urticaria. Sedation and dry mouth are the most common side effects. Doxepin may interact with other drugs that are metabolized by the cytochrome P-450 system (ketoconazole, itraconazole, erythromycin, clarithromycin, etc.).

一般的な説明

Doxepin, 3-dibenz[b,e]-oxepin-11(6H)ylidine-N,N-dimethyl-1-propanamine hydrochloride, N,N-dimethyl-3-(dibenz[b,e]oxepin-11(6H)-ylidene)propylamine (Sinequan, Adapin), isan oxa congener of amitriptyline, as can be seen from itsstructure.
The oxygen is interestingly placed and should influenceoxidative metabolism as well as postsynaptic and presynapticbinding affinities. The (Z)-isomer is the more active, althoughthe drug is marketed as the mixture of isomers. Thedrug overall is a NE and 5-HT reuptake blocker with significantanticholinergic and sedative properties. It can be anticipatedthat the nor- or des- metabolite will contribute to theoverall activity pattern.

ドキセピン塩酸塩(異性体混合物) 上流と下流の製品情報

原材料

準備製品


ドキセピン塩酸塩(異性体混合物) 生産企業

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1229-29-4(ドキセピン塩酸塩(異性体混合物))キーワード:


  • 1229-29-4
  • 11[16H]-[3-(DIMETHYLAMINO)-PROPYLIDENE]DIBENZ[B,E]OXEPINE HYDROCHLORIDE
  • 11-(3-dimethylaminopropylidene)-6,11-dihydro-benz[b,e]oxepin
  • 11-(3-DIMETHYLAMINOPROPYLIDENE)-6,11-DIHYDRODIBENZ[B,E]OXEPIN HYDROCHLORIDE
  • Doxepine hydrochloride
  • 1-Propanamine, 3-dibenzb,eoxepin-11(6H)-ylidene-N,N-dimethyl-, hydrochloride
  • DOXEPINHYDROCHLORIDE,USP
  • 11-(3-Dimethylaminopropylidene)-6,11-dihydrodibenz[b,e]oxepine hydrochloride
  • 3-DIBENZ(B,C)OXEPIN 11(6H)YLIDENE-N,N-DIMETHYL-1-PROPANAMINE HYDROCHLORIDE
  • e)oxepin-delta(sup11(6h),gamma)-propylamine,n,n-dimethyl-dibenz(hydrochlo
  • n,n-dimethyldibenz(b,e)oxepin-delta(sup11(6h),gamma)-propylaminehydrochlori
  • p-4599
  • 11-(3-dimethylaminopropylidene)-6,11-dihydro-benz[b,e]oxepin hcl
  • 3-(6,11-dihydrodibenz(b,e)oxepin-11-ylidene)propyldimethylamine hcl
  • Doxopin hydrochloride
  • DOXEPIN HYDROCHLORIDE
  • 11-dimethylaminopropylidene6h-dibenz(b,e)oxepin
  • 3-dibenz(b,e)oxepin-11(6h)ylidene-n,n-dimethyl-1-propanaminhydrochloride
  • 3-dibez[b,e]oxepin-11(6h)-ylidene-n,n-dimethyl-1-propanaminhydrochloride
  • adapin
  • cidoxepinhydrochloride
  • TIMTEC-BB SBB005916
  • Doxepin hydrochloride,11-(3-Dimethylaminopropylidene)-6,11-dihydrodibenz[b,e]oxepine hydrochloride
  • Doxepin Hydrochloride (500 mg)
  • Doxepin Hydrochlorid
  • Doxepin hydrochloride IMP
  • Doxepin hydrochloride solution
  • (E)-3-(dibenzo[b,e]oxepin-11(6H)-ylidene)-N,N-dimethylpropan-1-amine hydrochloride
  • Doxepin hydrochloride (mixture of isomers)
  • Doxepin Hydrochloride >
  • Doxepin HCl (Mixture of Z and E Isomer)
  • ドキセピン塩酸塩
  • 3-[ジベンゾ[b,e]オキセピン-11(6H)-イリデン]-N,N-ジメチル-1-プロパンアミン·塩酸塩
  • ドキセピン塩酸塩 (異性体混合物)
  • 11-(3-ジメチルアミノプロピリデン)-6,11-ジヒドロジベンゾ[b,e]オキセピン塩酸塩 (異性体混合物)
  • ドキセピン塩酸塩(異性体混合物)
  • ドキセピン 塩酸塩
  • 塩酸ドキセピン
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