Chinese english Germany Korea

MOZ-IN-3

化学構造式
2055397-18-5
CAS番号.
2055397-18-5
化学名:
别名:
英語名:
MOZ-IN-3
英語别名:
MOZ-IN-3;KAT6B inhibitor;KAT6A inhibitor;MOZ-IN-3/WM-8014;WM-8014;WM 8014;WM8014;KAT6A INHIBITOR; KAT6B INHIBITOR;N’-(4-Fluoro-5-methylbiphenyl-3-carbonyl)benzenesulfonohydrazide;N'-(4-Fluoro-5-methyl-[1,1'-biphenyl]-3-carbonyl)benzenesulfonohydrazide;WM-8014,HAT,inhibit,Inhibitor,HATs,WM 8014,Histone Acetyltransferase,WM8014;1,1'-Biphenyl]-3-carboxylic acid, 4-fluoro-5-methyl-, 3-(phenylsulfonyl)hydrazide;[1,1'-Biphenyl]-3-carboxylic acid, 4-fluoro-5-methyl-, 2-(phenylsulfonyl)hydrazide
CBNumber:
CB03376843
化学式:
C20H17FN2O3S
分子量:
384.42
MOL File:
2055397-18-5.mol

MOZ-IN-3 物理性質

比重(密度) :
1.307±0.06 g/cm3(Predicted)
貯蔵温度 :
Store at -20°C
溶解性:
DMF: 50 mg/ml; DMF:PBS (pH 7.2) (1:7): 0.1 mg/ml; DMSO: 33 mg/ml; Ethanol: 2 mg/ml
外見 :
A crystalline solid
酸解離定数(Pka):
7.15±0.25(Predicted)

安全性情報

MOZ-IN-3 価格

メーカー 製品番号 製品説明 CAS番号 包装 価格 更新時間 購入

MOZ-IN-3 化学特性,用途語,生産方法

説明

MOZ-IN-3 is an inhibitor of lysine acetyltransferase 6A (KAT6A/MOZ) and KAT6B/MORF (IC50s = 8 and 28 nM, respectively). It is selective for KAT6A and KAT6B over KAT5 and KAT7 (IC50s = 224 and 342 nM, respectively). MOZ-IN-3 induces cell cycle arrest in and inhibits proliferation of mouse embryonic fibroblasts (IC50 = 2.4 μM) and inhibits proliferation of EMRK1184 lymphoma cells (IC50 = 2.3 μM). It induces genetic and morphological changes associated with cellular senescence without inducing DNA damage, apoptosis, or necrosis. MOZ-IN-3 (10 μM) decreases global levels of acetylated histone H3 lysine 14 (H3K14Ac) by 49% and reduces H3K9Ac levels at the transcription start sites of Ezh2, Melk, and E2f2.

使用

MOZ-IN-3 is a highly potent and selective inhibitor of lysine acetyltransferases, KAT6A and KAT6B.

MOZ-IN-3 上流と下流の製品情報

原材料

準備製品

MOZ-IN-3 生産企業

Global( 51)Suppliers
名前 電話番号 電子メール 国籍 製品カタログ 優位度
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795
ivan@atkchemical.com China 32480 60
SHANGHAI T&W PHARMACEUTICAL CO., LTD. 		+86-021-61551413 +8618813727289
 contact@trustwe.com China 5738 58
InvivoChem 		+1-708-310-1919 +1-13798911105
 sales@invivochem.cn United States 6393 58
TargetMol Chemicals Inc. 		+1-781-999-5354
support@targetmol.com United States 19973 58
Aladdin Scientific 		+1-833-552-7181
sales@aladdinsci.com United States 57511 58
Amadis Chemical Company Limited 		571-89925085
sales@amadischem.com China 131981 58
Shanghai Lollane Biological Technology Co.,Ltd. 021-52996696，15000506266 15000506266
 China 4121 55
Tianjin Kailiqi Biotechnology Co., Ltd. 15076683720
 klq@cw-bio.com China 3444 55
ShangHai Biochempartner Co.,Ltd 17754423994 17754423994
 2853530910@QQ.com China 8011 62
Shanghai Rechem science Co., Ltd. 21-31433387 15618786686
 sales@rechemscience.com China 2982 58
  • 2055397-18-5
  • MOZ-IN-3
  • [1,1'-Biphenyl]-3-carboxylic acid, 4-fluoro-5-methyl-, 2-(phenylsulfonyl)hydrazide
  • MOZ-IN-3/WM-8014
  • WM-8014;WM 8014;WM8014;KAT6A INHIBITOR; KAT6B INHIBITOR
  • KAT6B inhibitor
  • KAT6A inhibitor
  • 1,1'-Biphenyl]-3-carboxylic acid, 4-fluoro-5-methyl-, 3-(phenylsulfonyl)hydrazide
  • WM-8014,HAT,inhibit,Inhibitor,HATs,WM 8014,Histone Acetyltransferase,WM8014
  • N’-(4-Fluoro-5-methylbiphenyl-3-carbonyl)benzenesulfonohydrazide
  • N'-(4-Fluoro-5-methyl-[1,1'-biphenyl]-3-carbonyl)benzenesulfonohydrazide
Copyright 2017 © ChemicalBook. All rights reserved