バルガンシクロビル塩酸塩
バルガンシクロビル塩酸塩 物理性質
- 融点 :
- 162-164°C
- 貯蔵温度 :
- Keep in dark place,Inert atmosphere,2-8°C
- 溶解性:
- H2O: ≥8mg/mL
- 外見 :
- 粉
- 色:
- 白から黄褐色
- 安定性：:
- 吸湿性
- InChIKey:
- ZORWARFPXPVJLW-MTFPJWTKSA-N
- CAS データベース:
- 175865-59-5
安全性情報
- リスクと安全性に関する声明
- 危険有害性情報のコード(GHS)
| WGK Germany |
3 |
|
|
| HSコード |
2933595960 |
|
|
| 絵表示（GHS） |
|
| 注意喚起語 |
警告 |
| 危険有害性情報 |
| コード |
危険有害性情報 |
危険有害性クラス |
区分 |
注意喚起語 |
シンボル |
P コード |
| H302 |
飲み込むと有害 |
急性毒性、経口 |
4 |
警告 |
|
P264, P270, P301+P312, P330, P501 |
| H312 |
皮膚に接触すると有害 |
急性毒性、経皮 |
4 |
警告 |
|
P280,P302+P352, P312, P322, P363,P501 |
| H332 |
吸入すると有害 |
急性毒性、吸入 |
4 |
警告 |
|
P261, P271, P304+P340, P312 |
|
| 注意書き |
| P261 |
粉じん/煙/ガス/ミスト/蒸気/スプレーの吸入を避ける こと。 |
| P264 |
取扱い後は皮膚をよく洗うこと。 |
| P264 |
取扱い後は手や顔をよく洗うこと。 |
| P270 |
この製品を使用する時に、飲食または喫煙をしないこ と。 |
| P271 |
屋外または換気の良い場所でのみ使用すること。 |
| P280 |
保護手袋/保護衣/保護眼鏡/保護面を着用するこ と。 |
| P301+P312 |
飲み込んだ場合：気分が悪い時は医師に連絡する こと。 |
| P302+P352 |
皮膚に付着した場合：多量の水と石鹸で洗うこと。 |
| P304+P340 |
吸入した場合：空気の新鮮な場所に移し、呼吸しやすい 姿勢で休息させること。 |
| P330 |
口をすすぐこと。 |
| P363 |
汚染された衣類を再使用す場合には洗濯をすること。 |
| P501 |
内容物/容器を．．．に廃棄すること。 |
|
バルガンシクロビル塩酸塩 価格
もっと(5)
| メーカー |
製品番号 |
製品説明 |
CAS番号 |
包装 |
価格 |
更新時間 |
購入 |
|
東京化成工業
|
V0158 |
バルガンシクロビル塩酸塩 >98.0%(T)
Valganciclovir Hydrochloride
>98.0%(T) |
175865-59-5 |
250mg |
￥7200 |
2023-06-01 |
購入 |
|
東京化成工業
|
V0158 |
バルガンシクロビル塩酸塩 >98.0%(T)
Valganciclovir Hydrochloride
>98.0%(T) |
175865-59-5 |
1g |
￥22500 |
2023-06-01 |
購入 |
|
Sigma-Aldrich Japan
|
PHR1626 |
バルガンシクロビル塩酸塩 Pharmaceutical Secondary Standard; Certified Reference Material
Valganciclovir Hydrochloride Pharmaceutical Secondary Standard; Certified Reference Material |
175865-59-5 |
1g |
￥33100 |
2024-03-01 |
購入 |
|
Sigma-Aldrich Japan
|
SML0191 |
≥98% (HPLC)
Valganciclovir hydrochloride hydrate ≥98% (HPLC) |
175865-59-5 |
10mg |
￥21800 |
2018-12-25 |
購入 |
|
Sigma-Aldrich Japan
|
SML0191 |
≥98% (HPLC)
Valganciclovir hydrochloride hydrate ≥98% (HPLC) |
175865-59-5 |
50mg |
￥84000 |
2024-03-01 |
購入 |
バルガンシクロビル塩酸塩 化学特性,用途語,生産方法
外観
白色～ほとんど白色粉末～結晶
効能
抗ウイルス薬, DNAポリメラーゼ阻害薬
商品名
バリキサ (田辺三菱製薬)
説明
Valganciclovir hydrochloride, a prodrug of the antiviral ganciclovir, was launched in the
US for the oral treatment of cytemegalovirus (CMV) retinitis, a sight-threatening
complication in patients with AIDS. This L-Valyl ester prodrug can be prepared in three
steps from the nucleoside analog ganciclovir by trimethylsilyl-protection of the amino
group, coupling with N-benzyloxycarbonyl-L-valine-N-carboxyanhydride, hydrolysis with
hydrochloric acid and hydrogenolysis of the Cbz-protecting group. Valganciclovir is well
absorbed and rapidly hydrolyzed to ganciclovir by intracellular esterases in the intestinal
mucosal cells and by hepatic esterases. Unlike ganciclovir, valganciclovir was
demonstrated to be actively transported by the intestinal peptide transporter PEPT1 in
Caco-2 cells. As a consequence, its absolute bioavailability in human was 10-fold higher
compared to ganciclovir (6%). In clinical trials, it was shown that a twice-daily 900 mg dose
of valganciclovir resulted in similar systemic ganciclovir exposure to 5 mg/kg twice-daily
intravenous injection of ganciclovir. Valganciclovir concentrations could not be quantified in
most patients within three to four hours. In a randomized non-blind phase III clinical trial,
oral valganciclovir (900 mg twice daily for three weeks then 900 mg once daily for one
week) was as effective as intravenous ganciclovir (5 mg/kg twice daily for three weeks
then 5 mg/kg once daily). Oral treatment with valganciclovir avoided catheter-related
infection that sometimes occurred with intravenous ganciclovir.
化学的特性
White Crystalline Solid
使用
Valganciclovir hydrochloride hydrate may be used in HIV-related cell signaling studies.
一般的な説明
Valganciclovir Hydrochloride is the L-valyl ester of ganciclovir and an antiviral drug, widely used to treat cytomegalovirus infections.
Certified pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to pharmacopeia primary standards.
バルガンシクロビル塩酸塩 上流と下流の製品情報
原材料
準備製品
バルガンシクロビル塩酸塩 生産企業
Global( 372)Suppliers
バルガンシクロビル塩酸塩 スペクトルデータ(1HNMR)
175865-59-5(バルガンシクロビル塩酸塩)キーワード:
- 175865-59-5
- L-Valine,2-[(2-aMino-1,6-dihydro-6-oxo-9H-purin-9-yl)Methoxy]-3-hydroxypropyl ester,hydrochloride (1:1)
- 2-[(2-amino-6-oxo-6,9-dihydro-3H-purin-9-yl)methoxy]-3-hydroxypropyl (2S)-2-amino-3-methylbutanoate hydrochloride hydrate
- L-Valine, 2-[(2-amino-1,6-dihydro-6-oxo-9H-purin-9-yl)methoxy]-3-hydroxypropyl ester, monohydrochloride hydrate
- Valganciclovir hydrochloride hydrate
- Rs 079070-194
- Unii-4p3T9qf9nz
- Valcyt
- Valganciclovir hydrochlorid
- Valganciclovir Hydrochloride (500 mg)
- 2-[(2-AMino-1,6-dihydro-6-oxo-9H-purin-9-yl)Methoxy]-3-hydroxypropyl Ester
- 25MG/100MG/1KG
- 5-Amino-3-[1-(hydroxymethyl)-2-(L-valyloxy)ethoxymethyl]-6,7- dihydro-3H-imidazo[4,5-d]pyrimidin-7-one hydrochloride
- L-Valine,2-[(2-amino-1,6-dihydro-6-oxo-9H-purin-9-yl)methoxy]-3-hydroxypropyl ester, hydrochloride
- VALGANCICLOVIR HYDROCHLORIDE
- L-VALINE, 2-[(2-AMINO-1,6-DIHYDRO-6-OXO-9H-PURIN-9-YL)METHOXY]-3-HYDROXYPROPYL ESTER, MONOHYDROCHLORIDE
- L-VALINE,2-[(2-AMINO-1,6-DIHYDRO-6-OXO-9H-PURIN-9-YL)METHOXY]-3-HYDROXYPROPYLESTER,MONOHYDROCHLORIDE
- Ro 107-9070/194
- 2-((2-Amino-6-oxo-1,6-dihydro-9H-purin-9-yl)methoxy)-3-hydroxypropyl L-valinate hydrochloride
- Valgancyclovir hydrochloride
- Valganciclovir-d5 HCl (Mixture of Diastereomers)
- Valganciclovir hydrochloric acid
- Valganciclovir HCl (Mixture of Diastereomers)
- Valganciclovir hydrochloride USP/EP/BP
- Valganciclovir hydrochloride (API)
- Valganciclovir D5 hydrochlorideQ: What is
Valganciclovir D5 hydrochloride Q: What is the CAS Number of
Valganciclovir D5 hydrochloride Q: What is the storage condition of
Valganciclovir D5 hydrochloride Q: What are the applications of
Valganciclovir D5 hydrochloride
- ValganciclovirHydrochlorideQ: What is
ValganciclovirHydrochloride Q: What is the CAS Number of
ValganciclovirHydrochloride Q: What is the storage condition of
ValganciclovirHydrochloride Q: What are the applications of
ValganciclovirHydrochloride
- Valganciclovir Hydrochloride (1708004)
- (2S)-2-((2-Amino-6-oxo-1H-purin-9(6H)-yl)methoxy)-3-hydroxypropyl 2-amino-3-methylbutanoate hydrochloride
- Valcyte
- VALGANCICLOVIR HCL
- バルガンシクロビル塩酸塩
- バルガンシクロビル塩酸塩 (JAN)