PF-06761281
PF-06761281 物理性質
- 沸点 :
- 469.7±45.0 °C(Predicted)
- 比重(密度) :
- 1.358±0.06 g/cm3(Predicted)
- 貯蔵温度 :
- -20°C
- 酸解離定数(Pka):
- 3.37±0.28(Predicted)
- 外見 :
- 粉
- 色:
- 白からベージュ
安全性情報
- リスクと安全性に関する声明
- 危険有害性情報のコード(GHS)
| RIDADR |
UN 2811 6.1 / PGIII |
|
|
| 絵表示（GHS） |
|
| 注意喚起語 |
危険 |
| 危険有害性情報 |
| コード |
危険有害性情報 |
危険有害性クラス |
区分 |
注意喚起語 |
シンボル |
P コード |
| H301 |
飲み込むと有毒 |
急性毒性、経口 |
3 |
危険 |
|
P264, P270, P301+P310, P321, P330,P405, P501 |
|
| 注意書き |
|
PF-06761281 価格
もっと(2)
| メーカー |
製品番号 |
製品説明 |
CAS番号 |
包装 |
価格 |
更新時間 |
購入 |
|
Sigma-Aldrich Japan
|
PZ0318 |
≥97% (HPLC)
PF-06761281 ≥97% (HPLC) |
1854061-19-0 |
5mg |
￥22400 |
2024-03-01 |
購入 |
|
Sigma-Aldrich Japan
|
PZ0318 |
≥97% (HPLC)
PF-06761281 ≥97% (HPLC) |
1854061-19-0 |
25mg |
￥72000 |
2024-03-01 |
購入 |
PF-06761281 化学特性,用途語,生産方法
使用
PF-06761281 has been used as a SLC13A family inhibitor, in rats to determine its unbound partition coefficient (Kpuu), to estimate its potency as a drug.
一般的な説明
PF-06761281 is a small, polar dicarboxylate compound. Its structure is similar to citrate, which is the endogenous substrate of Na
+-citrate cotransporter (NaCT). It is a novel, potent inhibitor of SLC13a2/3/5 (solute channel) family, along with selectivity for NaCT.
Biochem/physiol Actions
PF-06761281 is an inhibitor of the sodium-coupled citrate transporter (NaCT or SLC13A5), which may be a target for tretment and prevention of metabolic disorders. The SLC13 transporters SLC13A2 (NaDC1), SLC13A3 (NaDC3), and SLC13A5 (NaCT) co-transport di- and tricarboxylates with multiple sodium ions into cells. PF-06761281 inhibits citrate uptake with an IC50 of 740 nM for NaCT in human hepatocytes. PF-06761281 has >25-fold in vitro selectivity for NaCT over NaDC1 and NaDC3 and was inactive in a selectivity panel of 65 targets.
PF-06761281 上流と下流の製品情報
原材料
準備製品
PF-06761281 生産企業
Global( 5)Suppliers
- 1854061-19-0
- PF-06761281
- PF-06761281 >=97% (HPLC)
- Butanedioic acid, 2-hydroxy-2-[2-(2-methoxy-5-methyl-3-pyridinyl)ethyl]-, (2R)-