エストロゲン 化学特性,用途語,生産方法
解説
エストロゲン，雌の動物に発情estrusを起こさせるものという意味で，一群の雌(女)性ホルモンをさし，発情ホルモン，卵胞ホルモン，濾胞ホルモンともよばれる。動物体内で分泌されるエストロゲンはすべてステロイドで，A環はフェノールである。分泌期のヒト卵胞中には，エストロンestrone，エストラジオール‐17β estradiol‐17β，エストリオールestriolが見いだされ，このうちエストラジオール‐17βが分泌量，生物活性ともに最も高い。
株式会社平凡社 世界大百科事典 第２版について 情報
用途
製剤として，更年期障害，月経困難，卵巣機能障害などの治療に用いられるが，現在では合成エストロゲンを使うのが一般的。
化学的特性
Almost white or brownish, amorphous powder.
安全性プロファイル
Suspected human
carcinogen producing tumors of the vascular
system and liver. Human reproductive
effects: changes in female fertility. When
heated to decomposition it emits toxic
fumes of NazO. See also indvidual
components.
職業ばく露
Conjugated estrogens are naturally occurring substances excreted in the urine of pregnant mares; piperazine estrone sulfate is not known to occur naturally. Conjugated estrogens are used to treat symptoms of the climacteric, vulvae dystrophies; female hypogonadism; and dysfunctional uterine bleeding. They also are used for treatment following: ovariectomy, for chemotherapy of mammary cancer and prostate carcinogema; and for prevention of postpartum breast engorgement. In addition, conjugated estrogens have been found in cosmetic preparations
輸送方法
UN3077 Environmentally hazardous substances, solid, n.o.s., Hazard class: 9; Labels: 9-Miscellaneous hazardous material, Technical Name Required. UN3249 Medicine, solid, toxic, n.o.s., Hazard Class: 6.1; Labels: 6.1-Poisonous materials. PGIII.
不和合性
Estrogens are Incompatible with oxidizers (chlorates, nitrates, peroxides, permanganates, perchlorates, chlorine, bromine, fluorine, etc.); contact may cause fires or explosions. Keep away from alkaline materials, strong bases, strong acids, oxoacids, epoxides, acid chlorides, and acid anhydrides.
廃棄物の処理
It is inappropriate and possibly dangerous to the environment to dispose of expired or waste drugs and pharmaceuticals by flushing them down the toilet or discarding them to the trash. Household quantities of expired or waste pharmaceuticals may be mixed with wet cat litter or coffee grounds, double-bagged in plastic, discard in trash. Larger quantities shall carefully take into consideration applicable DEA, EPA, and FDA regulations. If possible return the pharmaceutical to the manufacturer for proper disposal being careful to properly label and securely package the material. Alternatively, the waste pharmaceutical shall be labeled, securely packaged, and transported by a state licensed medical waste contractor to dispose by burial in a licensed hazardous or toxic waste landfill or incinerator
エストロゲン 上流と下流の製品情報
原材料
準備製品