4-(m-トリルアミノ)ピリジン-3-スルホンアミド
4-(m-トリルアミノ)ピリジン-3-スルホンアミド 物理性質
- 融点 :
- 162-164?C
- 沸点 :
- 475.8±55.0 °C(Predicted)
- 比重(密度) :
- 1.357±0.06 g/cm3(Predicted)
- 貯蔵温度 :
- Keep in dark place,Inert atmosphere,Room temperature
- 溶解性:
- DMSO(微量)、メタノール(微量)
- 酸解離定数(Pka):
- 9.53±0.60(Predicted)
- 色:
- ホワイトからオフホワイト
- BRN :
- 5438165
- InChIKey:
- ZXPCUGWAKUIOOF-UHFFFAOYSA-N
- CAS データベース:
- 72811-73-5(CAS DataBase Reference)
安全性情報
- リスクと安全性に関する声明
- 危険有害性情報のコード(GHS)
主な危険性 |
Xi |
|
|
Rフレーズ |
36 |
|
|
Sフレーズ |
26 |
|
|
HSコード |
2935909550 |
|
|
絵表示(GHS) |
|
注意喚起語 |
警告 |
危険有害性情報 |
コード |
危険有害性情報 |
危険有害性クラス |
区分 |
注意喚起語 |
シンボル |
P コード |
H319 |
強い眼刺激 |
眼に対する重篤な損傷性/眼刺激 性 |
2A |
警告 |
|
P264, P280, P305+P351+P338,P337+P313P |
|
注意書き |
P305+P351+P338 |
眼に入った場合:水で数分間注意深く洗うこと。次にコ ンタクトレンズを着用していて容易に外せる場合は外す こと。その後も洗浄を続けること。 |
|
4-(m-トリルアミノ)ピリジン-3-スルホンアミド 価格
もっと(17)
メーカー |
製品番号 |
製品説明 |
CAS番号 |
包装 |
価格 |
更新時間 |
購入 |
富士フイルム和光純薬株式会社(wako)
|
W01MAS115185 |
4-[(3-Methylphenyl)amino]pyridine-3-sulfonamide |
72811-73-5 |
500mg |
¥61200 |
2024-03-01 |
購入 |
富士フイルム和光純薬株式会社(wako)
|
W01COBQC-6566 |
4-(3'-メチルフェニル)アミノ-3-ピリジンスルホンアミド
4-(3'-Methylphenyl)amino-3-pyridinesulfonamide |
72811-73-5 |
1g |
¥12500 |
2024-03-01 |
購入 |
富士フイルム和光純薬株式会社(wako)
|
W01COBQC-6566 |
4-(3'-メチルフェニル)アミノ-3-ピリジンスルホンアミド
4-(3'-Methylphenyl)amino-3-pyridinesulfonamide |
72811-73-5 |
5g |
¥37500 |
2024-03-01 |
購入 |
富士フイルム和光純薬株式会社(wako)
|
W01COBQC-6566 |
4-(3'-Methylphenyl)amino-3-pyridinesulfonamide |
72811-73-5 |
250mg |
¥22500 |
2023-06-01 |
購入 |
富士フイルム和光純薬株式会社(wako)
|
W01COBQC-6566 |
4-(3'-Methylphenyl)amino-3-pyridinesulfonamide |
72811-73-5 |
10g |
¥103500 |
2023-06-01 |
購入 |
4-(m-トリルアミノ)ピリジン-3-スルホンアミド 化学特性,用途語,生産方法
外観
白色~ほとんど白色粉末~結晶
化学的特性
White to Off-White Solid
使用
Torasemide intermediate.
合成
4-(3'-Methylphenyl)amino-3-pyridinesulfonamide is prepared by the reaction of 4-Chloropyridine-3-sulfonamide hydrochloride and 3-Methylaniline. The specific synthesis steps are as follows:
EXAMPLE 1; Preparation of 4-(3-methylphenyl)aminopyridine-sulfonamide; 2L three-neck flask, equipped with a mechanical stirrer, thermometer and condenser, was charged with water (500 ml) and 4-chloro-3- pyridinesulfonamide hydrochloride (100g, 0.44 mol). To this suspension was added m-toluidine (49.2 ml, 0.46 mol) at room temperature. The reaction mixture was heated to 90°C for a minimum period of 3 h. The progress of the reaction was followed by HPLC. After completion, the mixture was cooled to room temperature. The pH of the reaction was then adjusted carefully to pH 7-8 with sat. NaHC03 (ca. 1.1 l). The product was precipitated out and isolated by vacuum filtration as beige solid (126.2 g wet weight). The product was then dissolved in MeOH (1.0 l) at room temperature and charged with Darco KB (25g). The solution was refluxed for 0.5 h and then filtered through a patch of celite to remove Darco KB, while still hot, and rinsed with hot MeOH (200 ML). The filtrate was then charged with water (1.2 l) and stirred for a minimum of 1 h at room temperature. The product, which had precipitated out, was isolated by vacuum filtration to obtain a solid 106.3 g (92percent wet weight =>99.8percent purity a/a). 1H NMR (d6-DMSO) ; 2.30 (s, 3H), 7.00-7. 15 (m. 5H), 7.32 (m, 1H), 7.75 (brs, 1.5H), 8.05 (brs, 0.5H), 8.25 (d, 1H), 8.68 (s, 1H).
4-(m-トリルアミノ)ピリジン-3-スルホンアミド 上流と下流の製品情報
原材料
準備製品
4-(m-トリルアミノ)ピリジン-3-スルホンアミド 生産企業
Global( 312)Suppliers
72811-73-5(4-(m-トリルアミノ)ピリジン-3-スルホンアミド)キーワード:
- 72811-73-5
- 4-(-3-METHYLPHENYL)AMINO-3-PYRIDINESULFONAMIDE
- 4-(3'-METHYLPHENYL)AMINO-3-PYRIDINESULFONAMIDE
- 3-SULFONAMIDO-4-(3-METHYLANILINO)-PYRIDINE
- SPECS AJ-333/25006115
- 4-(3-METHYLPHENYL)AMINO-3-PYRIDINESULFONAMIDE (SMPAP)
- 4-[3-Methyl phenyl] amino-3-pyridine sulphonamide
- Torasemide intermediate
- [4-(3-Methylphenyl)amino]pyrid
- 4-(3-methylphenyl)amino-3-pyridine sulfonamide (intermediate of torasemide)
- 4-(3-methylphenylamino) Pyridine-3-sulfonamide
- [4-3-Methylphenyl)amino]pyridine-3-sulphonamide
- 4-(3-METHYLPHENYL)AMINO-3-PYRIDINESULFONAMIDE 98%
- 4-(3'-Methylphenyl)a
- TorseMide Related CoMpound A
- BM 960102
- 4-(M-TolylaMino)pyridine-3-sulfonaMide
- TorseMide IMpurity B
- Standard for Torasemide Impurity
- Torasemide Impurity 2(Torasemide EP Impurity B)
- Torasemide EP Impurity B
- Torasemide impurity B (EP)
- 4-[(3-Methylphenyl)amino]-pyridin-3-sulfonamide
- Torsemide USP Related Compound A
- Torasemi Impurity B Standard
- 4[(3-Methyl Phenyl) amino] 3-Pyridine Sulfonamide (Torsamide Intermediate) (72811-73-5)
- 4-[(3-Methylphenyl)amino]pyridine-3
- 3-Pyridinesulfonamide, 4-[(3-methylphenyl)amino]-
- Torsemide EP Impurity B
- 4-(3-Methylphenyl)amino-3-sulfamoylpyridine
- 4-(m-Tolylamino)-3-sulfamoylpyridine
- 4-(m-トリルアミノ)ピリジン-3-スルホンアミド
- 4-(3-メチルフェニル)アミノ-3-スルファモイルピリジン
- 4-(3-メチルフェニル)アミノピリジン-3-スルホンアミド
- 4-(m-トリルアミノ)-3-スルファモイルピリジン
- 4-[(3-メチルフェニル)アミノ]-3-ピリジンスルホンアミド
- 4-(3'-メチルフェニル)アミノ-3-ピリジンスルホンアミド
- Torsemide Related Compound A (4-[(3-methylphenyl)amino]-3-pyridinesulfonamide)
- 4-[(3-メチルフェニル)アミノ]ピリジン-3-スルホンアミド
- 4-(3-メチルフェニルアミノ)ピリジン-3-スルホンアミド