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安息香酸ナトリウム

安息香酸ナトリウム 化学構造式
532-32-1
CAS番号.
532-32-1
化学名:
安息香酸ナトリウム
别名:
安息香酸ナトリウム;ナトリウムベンゾアート;安息香酸Na;安息香酸ソーダ;安息香酸ナトリウム [生化学用];ナトリウム=ベンゾアート;安息香酸ナトリウム(粉末);安息香酸ナトリウム塩;安息香酸ナトリウム(顆粒);安息香酸ナトリウム, 99%;安息香酸ナトリウム (JP17)
英語化学名:
Sodium benzoate
英語别名:
ucephan;PUROX S;antimol;sobenate;FEMA 3025;BENZOTRON;BENZOTRON(R);benzoansodny;femanumber3025;odium benzoate
CBNumber:
CB0698779
化学式:
C7H5NaO2
分子量:
144.10317
MOL File:
532-32-1.mol

安息香酸ナトリウム 物理性質

融点 :
>300 °C (lit.)
比重(密度) :
1,44 g/cm3
FEMA :
3025 | SODIUM BENZOATE
闪点 :
>100°C
貯蔵温度 :
room temp
溶解性:
H2O: 1 M at 20 °C, clear, colorless
外見 :
Crystals, Granules, Flakes or Crystalline Powder
色:
White
PH:
7.0-8.5 (25℃, 1M in H2O)
水溶解度 :
soluble
Merck :
14,8582
BRN :
3572467
安定性::
Stable, but may be moisture senstive. Incompatible with strong oxidizing agents, alkalis, mineral acids.
InChIKey:
WXMKPNITSTVMEF-UHFFFAOYSA-M
CAS データベース:
532-32-1(CAS DataBase Reference)
NISTの化学物質情報:
Sodium benzoate(532-32-1)
EPAの化学物質情報:
Sodium benzoate (532-32-1)
安全性情報
  • リスクと安全性に関する声明
  • 危険有害性情報のコード(GHS)
主な危険性  Xi
Rフレーズ  36/37/38-62-63-68-36
Sフレーズ  24/25-36-26
WGK Germany  1
RTECS 番号 DH6650000
TSCA  Yes
HSコード  29163100
有毒物質データの 532-32-1(Hazardous Substances Data)
毒性 LD50 orally in rats: 4.07 g/kg (Smyth, Carpenter)
化審法 (3)-1272, (3)-1293
絵表示(GHS)
注意喚起語 Warning
危険有害性情報
コード 危険有害性情報 危険有害性クラス 区分 注意喚起語 シンボル P コード
H303 飲み込むと有害のおそれ 急性毒性、経口 5 P312
H315 皮膚刺激 皮膚腐食性/刺激性 2 警告 P264, P280, P302+P352, P321,P332+P313, P362
H319 強い眼刺激 眼に対する重篤な損傷性/眼刺激 性 2A 警告 P264, P280, P305+P351+P338,P337+P313P
注意書き
P264 取扱い後は皮膚をよく洗うこと。
P264 取扱い後は手や顔をよく洗うこと。
P305+P351+P338 眼に入った場合:水で数分間注意深く洗うこと。次にコ ンタクトレンズを着用していて容易に外せる場合は外す こと。その後も洗浄を続けること。
P321 特別な処置が必要である(このラベルの... を見よ)。
P332+P313 皮膚刺激が生じた場合:医師の診断/手当てを受けるこ と。
P337+P313 眼の刺激が続く場合:医師の診断/手当てを受けること。

安息香酸ナトリウム 価格 もっと(47)

メーカー 製品番号 製品説明 CAS番号 包装 価格 更新時間 購入
富士フイルム和光純薬株式会社(wako) W01ACSAP-002N 安息香酸ナトリウム
Sodium benzoate
532-32-1 1g ¥3700 2021-03-23 購入
富士フイルム和光純薬株式会社(wako) W01CHDASB-00002067 安息香酸ナトリウム塩
Benzoic Acid Sodium Salt
532-32-1 100mg ¥10100 2018-12-26 購入
東京化成工業 S0593 安息香酸ナトリウム >98.0%(HPLC)(T)
Sodium Benzoate >98.0%(HPLC)(T)
532-32-1 25g ¥1700 2021-03-23 購入
東京化成工業 S0593 安息香酸ナトリウム >98.0%(HPLC)(T)
Sodium Benzoate >98.0%(HPLC)(T)
532-32-1 500g ¥3500 2021-03-23 購入
関東化学株式会社(KANTO) 37114-01 安息香酸ナトリウム >95.0%(T)
Sodium benzoate >95.0%(T)
532-32-1 500g ¥4600 2021-03-23 購入

安息香酸ナトリウム MSDS


Sodium benzoate

安息香酸ナトリウム 化学特性,用途語,生産方法

外観

白色の結晶性の粉末又は粒

定義

本品は、安息香酸(*)のナトリウム塩であり、次の化学式で表される。
参照表示名称:安息香酸

溶解性

無色澄明 (1.0g, 水5mL)

用途

清涼飲料、しょう油

化粧品の成分用途

防腐剤、腐蝕防止剤、香料

効能

高アンモニア血症治療薬, 防腐剤

主な用途/役割

有機系結晶核剤、カルボン酸金属塩タイプ、PP用

商品名

安息香酸ナトリウム (丸石製薬); 安息香酸ナトリウム (小堺製薬)

説明

Sodium benzoate has the chemical formula NaC7H5O2; it is a widely used food preservative, with E number E211. It is the sodium salt of benzoic acid and exists in this form when dissolved in water. It can be produced by reacting sodium hydroxide with benzoic acid.

化学的特性

Benzoic acid is almost odorless or exhibits a sweet, faint, balsamic odor and a sweet–sour to acrid taste. For a detailed description, refer to Burdock (1997).

化学的特性

Sodium benzoate occurs as a white granular or crystalline, slightly hygroscopic powder. It is odorless, or with faint odor of benzoin and has an unpleasant sweet and saline taste.

化学的特性

white crystalline powder

化学的特性

Sodium benzoate is a white crystalline solid. It is odorless and nonflammable

天然物の起源

Benzoic acid occurs naturally in many plants and in animals. The salt is not found to occur naturally.

使用

Sodium benzoate is a preservative. It is bacteriostatic and fungistatic under acidic conditions. It is most widely used in acidic foods such as salad dressings (vinegar), carbonated drinks (carbonic acid), jams and fruit juices (citric acid), pickles (vinegar), and condiments. It is also used as a preservative in medicines and cosmetics. As a food additive, sodium benzoate has the E number E211.
It is also used in fireworks as a fuel in whistle mix, a powder that emits a whistling noise when compressed into a tube and ignited. The fuel is also one of the fastest burning rocket fuels and provides a lot of thrust and smoke. It does have its downsides: there is a high danger of explosion when the fuel is sharply compressed because of the fuel's sensitivity to impact.

使用

Sodium Benzoate is a preservative that is the sodium salt of benzoic acid. it converts to benzoic acid, which is the active form. it has a solubility in water of 50 g in 100 ml at 25°c. sodium benzoate is 180 times as soluble in water at 25°c as is the parent acid. the optimum functionality occurs between ph 2.5 and 4.0 and it is not recom- mended above ph 4.5. it is active against yeasts and bacteria. it is used in acidic foods such as fruit juices, jams, relishes, and bever- ages. its use level ranges from 0.03 to 0.10%.

使用

Antimicrobial agent, flavoring agent and adjuvant in food; not to exceed a maximum level of 0.1% in food (21 CFR, 184.1733, 582.3733). Antifungal and bacteriostatic preservative in pharmaceuticals at concentrations of ~0.1%. Clinical reagent (bilirubin assay).

使用

sodium benzoate is a non-toxic, organic salt preservative that is particularly effective against yeast, with some activity against molds and bacteria. It is generally used in concentrations of 0.1 to 0.2 percent.

使用

Vasodilator

使用

A benzene compound used as a synthetic reagent.

定義

ChEBI: An organic sodium salt resulting from the replacement of the proton from the carboxy group of benzoic acid by a sodium ion.

調製方法

Sodium benzoate is prepared by adding benzoic acid to a hot concentrated solution of sodium carbonate until effervescence ceases. The solution is then evaporated, cooled and allowed to crystallize or evaporate to dryness, and then granulated.

製造方法

Produced by the neutralization of benzoic acid with sodium bicarbonate, sodium carbonate or sodium hydroxide.

調製方法

Prepared by the treatment of benzoic acid with either sodium carbonate or sodium bicarbonate.

定義

sodium benzoate: An either colourlesscrystalline or white amorphouspowder, C6H5COONa, soluble inwater and slightly soluble in ethanol.It is made by the reaction of sodiumhydroxide with benzoic acid and isused in the dyestuffs industry and asa food preservative. It was formerlyused as an antiseptic.

危険性

Use in foods limited to 0.1%.

応用例(製薬)

Sodium benzoate is used primarily as an antimicrobial preservative in cosmetics, foods, and pharmaceuticals. It is used in concentrations of 0.02–0.5% in oral medicines, 0.5% in parenteral products, and 0.1–0.5% in cosmetics. The usefulness of sodium benzoate as a preservative is limited by its effectiveness over a narrow pH range.
Sodium benzoate is used in preference to benzoic acid in some circumstances, owing to its greater solubility. However, in some applications it may impart an unpleasant flavor to a product. Sodium benzoate has also been used as a tablet lubricant at 2–5% w/w concentrations. Solutions of sodium benzoate have also been administered, orally or intravenously, in order to determine liver function.

安全性プロファイル

Poison by subcutaneous and intravenous routes. Moderately toxic by ingestion, intramuscular, and intraperitoneal routes. An experimental teratogen. Experimental reproductive effects. Mutation data reported. Larger doses of 8-10 g by mouth may cause nausea and vomiting. Small doses have little or no effect. Combustible when exposed to heat or flame. When heated to decomposition it emits toxic fumes of Na2O. See also BENZOIC ACID.

安全性

Ingested sodium benzoate is conjugated with glycine in the liver to yield hippuric acid, which is excreted in the urine. Symptoms of systemic benzoate toxicity resemble those of salicylates. Whereas oral administration of the free-acid form may cause severe gastric irritation, benzoate salts are well tolerated in large quantities: e.g. 6 g of sodium benzoate in 200mL of water is administered orally as a liver function test.
Clinical data have indicated that sodium benzoate can produce nonimmunological contact urtcaria and nonimmunological immediate contact reactions. However, it is also recognized that these reactions are strictly cutaneous, and sodium benzoate can therefore be used safely at concentrations up to 5%. However, this nonimmunological phenomenon should be considered when designing formulations for infants and children.
Other adverse effects include anaphylaxis and urticarial reactions, although a controlled study has shown that the incidence of urticaria in patients given benzoic acid is no greater than that with a lactose placebo.
It has been recommended that caffeine and sodium benzoate injection should not be used in neonates; however, sodium benzoate has been used by others in the treatment of some neonatal metabolic disorders. It has been suggested that there is a general adverse effect of benzoate preservatives on the behavior of 3-yearold children, which is detectable by parents, but not by a simple clinical assessment.
The WHO acceptable daily intake of total benzoates, calculated as benzoic acid, has been estimated at up to 5 mg/kg of bodyweight.
LD50 (mouse, IM): 2.3 g/kg
LD50 (mouse, IV): 1.4 g/kg
LD50 (mouse, oral): 1.6 g/kg
LD50 (rabbit, oral): 2.0 g/kg
LD50 (rat, IV): 1.7 mg/kg
LD50 (rat, oral): 4.1 g/kg

安全性

In combination with ascorbic acid (vitamin C, E300), sodium benzoate and potassium benzoate form benzene, a known carcinogen. However, in most beverages that contain both, the benzene levels are below those considered dangerous for consumption. Heat, light and shelf life can affect the rate at which benzene is formed.

職業ばく露

Sodium benzoate is used as a food and feed additive, flavor, packaging material; pharmaceutical; preservative for food products and tobacco; anti-fungal agent; antiseptic, rust, and mildew inhibitor; intermediate in the manufacture of dyes. Used as a human hygiene biocidal product.

貯蔵

Aqueous solutions may be sterilized by autoclaving or filtration. The bulk material should be stored in a well-closed container, in a cool, dry place.

輸送方法

UN2811 Toxic solids, organic, n.o.s., Hazard Class: 6.1; Labels: 6.1-Poisonous materials, Technical Name Required.

Properties and Applications

TEST ITEMS

SPECIFICATION

APPEARANCE

WHITE POWDER

CONTENT OF SODIUM BENZOATE

99.0% min

DRY LOSS

0.10% max

pH VALUE

8

TOTAL CHLORIDE

300 ppm max

TRANSPARENCE

PASS

TOTAL HEAVY METAL

0.001% max

As CONTENT

0.0002% max

純化方法

Crystallise it from EtOH (12mL/g). [Beilstein 9 IV 27.]

Mechanism of food preservation

The mechanism starts with the absorption of benzoic acid into the cell. If the intracellular pH changes to 5 or lower, the anaerobic fermentation of glucose through phosphofructokinase is decreased by 95 %, thereby inhibiting the growth and survival of micro-organisms that cause food spoilage.

不和合性

Incompatible with quaternary compounds, gelatin, ferric salts, calcium salts, and salts of heavy metals, including silver, lead, and mercury. Preservative activity may be reduced by interactions with kaolin or nonionic surfactants.

不和合性

Dust may form explosive mixture with air. Incompatible with oxidizers (chlorates, nitrates, peroxides, permanganates, perchlorates, chlorine, bromine, fluorine, etc.); contact may cause fires or explosions. Keep away from alkaline materials, strong bases, strong acids, oxoacids, epoxides.

規制状況(Regulatory Status)

GRAS listed. Accepted as a food additive in Europe. Included in the FDA Inactive Ingredients Database (dental preparations; IM and IV injections; oral capsules, solutions and tablets; rectal; and topical preparations). Included in nonparenteral medicines licensed in the UK. Included in the Canadian List of Acceptable Non-medicinal Ingredients.

安息香酸ナトリウム 上流と下流の製品情報

原材料

準備製品


安息香酸ナトリウム 生産企業

Global( 668)Suppliers
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532-32-1(安息香酸ナトリウム)キーワード:


  • 532-32-1
  • SODIUM BENZOATE
  • PUROX S
  • femanumber3025
  • sobenate
  • sodiumbenzoate,medicinal
  • sodiumbenzoicacid
  • ucephan
  • BENZOTRON(R)
  • BENZOIC ACID SODIUM SALT
  • FEMA 3025
  • benzoic acid sodium crystalline
  • benzoic acid sodium sigmaultra
  • SODIUM BENZOATE BP 93
  • Sodium benzoate Food grad
  • SODIUM BENZOATE, REAGENTPLUS, 99%
  • Sodium benzoate,Benzoic acid sodium salt
  • Sodium benzoate, synthesis grade
  • Sodium Benzoate (1 g)
  • Cactus Plant Extract
  • SodiuM Benzoate [for BiocheMical Research]
  • SodiuM Benzoate Powder / Granule
  • Sodium Benzoate, fine powder
  • SodiuM Benzoate, Technical
  • SodiuM benzoate, 99%, for biocheMistry
  • SodiuM benzoate, 99+%, extra pure
  • MetronidazoledisodiuMhydrogenphosphate
  • Sodium Benzonate
  • Sodium benzoate puriss., meets analytical specification of Ph.Eur., BP, FCC, E211, 99.0-100.5% (calc. to the dried substance), powder
  • Sodium benzoate purum p.a., >=99.0% (NT)
  • Sodium benzoate ReagentPlus(R), 99%
  • 安息香酸ナトリウム
  • ナトリウムベンゾアート
  • 安息香酸Na
  • 安息香酸ソーダ
  • 安息香酸ナトリウム [生化学用]
  • ナトリウム=ベンゾアート
  • 安息香酸ナトリウム(粉末)
  • 安息香酸ナトリウム塩
  • 安息香酸ナトリウム(顆粒)
  • 安息香酸ナトリウム, 99%
  • 安息香酸ナトリウム (JP17)
  • 保存料
  • 抗真菌薬
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