アモバルビタール 化学特性,用途語,生産方法
解説
アミタール，アモバルビタールamobarbitalの商品名で，イソミタールIsomytal(商品名)も同一薬品である。白色の結晶または結晶性の粉末の催眠薬。化学的には5‐エチル‐5‐イソアミルバルビタール酸という。バルビタール酸が合成されたのが1864年で，バルビタールは1903年に合成されたが，アミタールが合成されたのは23年で，アメリカのリリー社により発売された。バルビタール酸系催眠薬のうちで中間持続型に属し，服用後約30分で催眠効果が表れ，4～6時間熟眠する。
効能
催眠鎮静薬
商品名
イソミタール (日本新薬)
化学的特性
Crystalline Solid
使用
Amobarbital for binding at complex I to inhibit mitochondrial electron transport. Amobarbital is regulated as a schedule II compound in the United States and intended only for forensic and research purposes. This product is a qualified Reference Material (RM) that has been manufactured and tested to meet ISO17025 and Guide 34 guidelines. These materials are tested using validated analytical methods on qualified instrumentation to ensure traceability of measurements. All traceable RMs may be distinguished by their CofAs and can be downloaded below using the batch number located on the product label. For a representative CofA please contact our technical support.
定義
ChEBI: A member of the class of barbiturates that is pyrimidine-2,4,6(1H,3H,5H)-trione substituted by a 3-methylbutyl and an ethyl group at position 5. Amobarbital has been shown to exhibit sedative and hy
notic properties.
世界保健機関（WHO）
Amobarbital is an intermediate-acting barbiturate which is
controlled under Schedule III of the 1971 Convention on Psychotropic Substances.
See WHO comment for barbiturates.
(Reference: (UNCPS3) United Nations Convention on Psychotropic Substances (III),
, , 1971)
一般的な説明
White crystalline solid with no odor and a slightly bitter taste.
空気と水の反応
Amobarbital is hygroscopic . Insoluble in water.
反応プロフィール
Amines are chemical bases. They neutralize acids to form salts plus water. These acid-base reactions are exothermic. The amount of heat that is evolved per mole of amine in a neutralization is largely independent of the strength of the amine as a base. Amines may be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Flammable gaseous hydrogen is generated by amines in combination with strong reducing agents, such as hydrides.
危険性
May be a habit forming drug of abuse.
火災危険
Flash point data for Amobarbital are not available, however, Amobarbital is probably combustible.
安全性プロファイル
A poison by ingestion,intravenous, intraperitoneal, and subcutaneous routes. Seealso BARBITURATES. When heated to decomposition itemits toxic fumes of NOx.
アモバルビタール 上流と下流の製品情報
原材料
準備製品