タイランスタチンA

タイランスタチンA 価格

メーカー	製品番号	製品説明	CAS番号	包装	価格	更新時間	購入

タイランスタチンA 化学特性,用途語,生産方法

説明

Thailanstatin A, a promising lead compound for drug discovery and development efforts, is derived from Thailandensis burkholderia MSMB43. It reveals low nanomolar to subnanomolar cytotoxicity against a variety of human cancer cell lines.

作用機序

The mechanism of action (MOA) of thailanstatin A is the inhibition of spliceosome assembly. Thailanstatin A binds firmly to the SF3b subunit of the U2 snRNA sub-complex, a crucial component of the spliceosome. Since the spliceosomes of cancer cells are more active and exhibits higher mutation rates than those of normal cells, this sub-cellular component is by far the most well-established anti-tumor target in novel drug discoveries.

合成

Thailanstatin A (1): To a stirred solution of epoxide 6 (4.0 mg, 0.012 mmol, 1.0 equiv) and boronate 5 (5.8 mg, 13 |ìmol, 1.1 equiv) in rigorously degassed (freeze-pump-thaw technique3) 3:1:1 1,4-dioxane/MeCN/H2O (0.64 mL,) at 25C. was added tripotassium phosphate monohydrate (2.8 mg, 0.012 mmol, 1.0 equiv) followed by Pd(dppf)Cl2.CH2Cl2 (0.1 mg, 0.125 |ìmol, 0.025 equiv). After 10 min, the reaction mixture was neutralized with phosphate buffer (NaH2PO4, 1.0 M, 2.5 mL), filtered through a layer of Celite, and rinsed thoroughly with ethyl acetate (20 mL). Then the organic layer was dried with anhydrous sodium sulfate and concentrated in vacuo. The obtained residue was purified by reversed-phase HPLC (C18, |19150 mm, Atlantis, 40ú50% aqueous MeCN containing 0.03% TFA) to afford thailanstatin A (1) (ca. 3.0 mg, 6.0 |ìmol, 52%) as a white foam.

タイランスタチンA 上流と下流の製品情報

原材料

準備製品

タイランスタチンA 生産企業

名前	電話番号	電子メール	国籍	製品カタログ	優位度
Zhejiang Huida Biotech Co., LTD	0571-89903022 18679456698	zilong@hizyme.com	China	8001	58
Chembest Research Laboratories Limited	021-20908456	sales@BioChemBest.com	China	5996	61
T&W GROUP	021-61551611 13296011611	contact@trustwe.com	China	9884	58
Nanjing Sunlida Biological Technology Co., Ltd.	025-57798810 18652991625	sales@sunlidabio.com	China	3223	55
Sichuan Wei Keqi Biological Technology Co., Ltd.	028-81700200 18116577057	3003855609@qq.com	China	7690	56
Taizhou KEDE Chemical Co., Ltd	0576-84613060 13093829633;13736603231;	sales@kedechemical.com	China	299	60
Shanghai EFE Biological Technology Co., Ltd.	021-65675885 18964387627	info@efebio.com	China	9799	58
Wellman Pharmaceutical Group Limited	15807197853 18971451745	15807197853@163.com	China	3981	58
Dideu Industries Group Limited	+86-29-89586680 +86-15129568250	1059@dideu.com	China	29086	58
Henan Alfa Chemical Co., Ltd	+8618339805032	sale03@alfachem.cn	China	9872	58

1426953-21-0(タイランスタチンA)キーワード:

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• 1426953-21-0
• 1,6-Dioxaspiro[2.5]octane-5-acetic acid, 7-[(1E,3E)-5-[(2S,3S,5R,6R)-5-[[(2Z,4S)-4-(acetyloxy)-1-oxo-2-penten-1-yl]amino]tetrahydro-3,6-dimethyl-2H-pyran-2-yl]-3-methyl-1,3-pentadien-1-yl]-8-hydroxy-, (3R,5S,7R,8R)-
• Thailandstatin A
• Thailanstatin A
• ADC Payload,natural,Inhibitor,inhibit,SF3b,subunit,antiproliferative,Thailanstatin A,spliceosome,ADC,ADC Cytotoxin,RNA,linker
• 6-dioxaspiro[2.5]oct-5-yl]acetic acid
• 2-[(3R,5S,7R,8R)-7-[(1E,3E)-5-[(2S,3S,5R,6R)-5-[(2Z,4S)-4-(acetyloxy)pent-2-enamido]-3,6-dimethyloxan-2-yl]-3-methylpenta-1,3-dien-1-yl]-8-hydroxy-1,6-dioxaspiro[2.5]octan-5-yl]acetic acid
• Terance Statin A
• タイランスタチンA
• (4S)-5α-ヒドロキシ-6β-(5-(3β,6β-ジメチルテトラヒドロ-5β-(1-オキソ-4-メチル-4-(1-オキソエチルオキシ)-2-ブテニルアミノ)-2H-ピラン-2β-イル)-3-メチル-1,3-ペンタジエニル)-4,4-(エポキシメタノ)テトラヒドロ-2H-ピラン2α-酢酸
• 2-[(3S,5S,7R,8R)-7-{5-[(2S,3S,5R,6R)-5-[4-(アセチルオキシ)ペンタ-2-エンアミド]-3,6-ジメチルオキサン-2-イル]-3-メチルペンタ-1,3-ジエン-1-イル}-8-ヒドロキシ-1,6-ジオキサスピロ[2.5]オクタン-5-イル]酢酸