テノホビルジソプロキシル

テノホビルジソプロキシル 価格

メーカー	製品番号	製品説明	CAS番号	包装	価格	更新時間	購入

テノホビルジソプロキシル 化学特性,用途語,生産方法

説明

Tenofovir disoproxil is a prodrug in a manner similar to that of adefovir dipivoxil. In both cases, the phosphate esters are removed through the action of plasma esterase, leading in this case to tenofovir, which differs from adefovir by the presence of the indicated methyl group. Tenofovir disoproxil exhibits good bioavailability (25%), which is improved in the presence of food (35%). The drug is approved for the treatment of HIV infections in adult patients. Tenofovir diphosphate is an HIV RT inhibitor. The active form of tenofovir is the tenofovir diphosphate, which competes with dATP for incorporation into viral DNA, and when incorporated, tenofovir diphosphate results in premature termination of DNA growth and inhibition of DNA polymerase. Tenofovir disoproxil is indicated for treatment-experienced patients with HIV-1. The drug also appears to be effective in treatment-naive patients, but initial approval is for treatment-experienced patients. The drug is administered as one tablet taken once daily. It is recommended that the drug be combined with other RT inhibitors or HIV PIs, which results in additive or synergistic activity.

使用

Tenofovir Disoproxil is a therapeutic option for nucleos(t)ide analog (NA)-experienced chronic hepatitis B (CHB) patients infected with hepatitis B virus (HBV). Also, it is an intermediate used in the synthesis of Tenofovir Disoproxil Dimer (T018515), which is a Tenofovir Disoproxil impurity.

定義

ChEBI: An organic phosphonate that is the disoproxil ester of tenofovir. A prodrug for tenofovir, an HIV-1 reverse transcriptase inhibitor, tenofovir disoproxil is used as the fumaric acid salt in combination therapy for the treatment of HIV infection.

一般的な説明

Tenofovir disoproxil is a prodrug analogously with abacavir.Plasma and tissue esterases cleave the phosphateprotecting groups, releasing the active drug. The bioavailabilityof tenofovir is about 35% when administered withfood. The drug is approved by the Food and DrugAdministration (FDA) for the treatment of HIV infectionsin adult patients. Recommendations are for the drug to beadministered with other RT inhibitors or PIs to achievesynergism.

テノホビルジソプロキシル 上流と下流の製品情報

原材料

準備製品

テノホビルジソプロキシル 生産企業

名前	電話番号	電子メール	国籍	製品カタログ	優位度
Hebei Mojin Biotechnology Co., Ltd	+8613288715578	sales@hbmojin.com	China	12457	58
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21695	55
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	32480	60
Anqing Chico Pharmaceutical Co., Ltd.	15380796838	chloewu@chicopharm.cn	CHINA	341	58
career henan chemical co	+86-0371-86658258	sales@coreychem.com	China	29914	58
Hebei Guanlang Biotechnology Co., Ltd.	+86-19930503282	alice@crovellbio.com	China	8823	58
Hubei xin bonus chemical co. LTD	86-13657291602	linda@hubeijusheng.com	CHINA	22968	58
Chongqing Chemdad Co., Ltd	+86-023-61398051 +8613650506873	sales@chemdad.com	China	39916	58
Alchem Pharmtech,Inc.	8485655694	sales@alchempharmtech.com	United States	63711	58
Shaanxi Dideu Medichem Co. Ltd	18192627656	1012@dideu.com	China	3453	58

201341-05-1(テノホビルジソプロキシル)キーワード:

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• 201341-05-1
• (R)-(((((1-(6-AMino-9H-purin-9-yl)propan-2-yl)oxy)Methyl)phosphoryl)bis(oxy))bis(Methylene) diisopropyl dicarbonate
• (R)-(((((1-(6-Amino-9H-purin-9-yl)propan-2-yl)oxy)methyl)phosphoryl)-bis(oxy))bis(methylene) diis
• 2,4,6,8-Tetraoxa-5-phosphanonanedioicacid, 5-[[(1R)-2-(6-aMino-9H-purin-9-yl)-1-Methylethoxy]Methyl]-,1,9-bis(1-Methylethyl) ester, 5-oxide
• TenofivirDisoproxilFumarate
• SRY
• Testis-determining factor
• Tenofovir disoproxil, >=98%
• Tenofovir disoproxil aspartate
• Tenofov ir Disoprox
• (R)-(((((1-(6-Amino-9H-purin-9-yl)propan-2-yl)oxy)methyl)phosphoryl)-bis(oxy))bis(methylene) d
• 5-[[(1r)-2-(6-Amino-9h-Purin-9-Yl)-1-Methylethoxy]Methyl]-2,4,6,8-Tetraoxa-5-Phosphanononanedioic Acid Bis(1-Methylethyl) Ester 5-Oxide
• Tenofovir disoproxil
• 202138-50-9 (1:1 Fumarate salt)
• Aids080741
• Aids-080741
• Bis(isopropyloxymethylcarbonyl)pmpa
• Bis(poc)pmpa
• Gs 4331-05 (*1:1 fumarate salt*)
• Pmpa prodrug
• Tdf
• Tenofovirdisoproxil(Fumaratesalt)
• 9-((R)-2-((Bis(((isopropoxycarbonyl)oxy)methoxy)phosphinyl)methoxy)propyl)adenine
• Bis(isopropyloxycarbonyloxymethyl) ester
• tenofovir disoproxil price
• CS-589
• TENOFOVIR DISOPROXIL (BIS(POC)-PMPA)
• TENOFOVIR DISOPROXIL (GS 4331)
• GS 4331
• Tenofovir Disoproxil Base
• enofovirdisoproxil
• [[(R)-1-メチル-2-(6-アミノ-9H-プリン-9-イル)エトキシ]メチル]ホスホン酸ビス[[(イソプロポキシカルボニル)オキシ]メチル]
• 9-[(R)-2-[[ビス[(イソプロピルオキシカルボニルオキシ)メトキシ]ホスフィニル]メトキシ]プロピル]-9H-プリン-6-アミン
• [[(1R)-1-メチル-2-(6-アミノ-9H-プリン-9-イル)エトキシ]メチル]ホスホン酸ビス[(イソプロポキシカルボニルオキシ)メチル]
• [[(1R)-1-メチル-2-(6-アミノ-9H-プリン-9-イル)エトキシ]メチル]ホスホン酸ビス[[(イソプロポキシ)オキソメトキシ]メチル]
• [(1R)-2-(6-アミノ-9H-プリン-9-イル)-1-メチルエトキシ]メチルホスホン酸ビス(イソプロポキシカルボニルオキシメチル)
• テノホビルジソプロキシル
• ビス({[(プロパン-2-イルオキシ)カルボニル]オキシ}メチル) {[(2R)-1-(6-アミノ-9H-プリン-9-イル)プロパン-2-イル]オキシ}メタンホスホナート
• [[(R)-2-(6-アミノ-9H-プリン-9-イル)-1-メチルエトキシ]メチル]ホスホン酸ビス(イソプロポキシカルボニルオキシメチル)
• [(R)-1-メチル-2-(6-アミノ-9H-プリン-9-イル)エトキシ]メチルホスホン酸ビス(イソプロピルオキシカルボニルオキシメチル)
• 9-[(R)-2-[[ビス[(イソプロポキシカルボニルオキシ)メトキシ]ホスフィニル]メトキシ]プロピル]-9H-プリン-6-アミン