ChemicalBook
Chinese english Germany Korea

エポチロンB

エポチロンB 化学構造式
152044-54-7
CAS番号.
152044-54-7
化学名:
エポチロンB
别名:
エポチロンB;エポチロンB,;エポチロンB (SYNTHETIC)
英語化学名:
Patupilone
英語别名:
EPO 906A;atupilone;Patupilone;EPOTHILONE;Epothilone B;Epothilone B, >=98%;Epothilone B(EPO906);Patupilone(Epothilone B);Epothilone B(Patupilone);EPO906, EpoB, Patupilone
CBNumber:
CB0972824
化学式:
C27H41NO6S
分子量:
507.68
MOL File:
152044-54-7.mol

エポチロンB 物理性質

融点 :
95-97°C
比旋光度 :
D21 -35° (c = 0.7 in methanol)
比重(密度) :
1.136
貯蔵温度 :
Store at -20°C
外見 :
White to off-white solid
色:
colorless
InChIKey:
QXRSDHAAWVKZLJ-PVYNADRNSA-N
CAS データベース:
152044-54-7

安全性情報

WGK Germany  3
HSコード  29419090

エポチロンB 価格 もっと(14)

メーカー 製品番号 製品説明 CAS番号 包装 価格 更新時間 購入
富士フイルム和光純薬株式会社(wako) W01LKTE6257 エポチロンB
Epothilone B
152044-54-7 1mg ¥13700 2018-12-26 購入
富士フイルム和光純薬株式会社(wako) W01LKTE6257 エポチロンB
Epothilone B
152044-54-7 5mg ¥30000 2018-12-26 購入
東京化成工業 E1378 エポチロンB >95.0%(HPLC)
Epothilone B >95.0%(HPLC)
152044-54-7 5mg ¥19000 2018-12-04 購入
東京化成工業 E1378 エポチロンB >95.0%(HPLC)
Epothilone B >95.0%(HPLC)
152044-54-7 25mg ¥67000 2018-12-04 購入
Sigma-Aldrich Japan E2656 from Sorangium cellulosum, ≥98% (HPLC)
(?)-Epothilone B from Sorangium cellulosum, ≥98% (HPLC)
152044-54-7 5mg ¥23800 2018-12-25 購入

エポチロンB 化学特性,用途語,生産方法

化学的特性

White Powder

使用

Epothilones are polyketide natural products that inhibit cancer cells by a mechanism similar to paclitaxel, and also are effective against paclitaxel-resistant tumours. Epothilone B is what is known as a microtubule stabilizer. When a cell divides, the chromosomes that will end up in each cell are separated by thin filaments called microtubules. Normally these microtubules then break down as the cell division progresses. This class of cytotoxic chemo drugs prevents that break down and thus prevents cells from completing division.

使用

Epothilone B is a microtubule inhibitor isolated from the myxobacteria, Sorangium cellulosum. Like epothilone A, epothilone B acts by stabilising microtubule formation at the taxol binding site, and causes cell cycle arrest at the G2/M transition, leading to cytotoxicity.

定義

ChEBI: An epithilone that is epithilone D in which the double bond in the macrocyclic ring has been oxidised to the corresponding epoxide (the S,S stereoisomer).

使用

Epothilone B (Epo B) is a macrolide that causes the formation of bundles of intracellular microtubules in non-mitotic cells, induces the formation of hyperstable tubulin polymers, and arrests cell cycling in mitosis. It induces mitotic arrest at the G2-M transition in Hs578T and HeLa cells (IC50 = 3 and 32 nM, respectively) as well as in multidrug resistant KB3-1 and KBV-1 cells (IC50 = 16 and 92 nM, respectively). Epo B causes cell cycle arrest at nanomolar IC50 values in cell lines from ovarian, breast, lung, colon, prostate, and squamous cancer.

生物活性

Microtubule stabilization agent that promotes tubulin polymerization and induces G 2 -M cell cycle arrest (EC 50 = 3 - 92 nM). Potently inhibits a variety of human cancer cell lines (IC 50 values are 0.13 - 0.64 nM), including MDR cells overexpressing the P-glycoprotein efflux pump. Exhibits potent anticancer activity in numerous human tumor xenografts in vivo .

エポチロンB 上流と下流の製品情報

原材料

準備製品


エポチロンB 生産企業

Global( 138)Suppliers
名前 電話番号 ファックス番号 電子メール 国籍 製品カタログ 優位度
Henan DaKen Chemical CO.,LTD.
+86-371-55531817
info@dakenchem.com CHINA 22043 58
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 20786 55
Mainchem Co., Ltd.
+86-0592-6210733
+86-0592-6210733 sales@mainchem.com CHINA 32651 55
Chemwill Asia Co.,Ltd.
86-21-51086038
86-21-51861608 chemwill_asia@126.com;sales@chemwill.com;chemwill@hotmail.com;chemwill@gmail.com CHINA 24118 58
Hubei Jusheng Technology Co.,Ltd.
86-188-71490254
peter@hubeijusheng.com CHINA 20229 58
QUALITY CONTROL CHEMICALS INC.
(323) 306-3136
(626) 453-0409 orders@qcchemical.com United States 8430 58
career henan chemical co
+86-371-86658258
sales@coreychem.com CHINA 19997 58
Chembest Research Laboratories Limited +86(0)21-20908456
+86(0)21-58180499 sales@biochembest.com; market@biochembest.com China 5999 61
CEG Chemical Science&Technology Co., Ltd. Mobile:13665161512
+86-510-68873513 sales@cegchem.com China 1797 58
Hubei Widely Chemical Technology Co., Ltd. 027-51119224 18602735115
027-51119224 18602735115@163.com China 5018 64

152044-54-7(エポチロンB)キーワード:


  • 152044-54-7
  • Epothilone B, >=98%
  • Patupilone(Epothilone B)
  • atupilone
  • 4,17-Dioxabicyclo14.1.0heptadecane-5,9-dione, 7,11-dihydroxy-8,8,10,12,16-pentamethyl-3-(1E)-1-methyl-2-(2-methyl-4-thiazolyl)ethenyl-, (1S,3S,7S,10R,11S,12S,16R)-
  • EPO 906A
  • (1S,3S,7S,10R,11S,12S,16R)-7,11-Dihydroxy-8,8,10,12,16-pentamethyl-3-[(1E)-1-methyl-2-(2-methyl-4-thiazolyl)ethenyl]-4,17-dioxabicyclo[14.1.0]heptadecane-5,9-dione
  • Epothilone B
  • Patupilone
  • ()-Epothilone B,EPO906, EpoB, Patupilone
  • EPO906, EpoB, Patupilone
  • Epothilone B(EPO906)
  • Epothilone B HOUSE STANDARD
  • Epothilone B(Patupilone)
  • (3S,7S,10R,11S,12S,16R)-7,11-Dihydroxy-8,8,10,12,16-pentaMethyl-3-((E)-1-(2-Methylthiazol-4-yl)prop-1-en-2-yl)-4,17-dioxa-bicyclo[14.1.0]heptadecan-5,9-dione
  • Epothilone B (EPO906, Patupilone)
  • EPOTHILONE
  • (1S,3S,7S,10R,11S,12S,16R,E)-7,11-dihydroxy-8,8,10,12,16-pentamethyl-3-(1-(2-methylthiazol-4-yl)prop-1-en-2-yl)-4,17-dioxa-bicyclo[14.1.0]heptadecane-5,9-dione
  • Patupilone (1S,3S,7S,10R,11S,12S,16R)-7,11-Dihydroxy-8,8,10,12,16-pentamethyl-3-[(1E)-1-methyl-2-(2-methyl-4-thiazolyl)ethenyl]-4,17-dioxabicyclo[14.1.0]heptadecane-5,9-dione
  • エポチロンB
  • エポチロンB,
  • エポチロンB (SYNTHETIC)
Copyright 2017 © ChemicalBook. All rights reserved