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プレリキサフォル

プレリキサフォル 化学構造式
110078-46-1
CAS番号.
110078-46-1
化学名:
プレリキサフォル
别名:
プレリキサフォル;プレリキサホル;プレリキサホル (JAN)
英語化学名:
PLERIXAFOR
英語别名:
CS-269;AMD310;Mozobil;AMD-3329;PLERIXAFOR;Sdz sid 791;Unii-S915p5499n;MOZOBIL PLERIXAFOR;Plerixafor(AMD3100);AMD3100 (Plerixafor)
CBNumber:
CB11011749
化学式:
C28H54N8
分子量:
502.791
MOL File:
110078-46-1.mol

プレリキサフォル 物理性質

融点 :
122-125°C
沸点 :
657.5±55.0 °C(Predicted)
比重(密度) :
0.962
貯蔵温度 :
Refrigerator
酸解離定数(Pka):
10.60±0.20(Predicted)
CAS データベース:
110078-46-1

安全性情報

HSコード  29339900

プレリキサフォル 価格 もっと(8)

メーカー 製品番号 製品説明 CAS番号 包装 価格 更新時間 購入
富士フイルム和光純薬株式会社(wako) W01COBQB-1271 プレリキサフォル
Plerixafor
110078-46-1 250mg ¥144000 2018-12-26 購入
富士フイルム和光純薬株式会社(wako) W01FLC362020
1,4-Bis((1,4,8,11-tetraazacyclotetradecan-1-yl)methyl)benzene
110078-46-1 250mg ¥114800 2018-12-26 購入
富士フイルム和光純薬株式会社(wako) W01MAS097330
1,4-Bis((1,4,8,11-tetraazacyclotetradecan-1-yl)methyl)benzene
110078-46-1 250mg ¥116600 2018-12-26 購入
富士フイルム和光純薬株式会社(wako) W01TRCP580500 プレリキサフォル
Plerixafor
110078-46-1 100mg ¥117500 2018-12-26 購入
富士フイルム和光純薬株式会社(wako) W01TRCP580500 プレリキサフォル
Plerixafor
110078-46-1 10mg ¥27500 2018-12-26 購入

プレリキサフォル 化学特性,用途語,生産方法

効能

抗悪性腫瘍薬, ケモカイン受容体4(CXCR4)拮抗薬

商品名

モゾビル (サノフィ)

説明

Autologous hematopoietic stem cell (HSC) transplantation, a standard treatment for hematological malignancies, such as non-Hodgkin’s lymphoma or multiple myeloma, involves collection of HSCs from the patient, chemo- or radiotherapy of the patient to eliminate malignant cells, and retransplantation of the stored HSCs.
Plerixafor is a potent antagonist of the CXCR4 chemokine receptor and a first-in-class drug for stem cell mobilization. CXCR4 is specific for stromal-derived-factor-1 (SDF-1), a molecule endowed with potent chemotactic activity forlymphocytes. Because the interaction between SDF-1 and CXCR4 plays an important role in holding HSCs in the bone marrow, drugs that block the activity of CXCR4 receptor are capable of mobilizing HSCs into the bloodstream. In vitro, plerixafor potently blocks SDF-1 binding of CXCR4 and inhibits SDF-1-induced calcium flux (IC50 = 0.01-0.13 mg/mL) and chemotaxis (IC50 = 0.13 mg/mL) in several different cell types. Plerixafor, in combination with G-CSF, is specifically indicated to mobilize HSCs to the peripheral blood for collection and subsequent autologous transplantation in patients with non-Hodgkin’s lymphoma and multiple myeloma.

化学的特性

White Solid

Originator

AnorMED (Canada)

使用

Plerixafor is a chemokine receptor antagonist for CXCR4 and CXCL12-mediated chemotaxis with IC50 of 44 nM and 5.7 nM, respectively

使用

Plerixafor is a hematopoietic stem cell (HSC) mobilizer that inhibits the CXCR4 chemokine receptor and blocks binding of its ligand, stromal cell-derived factor-1-α (SDF-1-α). on Dec. 15, 2008, as treatment in combination with granulocyte-colony stimulating factor (G-CSF) to mobilize HSCs to the peripheral blood for collection and subsequent autologous transplantation in p atients with non-Hodgkin's lymphoma (NHL) and multiple myeloma (MM).

brand name

Mozobil

副作用

The most common adverse reactions (occurring in more than 10% of patients) observed during plerixafor use include diarrhea, nausea, fatigue, injection-site reactions, headache, arthralgia, dizziness, and vomiting.

Chemical Synthesis

Plerixafor can be synthesized by several related procedures starting from tetraazacyclotetradecane, the macrocyclic tetraamine cyclam. The general synthetic strategy entails the masking of three of the four ring nitrogens, followed by alkylation with para-xylylene dibromide, and subsequent removal of the masking groups. In one approach, tetraazacyclotetradecane is protected as the phosphorotriamide derivative by reaction with tris (dimethylamino)phosphine followed by oxidation with carbon tetrachloride and sodium hydroxide. After condensation with xylylene dibromide, the dimeric bis-phosphoramide intermediate is hydrolyzed to plerixafor by treatment with dilute hydrochloric acid solution.

プレリキサフォル 上流と下流の製品情報

原材料

準備製品


プレリキサフォル 生産企業

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110078-46-1(プレリキサフォル)キーワード:


  • 110078-46-1
  • CS-269
  • 1;4;8;11-TETRAAZACYCLOTETRADECANE; 1;1'-[1;4-PHENYLENEBIS(METHYLENE)]BIS;AMD 3100;AMD-3100
  • 11-Tetraazacyclotetradecane
  • 4-phenylenebis(methylene)]bis
  • AMD-3329
  • 1,1'-[1,4-Phenylenebis(methylene)]bis-1,4,8,11-tetraazacyclotetradecane
  • 1,4,8,11-Tetraazacyclotetradecane, 1,1'-(1,4-phenylenebis(methylene))bis-
  • Mozobil
  • Sdz sid 791
  • Unii-S915p5499n
  • 1-[[4-(1,4,8,11-tetrazacyclotetradec-1-ylmethyl)phenyl]methyl]-1,4,8,11-tetrazacyclotetradecane
  • Plerixafor(AMD3100)
  • 1-{[4-(1,4,8,11-tetraazacyclotetradecan-1-ylMethyl)phenyl]Methyl}-1,4,8,11-tetraazacyclotetradecane
  • MOZOBIL PLERIXAFOR
  • plerixafor, AMD 3100, AMD-3100, AMD3100, JLK 169, Mozobil, 1-[[4-(1,4,8,11-tetrazacyclotetradec-1-ylMethyl)phenyl] Methyl]-1,4,8,11-tetrazacyclotetradecane
  • PLERIXAFOR
  • Plerixafor/JM3100/AMD3100
  • 1,4-bis((1,4,8,11-tetraazacyclotetradecan-1-yl)Methyl)benzene
  • 1,4-Bis((1,4,8,11-tetraazacyclotetradecan-1-yl)Methyl)benzene,95+%
  • AMD3100 (Plerixafor)
  • AMD310
  • プレリキサフォル
  • プレリキサホル
  • プレリキサホル (JAN)
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