スルファメトキシピリダジン 化学特性,用途語,生産方法
外観
白色〜うすい黄色, 結晶性粉末〜粉末
溶解性
アセトンに溶け、水及びエタノールにほとんど溶けない。
効能
抗菌薬, 葉酸合成阻害薬
化学的特性
White or slightly yellow crystalline powder; odorless, bitter taste; discolored when exposed to light. The product is slightly soluble in acetone, very slightly soluble in ethanol, almost insoluble in water; easily soluble in dilute hydrochloric acid or alkali hydroxide solution.
使用
Sulfamethoxypyridazine is a long-acting sulfonamide antibiotic with anti-inflammatory and antibacterial effects, mainly used for streptococcus, staphylococcus, Escherichia coli and other infections, especially for urinary tract infections.
主な応用
Sulfamethoxypyridazine may be used as a reference standard for the determination of sulfamethoxypyridazine in pharmaceutical formulations by liquid chromatography method.
定義
ChEBI: Sulfamethoxypyridazine is a sulfonamide consisting of pyridazine having a methoxy substituent at the 6-position and a 4-aminobenzenesulfonamido group at the 3-position. It has a role as an antiinfective agent, an EC 2.5.1.15 (dihydropteroate synthase) inhibitor and a drug allergen. It is a member of pyridazines, a sulfonamide and a sulfonamide antibiotic. It derives from a sulfanilamide.
適応症
This drug possesses antibacterial activity with respect to a few cocci and colon bacillus. It
is a long-lasting drug. It is used for treating pneumonia, bronchitis, tonsillitis, purulent otitis
and meningitis, purulent infections of the urinary tract, dysentery, and others. Synonyms of
this drug are sulfapyridazine, sufalex, retasulfin, and many others.
世界保健機関（WHO）
Sulfamethoxypyridazine, a sulfonamide anti-infective agent, was
introduced in 1957 for the treatment of bacterial infections. The importance of
sulfonamides has subsequently decreased as a result of increasing bacterial
resistance and their replacement by antibiotics which are generally more active
and less toxic. The sulfonamides are known to cause serious adverse effects such
as renal toxicity, sometimes fatal exfoliative dermatitis and erythema multiforma
and dangerous adverse reactions affecting blood formation such as
agranulocytosis and haemolytic or aplastic anaemia. Commercial manufacture of
the drug has been discontinued by at least one major manufacturer but supplies
can still be obtained on special request, particularly for patients with dermatitis
herpetiformis in which condition it has been claimed to be beneficial.
一般的な説明
Sulfamethoxypyridazine is a sulfonamide antibiotic mainly used to prevent infections as well as conditions such as coccidiosis, diarrhea and gastroenteritis.
応用例（製薬）
3-Sulfanilamido-6-methoxypyridazine. Properties are similar
to those of sulfadimethoxine. A rapidly absorbed, long-acting
compound (half-life 38 h) with a high degree of protein binding
(96%). A 1 g oral dose achieves a peak plasma concentration
of around 100 mg/L after 5 h. Its use has been largely
discontinued because of frequent adverse effects, but there are
reports of benefit in dermatitis herpetiformis. It has been used
in combination with trimethoprim.
スルファメトキシピリダジン 上流と下流の製品情報
原材料
準備製品