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アラトロフロキサシン

アラトロフロキサシン 化学構造式
146961-76-4
CAS番号.
146961-76-4
化学名:
アラトロフロキサシン
别名:
アラトロフロキサシン
英語化学名:
Alatrofloxacin
英語别名:
D07562;Alatrofloxacin (inn);UUZPPAMZDFLUHD-VUJLHGSVSA-N
CBNumber:
CB11102904
化学式:
C26H25F3N6O5.CH4O3S
分子量:
654.62
MOL File:
146961-76-4.mol

アラトロフロキサシン 物理性質

安全性情報

アラトロフロキサシン 価格

メーカー 製品番号 製品説明 CAS番号 包装 価格 更新時間 購入

アラトロフロキサシン 化学特性,用途語,生産方法

効能

抗菌薬, 核酸合成阻害薬

酵素阻害剤

This fourth-generation fluoroquinolone-class antibiotic (FW = 558.51 g/mol; CAS 146961-76-4; quickly hydrolyzes to form trovafloxacin), also named 7-[(1R,5S)-6-{[(2S)-1-{[(2S)-2-aminopropanoyl]amino}-1-oxopropan- 2-yl]amino}-3-azabicyclo[3.1.0]hexan-3-yl]-1-(2,4-difluorophenyl)-6- fluoro-4-oxo-1,8-naphthyridine-3-carboxylic acid, is a systemic antibacterial that targets Type II DNA topoisomerases (gyrases) required for bacterial replication and transcription. This fluoroquinolone shows an extensive in vitro antibiotic spectrum, with high activity against Grampositive coccus, anaerobic and atypical pneumonia-producing bacteria. (For the prototypical member of this antibiotic class, See Ciprofloxacin) Intravenous alatrofloxacin, followed by oral trovafloxacin (TVX), is safe and well tolerated. Alatrofloxacin also lacks the phototoxicity, cardiovascular toxicity, and hemolytic anemia associated with earlier fluoroquinolones. Given its metabolism to trovafloxacin, it should be noted that the latter significantly increases the formation of nitrotyrosine in mice that are heterozygous for mitochondrial superoxide dismutase-2. Using the NO-selective probe DAF-2, TVX also increases the production of mitochondrial NO in immortalized human hepatocytes. Similarly, mitochondrial Ca2+ is increased by TVX, suggesting calcium ion-dependent activation of mitochondrial NOS activity. The relationship between these observations and trovafloxacin-induced leukopenia remains to be explored.

アラトロフロキサシン 上流と下流の製品情報

原材料

準備製品


アラトロフロキサシン 生産企業

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