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ペチジン

ペチジン 化学構造式
57-42-1
CAS番号.
57-42-1
化学名:
ペチジン
别名:
ペチジン;メペリジン
英語化学名:
MEPERIDINE
英語别名:
Lydol;C07128;Dolsin;Nemerol;Demarol;Demerol;Petantin;Pethanol;Pethidin;Petydyna
CBNumber:
CB1121049
化学式:
C15H21NO2
分子量:
247.33
MOL File:
57-42-1.mol

ペチジン 物理性質

融点 :
270°C
沸点 :
390.37°C (rough estimate)
比重(密度) :
1.0267 (rough estimate)
屈折率 :
1.5130 (estimate)
闪点 :
11 °C
貯蔵温度 :
−20°C
酸解離定数(Pka):
pKa 8.7 (Uncertain)
水溶解度 :
6.55g/L(25 ºC)
EPAの化学物質情報:
4-Piperidinecarboxylic acid, 1-methyl-4-phenyl-, ethyl ester (57-42-1)
安全性情報
  • リスクと安全性に関する声明
  • 危険有害性情報のコード(GHS)
主な危険性  F,T
Rフレーズ  11-23/24/25-39/23/24/25
Sフレーズ  7-16-36/37-45
RIDADR  UN 1230 3/PG 2
WGK Germany  1
絵表示(GHS)
注意喚起語 Danger
危険有害性情報
コード 危険有害性情報 危険有害性クラス 区分 注意喚起語 シンボル P コード
H225 引火性の高い液体および蒸気 引火性液体 2 危険 P210,P233, P240, P241, P242, P243,P280, P303+ P361+P353, P370+P378,P403+P235, P501
H370 臓器の障害 特定標的臓器有害性、単回暴露 1 危険 P260, P264, P270, P307+P311, P321,P405, P501
注意書き
P210 熱/火花/裸火/高温のもののような着火源から遠ざ けること。-禁煙。
P260 粉じん/煙/ガス/ミスト/蒸気/スプレーを吸入しないこ と。
P280 保護手袋/保護衣/保護眼鏡/保護面を着用するこ と。
P301+P310 飲み込んだ場合:直ちに医師に連絡すること。
P311 医師に連絡すること。

ペチジン 価格

メーカー 製品番号 製品説明 CAS番号 包装 価格 更新時間 購入

ペチジン 化学特性,用途語,生産方法

効能

麻薬性鎮痛薬, オピオイド受容体作動薬

使用

Analgesic (narcotic).

brand name

Demerol (Hospira); Demerol (Sanofi Aventis).

生物学の機能

Meperidine (Demerol) is a phenylpiperidine derivative of morphine that was developed in the late 1930s as a potential anticholinergic agent. It has some anticholinergic side effects that lead to tachycardia, blurred vision, and dry mouth. Meperidine is approximately onefifth as potent as morphine and is absorbed only half as well when administered orally as parenterally. It has a rapid onset and short duration of action (2 hours), that is, approximately one-fourth that of morphine.
Like morphine, meperidine has an active metabolite, normeperidine, formed by N-demethylation of meperidine. Normeperidine is not analgesic but is a proconvulsant and a hallucinogenic agent. For this reason, meperidine use in patients with renal or liver insufficiency is contraindicated because of the decreased clearance of the drug and its metabolite. Convulsant activity has been documented in elderly patients given meperidine and in patients using PCA who have decreased renal function.
Meperidine differs from morphine in that it has far less antitussive effect and little constipative effect. The drug is particularly useful in cancer patients and in pulmonary patients, in whom the cough reflex must remain intact. However, it does have more seizure-inducing activity than morphine. Although meperidine produces spasms of the biliary tract and colon, such spasms are of shorter duration than those produced by morphine.
Meperidine readily passes the placenta into the fetus. However, respiratory depression in the newborn has not been observed, and meperidine clearance in the newborn is rapid in that it does not rely upon conjugation to glucuronides. Meperidine, unlike morphine, has not been associated with prolongation of labor; conversely, it increases uterine contractions.

一般的な説明

Meperidine (Demerol) was discovered in 1939 during a serendipitous screening of compounds being studied for antispasmodic activity. Mice given meperidine were noted to carry their tails in an erect position (the Straub tail reaction), which was indicative of narcotic analgesia. This led to the study of meperidine and derivatives as analgesic agents. Meperidine was found to have low potency at the receptor compared with morphine (0.2%) but much higher penetration into the brain resulting in a compound with about 10% of the potency of morphine.
Structural changes that increase the potency of meperidine include the introduction of an mhydroxyl on the phenyl ring, substituting the methyl on the N for a phenylethyl or a p-aminophenylethyl. Replacing the N-methyl with an N-allyl or N-cyclopropylmethyl group does not generate an antagonist, unlike the similar substitution of the morphine congeners. Meperidine quickly penetrates the blood-brain barrier and thus has a quick onset of activity and a high abuse potential.

予防処置

Contraindications are similar to those of morphine. In addition, because normeperidine accumulates in renal dysfunction and meperidine accumulates in hepatic dysfunction, meperidine is contraindicated in such patients because of convulsant effects. Similarly, the use of meperidine is contraindicated in patients who have a history of seizures or who are taking medication to prevent seizures. Phenytoin administered for seizures may reduce the effectiveness of meperidine by increasing the metabolism of the drug in the liver. Meperidine is not generally used in patients with cardiac dysfunction, since its anticholinergic effects can increase both heart rate and ectopic beats.

ペチジン 上流と下流の製品情報

原材料

準備製品


ペチジン 生産企業

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57-42-1(ペチジン)キーワード:


  • 57-42-1
  • MEPERIDINE
  • 1-Methyl-4-phenyl-4-piperidinecarboxylic acid ethyl ester
  • 1-methyl-4-phenyl-4-piperidinecarboxylicacidethylester
  • ethyl1-methyl-4-phenylisonipecotate
  • ethyl1-methyl-4-phenylpiperidine-4-carboxylate
  • Isonipecaine
  • Isonipecotic acid, 1-methyl-4-phenyl-, ethyl ester
  • Lydol
  • Meperidine (demerol))
  • Meperidol
  • Methyl phenylpiperidine carbonic acid ethyl ester
  • methylphenylpiperidinecarbonicacidethylester
  • Nemerol
  • N-Methyl-4-phenyl-4-carbethoxypiperidine
  • Petantin
  • Pethanol
  • Pethidin
  • Pethidine
  • Pethidineter
  • Petydyna
  • Phetidine
  • Piperosal
  • Pipersal
  • Mepergan
  • Pamergan
  • Mepridine
  • 4-Piperidinecarboxylic acid, 1-methyl-4-phenyl-, ethyl ester
  • PETHIDINEHCL(DANGEROUSDRUG)
  • PETHIDINE/MEPERIDINE
  • Meperidine solution
  • ペチジン
  • メペリジン
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