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ニコチンアミド

ニコチンアミド 化学構造式
98-92-0
CAS番号.
98-92-0
化学名:
ニコチンアミド
别名:
ニコチンアミド;ニコチン酸アミド;ペロニンアミド;ベニコート;3-ピリジンカルボアミド;ニオジミン;アミニコチン;ピリジン-3-カルボアミド;ニアシナミド;ベコニット;3-ピリジンカルボキサミド;ニアシンアミド;ニカミンドン;ナイアシンアミド;ニコチラミド;ニコサン2;3-カルバモイルピリジン;ニコホルト;ジペギル;ビタミンB3
英語化学名:
Nicotinamide
英語别名:
Nicota;Pelmin;Nicofo;amidepp;Benicot;Dipegyl;Dipigyl;VB3、VPP;Nicasir;Nicogen
CBNumber:
CB1130111
化学式:
C6H6N2O
分子量:
122.12
MOL File:
98-92-0.mol

ニコチンアミド 物理性質

融点 :
128-131 °C(lit.)
沸点 :
150-160 °C
比重(密度) :
1.40
蒸気密度:
4.22 (vs air)
屈折率 :
1.4660 (estimate)
闪点 :
182 °C
貯蔵温度 :
2-8°C
溶解性:
691g/l
酸解離定数(Pka):
3.3(at 20℃)
外見 :
powder
色:
white
PH:
6.0-7.5 (50g/l, H2O, 20℃)
臭い (Odor):
Odorless
酸塩基指示薬変色域(pH):
9
水溶解度 :
1000 g/L (20 ºC)
Decomposition :
>=200 °C
Merck :
14,6523
BRN :
383619
安定性::
Stable. Incompatible with strong oxidizing agents.
InChIKey:
DFPAKSUCGFBDDF-UHFFFAOYSA-N
CAS データベース:
98-92-0(CAS DataBase Reference)
NISTの化学物質情報:
Niacinamide(98-92-0)
EPAの化学物質情報:
Nicotinamide (98-92-0)
安全性情報
  • リスクと安全性に関する声明
  • 危険有害性情報のコード(GHS)
主な危険性  Xi,T,F
Rフレーズ  36/37/38-39/23/24/25-23/24/25-11
Sフレーズ  26-36-37/39-45-36/37-16-7
RIDADR  UN1230 - class 3 - PG 2 - Methanol, solution
WGK Germany  1
RTECS 番号 QS3675000
8
自然発火温度 480 °C
TSCA  Yes
HSコード  29362990
有毒物質データの 98-92-0(Hazardous Substances Data)
毒性 LD50 s.c. in rats: 1.68 g/kg (Brazda, Coulson)
化審法 (5)-736
絵表示(GHS)
注意喚起語 Danger
危険有害性情報
コード 危険有害性情報 危険有害性クラス 区分 注意喚起語 シンボル P コード
H225 引火性の高い液体および蒸気 引火性液体 2 危険 P210,P233, P240, P241, P242, P243,P280, P303+ P361+P353, P370+P378,P403+P235, P501
H315 皮膚刺激 皮膚腐食性/刺激性 2 警告 P264, P280, P302+P352, P321,P332+P313, P362
H319 強い眼刺激 眼に対する重篤な損傷性/眼刺激 性 2A 警告 P264, P280, P305+P351+P338,P337+P313P
H335 呼吸器への刺激のおそれ 特定標的臓器毒性、単回暴露; 気道刺激性 3 警告
H370 臓器の障害 特定標的臓器有害性、単回暴露 1 危険 P260, P264, P270, P307+P311, P321,P405, P501
注意書き
P210 熱/火花/裸火/高温のもののような着火源から遠ざ けること。-禁煙。
P260 粉じん/煙/ガス/ミスト/蒸気/スプレーを吸入しないこ と。
P261 粉じん/煙/ガス/ミスト/蒸気/スプレーの吸入を避ける こと。
P264 取扱い後は皮膚をよく洗うこと。
P264 取扱い後は手や顔をよく洗うこと。
P280 保護手袋/保護衣/保護眼鏡/保護面を着用するこ と。
P301+P310 飲み込んだ場合:直ちに医師に連絡すること。
P305+P351+P338 眼に入った場合:水で数分間注意深く洗うこと。次にコ ンタクトレンズを着用していて容易に外せる場合は外す こと。その後も洗浄を続けること。
P311 医師に連絡すること。
P337+P313 眼の刺激が続く場合:医師の診断/手当てを受けること。

ニコチンアミド 価格 もっと(44)

メーカー 製品番号 製品説明 CAS番号 包装 価格 更新時間 購入
富士フイルム和光純薬株式会社(wako) W01W0114-0120 ニコチンアミド 98.0+% (Titration)
Nicotinamide 98.0+% (Titration)
98-92-0 25g ¥1850 2021-03-23 購入
富士フイルム和光純薬株式会社(wako) W01W0114-0120 ニコチンアミド 98.0+% (Titration)
Nicotinamide 98.0+% (Titration)
98-92-0 500g ¥6300 2021-03-23 購入
東京化成工業 N0078 ニコチンアミド >99.0%(HPLC)(T)
Nicotinamide >99.0%(HPLC)(T)
98-92-0 500g ¥6400 2021-03-23 購入
東京化成工業 N0078 ニコチンアミド >99.0%(HPLC)(T)
Nicotinamide >99.0%(HPLC)(T)
98-92-0 25g ¥1600 2021-03-23 購入
関東化学株式会社(KANTO) 28141-00 ニコチンアミド >98.0%(T)
Nicotinamide >98.0%(T)
98-92-0 500g ¥6400 2021-03-23 購入

ニコチンアミド MSDS


3-Pyridinecarboxamide

ニコチンアミド 化学特性,用途語,生産方法

外観

白色, 結晶~結晶性粉末

定義

本品は、次の化学式で表される複素環式芳香族アミドである。

溶解性

水又はエタノールに易溶, ジエチルエーテルに難溶。

解説

3-pyridinecarboxamide.C6H6N2O(122.12).ナイアシンアミドともいう.ビタミンB複合体の一つで,ヒトの抗ペラグラ因子.動物,植物界にニコチン酸とともに広く分布しているが,ニコチン酸エステルの高圧,加熱アンモニア処理で得られる."白色の結晶.融点128~131 ℃.λmax 261 nm(ε 4.7,0.1 mol L-1 塩酸).水,エタノール,グリセリンに易溶,ほかの有機溶媒に不溶.ニコチン酸アミドは二つの補酵素,NADおよびNADPの構成成分であり,生体中の酸化還元反応に関与している.[CAS 98-92-0]
森北出版「化学辞典(第2版)

用途

薬理・医薬品研究用

化粧品の成分用途

ヘアコンディショニング剤、皮膚コンディショニング剤

効能

ニコチン酸補充薬

商品名

ニコチン酸アミド (ゾンネボード製薬)

説明

A white, crystalline powder. It is odorless or nearly so, and has a bitter taste. Its solutions are neutral to litmus. One g dissolves in about 1 mL of water, in about 1.5 mL of alcohol, and in about 10 mL of glycerin.

化学的特性

Niacinamide is a white crystalline powder or forms colorless needle-like crystals.

Originator

Niacinamide,Twinlab

使用

niacinamide is used as a skin stimulant and skin smoother. It is a derivative of niacin, and part of the vitamin B family.

使用

Niacinamide is a nutrient and dietary supplement that is an available form of niacin. Nicotinic acid is pyridine beta-carboxylic acid and nicotinamide, which is another term for niacinamide, is the corresponding amide. It is a powder of good water solubility, having a solubility of 1 g in 1 ml of water. Unlike niacin, it has a bitter taste; the taste is masked in the encapsulated form. Used in fortification of cereals, snack foods, and powdered beverages.

使用

A water-soluble vitamin B, incorporated within nicotinamide cofactors such as NADH and NADPH.

使用

Vitamin B3; enzyme cofactor; anti-pellagra

使用

Niacinamide USP is used as food additive, for multivitamin preparations and as intermediate for pharmaceuticals and cosmetics.

定義

ChEBI: A pyridinecarboxamide that is pyridine in which the hydrogen at position 3 is replaced by a carboxamide group.

Manufacturing Process

Gaseous ammonia was passed into nicotinic acid at a temperature between 200-235°C until the conversion to nicotinamide was 85%. The reaction mixture was colored light brown. The reaction mass was cooled and grounds to a fine powder. Fifty grams of this crude nicotinamide were boiled with 500 ml of anhydrous ethyl acetate until a dark solution was. obtained. A little solid remained in suspension. Gaseous ammonia was passed in below the surface of the ethyl acetate at a temperature between 60-70°C. After a short time ammonium nicotinate started to precipitate out of solution as a brown solid. Sufficient gaseous ammonia, was passed into the ethyl acetate solution to insure complete precipitation of the nicotinic acids as ammonium nicotinate. The solution was filtered at about 60-70°C. The filter cake consisted of ammonium nicotinate, which, upon drying, weighed 12.4 grams. The filtrate was stirred arid boiled for 20 minutes with one-half gram of activated carbon and two grams of activated adsorbent clay. The mixture was filtered hot. The filtrate was boiled twenty minutes with one-half gram of activated carbon and two grams of activated adsorbent clay and then filtered hot. The carbon and clay treatment was repeated once more. The final filtrate was cooled slowly with stirring to room temperature to precipitate white crystalline nieocinamide which, upon drying, weighed 26.7 grams and had a melting point of 129.5°C, and was over 99 percent pure. The mother liquor from the above filtration was boiled down to one-third of its volume and cooled to room temperature. A second crop of nicotinamide of three grams was obtained.

Therapeutic Function

Enzyme cofactor vitamin

Synthesis Reference(s)

Journal of the American Chemical Society, 76, p. 5774, 1954 DOI: 10.1021/ja01651a043
Tetrahedron Letters, 36, p. 8657, 1995 DOI: 10.1016/0040-4039(95)01785-G

一般的な説明

Vitamin B3 was formerly called nicotinic acid; however, the term niacin is now preferred to avoid any confusion with the alkaloid, nicotine. Niacinamide, also known as nicotinamide, refers to the amide derivative of niacin that is equivalent in vitamin activity. Some texts use niacin to refer to nicotinic acid, niacinamide, and any derivatives with vitamin activity comparable to niacin. Furthermore, research and chemistry-based resources use the terms nicotinic acid and nicotinamide; whereas pharmacy resources use niacin and niacinamide.

一般的な説明

White powder.

空気と水の反応

Water soluble.

反応プロフィール

An amine and amide. Acts as a weak base in solution. Amines are chemical bases. They neutralize acids to form salts plus water. These acid-base reactions are exothermic. The amount of heat that is evolved per mole of amine in a neutralization is largely independent of the strength of the amine as a base. Amines may be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Flammable gaseous hydrogen is generated by amines in combination with strong reducing agents, such as hydrides. Organic amides/imides react with azo and diazo compounds to generate toxic gases. Flammable gases are formed by the reaction of organic amides/imides with strong reducing agents. Amides are very weak bases (weaker than water). Imides are less basic yet and in fact react with strong bases to form salts. That is, they can react as acids. Mixing amides with dehydrating agents such as P2O5 or SOCl2 generates the corresponding nitrile. The combustion of these compounds generates mixed oxides of nitrogen (NOx).

臨床応用

Niacin is used in the treatment of niacin deficiency, which is referred to as pellagra (from the Italian, pelle for “skin” and agra for “dry”). The major systems affected are the gastrointestinal tract (diarrhea, enteritis and stomatitis), the skin (dermatitis), and the CNS (generalized neurological deficits including dementia). Pellagra has become a rare condition in the United States and other countries that require or encourage enrichment of wheat flour or fortification of cereals with niacin. Because the nucleotide form can be synthesized in vivo from tryptophan, pellagra is most often seen in areas where the diet is deficient in both niacin and tryptophan. Typically, maize (corn)-based diets meet this criteria. Niacin deficiency can also result from diarrhea, cirrhosis, alcoholism, or Hartnup disease. It is interesting that niacin deficiency can also, rarely, result from vitamin B6 deficiency (see Vitamin B6 section). Niacin, but not niacinamide, is also one of the few vitamins that are useful in the treatment of diseases unrelated to deficiencies.

安全性プロファイル

Moderately toxic by ingestion, intravenous, intraperitoneal, and subcutaneous routes. Mutation data reported. When heated to decomposition it emits toxic fumes of NOx.

職業ばく露

Used as a dietary supplement and food additive.

純化方法

Crystallise niacin from *benzene. It has solubility in g/ml: H2O (1), EtOH (0.7) and glycerol (0.1). [Methods in Enzymology 66 23 1980, UV: Armarego Physical Methods in Heterocyclic Chemistry (Ed Katritzky, Academic Press) Vol III 83 1971, Beilstein 22 III/IV 389, 22/2 V 80.]

不和合性

Combustible solid; dust may form explosive mixture with air. Amides are incompatible with oxidizers (chlorates, nitrates, peroxides, permanganates, perchlorates, chlorine, bromine, fluorine, etc.); contact may cause fires or explosions. Keep away from alkaline materials, strong bases, strong acids, oxoacids, epoxides.

ニコチンアミド 上流と下流の製品情報

原材料

準備製品


ニコチンアミド 生産企業

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98-92-0(ニコチンアミド)キーワード:


  • 98-92-0
  • NicotinamideForBiochemistry
  • NicotinamideB.P.,U.S.P.
  • Niacinamide/Nicotinamide
  • Nicotinamide(Niacinamide)Nicotinamide(Niacinamide)Bp/Usp
  • Nicotinamide,98%
  • Vitamin B3
  • Nicotinamidum
  • NIACINAMIDE USP GRANULAR
  • NICOTINAMIDE, 99+%
  • NICOTINAMIDE, PH EUR
  • NICOTINAMIDE (NIACINAMIDE) 1000MG NEAT
  • NIACINAMIDE CELL CULTURE TESTED
  • Niacinamide FCC/USP
  • Amid kyseliny nikotinove
  • Amide PP
  • amidepp
  • amidkyselinynikotinove
  • -Amidopyridine
  • Aminicotin
  • Amixicotyn
  • Amnicotin
  • Austrovit PP
  • austrovitpp
  • Benicot
  • beta-Pyridinecarboxamide
  • component of Medriatric
  • Delonin Amide
  • deloninamide
  • Dipegyl
  • Dipigyl
  • ニコチンアミド
  • ニコチン酸アミド
  • ペロニンアミド
  • ベニコート
  • 3-ピリジンカルボアミド
  • ニオジミン
  • アミニコチン
  • ピリジン-3-カルボアミド
  • ニアシナミド
  • ベコニット
  • 3-ピリジンカルボキサミド
  • ニアシンアミド
  • ニカミンドン
  • ナイアシンアミド
  • ニコチラミド
  • ニコサン2
  • 3-カルバモイルピリジン
  • ニコホルト
  • ジペギル
  • ビタミンB3
  • ニコチンアミド標準品
  • ニコチン酸アミド (JP17)
  • ビタミン
  • 生化学
  • ビタミンB群
  • 代謝作用薬
  • 植物成長促進剤
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