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A denaturation product of cytochrome
P450 often produced during the preparation of microsomes.
The carbon monoxide difference spectrum has a prominent
absorption peak at 420 nm. Although without oxidative activity,
cytochrome P420 binds carbon monoxide and many type II
ligands. Its formation, which appears to be irreversible, is
believed to be due to rupture of a sulfatide bridge between the
heme iron and a protein cysteine residue. |
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