GW405833
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- CAS番号.
- 180002-83-9
- 化学名:
- GW405833
- 别名:
- GW405833;GW405833 塩酸塩;1-(2,3-ジクロロベンゾイル)-5-メトキシ-2-メチル-3-[2-(モルホリン-4-イル)エチル]-1H-インドール;1-(2,3-ジクロロベンゾイル)-5-メトキシ-2-メチル-3-(2-モルホリノエチル)-1H-インドール
- 英語名:
- 1-(2,3-DICHLOROBENZOYL)-5-METHOXY-2-METHYL-3-[2-(4-MORPHOLINYL)ETHYL]-1H-INDOLE
- 英語别名:
- L-768242;GW 405833;GW405833 hydrochloride;1-(2,3-DICHLOROBENZOYL)-5-METHOXY-2-METHYL-3-[2-(4-MORPHOLINYL)ETHYL]-1H-INDOLE;(2,3-Dichloro-phenyl)-[5-Methoxy-2-Methyl-3-(2-Morpholin-4-yl-ethyl)-indol-1-yl];(2,3-DICHLORO-PHENYL)-[5-METHOXY-2-METHYL-3-(2-MORPHOLIN-4-YL-ETHYL)-INDOL-1-YL]-METHAN;(2,3-DICHLORO-PHENYL)-[5-METHOXY-2-METHYL-3-(2-MORPHOLIN-4-YL-ETHYL)-INDOL-1-YL]-METHANONE;(2,3-Dichlorophenyl)[5-methoxy-2-methyl-3-[2-(4-morpholinyl)ethyl]-1H-indol-1-yl]methanone;Methanone,(2,3-dichlorophenyl)[5-methoxy-2-methyl-3-[2-(4-morpholinyl)ethyl]-1H-indol-1-yl]-;1-(2,3-Dichlorobenzoyl)-5-methoxy-2-methyl-(3-(morpholin-4-yl)ethyl)-1H-indole hydrochloride
- CBNumber:
- CB1148019
- 化学式:
- C23H24Cl2N2O3
- 分子量:
- 447.35
- MOL File:
- 180002-83-9.mol
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GW405833 物理性質
- 融点 :
- 47-49℃
- 貯蔵温度 :
- 2-8°C
- 溶解性:
- DMSO に 10 ～ 15 mg/ml で溶解します。約 5 mg/ml のエタノールにも溶けます。
- 外見 :
- 個体
- 色:
- タン
安全性情報
- リスクと安全性に関する声明
- 危険有害性情報のコード(GHS)
| 主な危険性 |
T |
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| Rフレーズ |
25 |
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| Sフレーズ |
45 |
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| RIDADR |
UN 2811 6.1/PG 3 |
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| WGK Germany |
3 |
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| 国連危険物分類 |
6.1 |
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| 絵表示（GHS） |
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| 注意喚起語 |
危険 |
| 危険有害性情報 |
| コード |
危険有害性情報 |
危険有害性クラス |
区分 |
注意喚起語 |
シンボル |
P コード |
| H301 |
飲み込むと有毒 |
急性毒性、経口 |
3 |
危険 |
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P264, P270, P301+P310, P321, P330,P405, P501 |
| H413 |
長期的影響により水生生物に有害のおそれ |
水生環境有害性、慢性毒性 |
4 |
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| 注意書き |
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| メーカー |
製品番号 |
製品説明 |
CAS番号 |
包装 |
価格 |
更新時間 |
購入 |
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富士フイルム和光純薬株式会社(wako)
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W01TOC2374 |
GW405833
GW 405833 |
180002-83-9 |
10mg |
￥50000 |
2020-09-21 |
購入 |
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Sigma-Aldrich Japan
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G1421 |
GW405833 塩酸塩 ≥98% (HPLC), solid
GW405833 hydrochloride ≥98% (HPLC), solid |
180002-83-9 |
5mg |
￥20000 |
2024-03-01 |
購入 |
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Sigma-Aldrich Japan
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G1421 |
GW405833 塩酸塩 ≥98% (HPLC), solid
GW405833 hydrochloride ≥98% (HPLC), solid |
180002-83-9 |
25mg |
￥83700 |
2024-03-01 |
購入 |
GW405833 化学特性,用途語,生産方法
使用
It is a potent and selective CB2 receptor partial agonist (EC50 = 0.65 nM; maximum inhibition = 44.6%). Binds with high affinity to both human and rat CB2 receptors and displays ~ 1200-fold selectivity over CB1 (Ki values are 3.92 and 4772 nM for human recombinant CB2 and CB1 receptors respectively). Produces potent antihyperalgesic effects in several rodent models of pain.
生物活性
Potent and selective CB 2 receptor partial agonist (EC 50 = 0.65 nM; maximum inhibition = 44.6%). Binds with high affinity to both human and rat CB 2 receptors and displays ~ 1200-fold selectivity over CB 1 (K i values are 3.92 and 4772 nM for human recombinant CB 2 and CB 1 receptors respectively). Produces potent antihyperalgesic effects in several rodent models of pain.
Biochem/physiol Actions
GW405833 is a selective cannabanoid CB2 receptor agonist; analgesic. GW405833 binds with high affinity at both human and rat CB2 receptors (Ki′s 3.9 and 3.6 nM); acts as a partial agonist (50% inhibition of forskolin-stimulated cAMP formation compared to full agonist CP55,940). GW405833 has potent analgesic activity in rat models of inflammatory, neuropathic and incisional pain; devoid of CNS effects common with CB1 agonists.
GW405833 上流と下流の製品情報
原材料
準備製品
GW405833 生産企業
Global( 56)Suppliers
180002-83-9(GW405833)キーワード:
- 180002-83-9
- GW 405833
- (2,3-DICHLORO-PHENYL)-[5-METHOXY-2-METHYL-3-(2-MORPHOLIN-4-YL-ETHYL)-INDOL-1-YL]-METHANONE
- 1-(2,3-DICHLOROBENZOYL)-5-METHOXY-2-METHYL-3-[2-(4-MORPHOLINYL)ETHYL]-1H-INDOLE
- 1-(2,3-Dichlorobenzoyl)-5-methoxy-2-methyl-(3-(morpholin-4-yl)ethyl)-1H-indole hydrochloride
- GW405833 hydrochloride
- (2,3-Dichloro-phenyl)-[5-Methoxy-2-Methyl-3-(2-Morpholin-4-yl-ethyl)-indol-1-yl]
- Methanone,(2,3-dichlorophenyl)[5-methoxy-2-methyl-3-[2-(4-morpholinyl)ethyl]-1H-indol-1-yl]-
- (2,3-dichlorophenyl)-[5-methoxy-2-methyl-3-[2-(4-morpholinyl)ethyl]-1-indolyl]methanone hydrochloride
- L-768242
- (2,3-DICHLORO-PHENYL)-[5-METHOXY-2-METHYL-3-(2-MORPHOLIN-4-YL-ETHYL)-INDOL-1-YL]-METHAN
- (2,3-Dichlorophenyl)[5-methoxy-2-methyl-3-[2-(4-morpholinyl)ethyl]-1H-indol-1-yl]methanone
- GW405833,GW 405833,Cannabinoid Receptor,GW-405833,L768242,anti-inflammatory,Inhibitor,L 768242,neuropathic pain,inhibit
- GW405833
- GW405833 塩酸塩
- 1-(2,3-ジクロロベンゾイル)-5-メトキシ-2-メチル-3-[2-(モルホリン-4-イル)エチル]-1H-インドール
- 1-(2,3-ジクロロベンゾイル)-5-メトキシ-2-メチル-3-(2-モルホリノエチル)-1H-インドール