モノクローナル抗ヒトIGE抗体 マウス宿主抗体 化学特性,用途語,生産方法
使用
To confirm that a chimaeric monoclonal antibody had episolon chain, an elisa was performed using monoclonal anti-human IgE antibody (clone GE1) at a 1:1000 dilution.
一般的な説明
Monoclonal Anti-Human IgE (mouse IgG2b isotype) is derived from the hybridoma produced by the fusion of mouse myeloma cells and splenocytes from an immunized mouse. Immunoglobulin E?(IgE) antibodies are tetramers with two light chains (κ or λ) and two ε-heavy connected by numerous intrachain disulfide bonds. IgE exists in two isoforms, one is associated with the B cell?receptor and the other being secreted by plasma cell. It has a short life span in plasma when compared to receptor bounded IgE.
Biochem/physiol Actions
Immunoglobulin E?(IgE) is implicated in acute allergic reactions and chronic inflammatory allergic?diseases, such as allergic asthma and chronic urticaria (CU). Receptor bounded IgE aids?antigen uptake and modulates the differentiation and proliferation of?B?cells.?It confers immunity against helminthic parasites. IgE is also involved in facilitating?type I hypersensitivity reactions. It regulates mast cell homeostasis and also exhibits immunomodulatory effects.
モノクローナル抗ヒトIGE抗体 マウス宿主抗体 上流と下流の製品情報
原材料
準備製品