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127935GR塩酸塩

127935GR塩酸塩 化学構造式
148642-42-6
CAS番号.
148642-42-6
化学名:
127935GR塩酸塩
别名:
127935GR塩酸塩
英語名:
N-[4-Methoxy-3-(4-methyl-1-piperazinyl)phenyl]-2-methyl-4-(5-methyl-1,2,4-oxadiazol-3-yl)-1,1-biphenyl-4-carboxamide hydrate hydrochloride
英語别名:
GR 127935 hydrate hydrochloride;GR-127935 hydrochloride (GR127935);N-[4-Methoxy-3-(4-methyl-1-piperazinyl)phenyl]-2-methyl-4-(5-methyl-1,2,4-oxadiazol-3-yl)-1,1-biphenyl-4-carboxamide hydrochloride hydrate;N-[4-Methoxy-3-(4-methyl-1-piperazinyl)phenyl]-2-methyl-4-(5-methyl-1,2,4-oxadiazol-3-yl)-1,1-biphenyl-4-carboxamide hydrate hydrochloride
CBNumber:
CB12102772
化学式:
C29H31N5O3HCl
分子量:
0
MOL File:
148642-42-6.mol

127935GR塩酸塩 物理性質

貯蔵温度 :
2-8°C
溶解性:
DMSO：可溶10mg/mL、透明
外見 :
粉
色:
白からベージュ
水溶解度 :
Soluble to 100 mM in water

安全性情報

WGK Germany  3

127935GR塩酸塩 価格 もっと(4)

メーカー 製品番号 製品説明 CAS番号 包装 価格 更新時間 購入
富士フイルム和光純薬株式会社(wako) W01TOC1477 127935GR塩酸塩
GR 127935 hydrochloride 		148642-42-6 10mg ￥74000 2024-03-01 購入
富士フイルム和光純薬株式会社(wako) W01TOC1477 127935GR塩酸塩
GR 127935 hydrochloride 		148642-42-6 50mg ￥313000 2024-03-01 購入
Sigma-Aldrich Japan G5793 GR 127935 塩酸塩 水和物 >98% (HPLC), powder
GR 127935 hydrochloride hydrate >98% (HPLC), powder		 148642-42-6 10mg ￥47300 2024-03-01 購入
Sigma-Aldrich Japan G5793 GR 127935 塩酸塩 水和物 >98% (HPLC), powder
GR 127935 hydrochloride hydrate >98% (HPLC), powder		 148642-42-6 50mg ￥239800 2018-12-25 購入

127935GR塩酸塩 化学特性,用途語,生産方法

説明

GR127935 is an antagonist of the serotonin (5-HT) receptor subtypes 5-HT1B, 5-HT1Dα, and 5-HT1Dβ (IC50s = 3.16, 1.26, and 0.13 nM, respectively). It is selective for the 5-HT1B and 5-HT1D receptors over other 5-HT receptors (IC50s = 39.81->10,000 nM in radioligand binding assays). GR127935 increases extracellular 5-HT levels in the guinea pig frontal cortex and prevents increases in 5-HT in rat frontal cortex induced by the selective serotonin reuptake inhibitor paroxetine . It enhances memory consolidation in an autoshaping learning task in rats when administered post-training at a dose of 10 mg/kg. It has been used to elucidate the 5-HT receptor subtypes involved in the anti-inflammatory activity of sumatriptan following myocardial ischemia-reperfusion injury and testicular torsion/detorsion.

使用

GR 127935 Hydrochloride is a selective and potent 5-HT1B/1D serotonin receptor antagonist.

Biochem/physiol Actions

Potent, selective and orally active 5-HT1B/1D serotonin receptor antagonist.

127935GR塩酸塩 上流と下流の製品情報

原材料

準備製品

127935GR塩酸塩 生産企業

Global( 38)Suppliers
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ShangHai Biochempartner Co.,Ltd 17754423994 17754423994
 2853530910@QQ.com China 8014 62

148642-42-6(127935GR塩酸塩)キーワード:

銀
  • 148642-42-6
  • GR 127935 hydrate hydrochloride
  • N-[4-Methoxy-3-(4-methyl-1-piperazinyl)phenyl]-2-methyl-4-(5-methyl-1,2,4-oxadiazol-3-yl)-1,1-biphenyl-4-carboxamide hydrate hydrochloride
  • N-[4-Methoxy-3-(4-methyl-1-piperazinyl)phenyl]-2-methyl-4-(5-methyl-1,2,4-oxadiazol-3-yl)-1,1-biphenyl-4-carboxamide hydrochloride hydrate
  • GR-127935 hydrochloride (GR127935)
  • 127935GR塩酸塩
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