ベダキリン

ベダキリン 価格 もっと(6)

メーカー	製品番号	製品説明	CAS番号	包装	価格	更新時間	購入
富士フイルム和光純薬株式会社(wako)	W01COBQV-7478	Bedaquiline	843663-66-1	100mg	￥50400	2018-12-26	購入
富士フイルム和光純薬株式会社(wako)	W01COBQV-7478	Bedaquiline	843663-66-1	250mg	￥86400	2018-12-26	購入
富士フイルム和光純薬株式会社(wako)	W01COBQV-7478	Bedaquiline	843663-66-1	1g	￥216000	2018-12-26	購入
富士フイルム和光純薬株式会社(wako)	W01TRCB119540	(αS,βR)-Bedaquiline	843663-66-1	50mg	￥370000	2018-12-26	購入
富士フイルム和光純薬株式会社(wako)	W01COBQV-7478	Bedaquiline	843663-66-1	5g	￥648000	2018-12-26	購入

ベダキリン 化学特性,用途語,生産方法

効能

抗結核薬, ATP合成酵素阻害薬

説明

In December 2012, the US FDA approved bedaquiline as part of combination therapy for the treatment of multi-drug resistant tuberculosis (MDRTB). Bedaquiline is the first drug approved for MDR-TB and is the first approval from a new class of antituberculosis agents in the past 40 years. Due to the high unmetmedical need for treating MDR-TB, the FDA granted bedaquiline accelerated approval based on Phase II results, providing patients access to the drug while additional clinical studies are carried out. Bedaquiline (also known as TMC207 and R207910) is a diarylquinoline that was discovered from a high-throughput, whole-cell screening strategy with Mycobacterium smegmatis used as a surrogate for M. tuberculosis. Bedaquiline is a single enantiomer of an initial screening hit. Bedaquiline has potent and selective activity against mycobacteria, and is active against both drug-sensitive and drug-resistant M. tuberculosis. The mechanism of action of bedaquiline is unique amongst anti-TB drugs and involves inhibition of mycobacterial ATP synthase; it is not active against human ATP synthase. Bedaquiline has in vivo activity in numerous preclinical models of TB infection, alone and in combination with other anti-TB agents, and has bactericidal activity in established TB infection models. Bedaquiline is synthesized in five steps from 3-phenylpropionic acid and para-bromoaniline. Following amide formation, treatment with POCl₃ and DMF under Vilsmeier–Hack conditions gave a 2-chloroquinoline product. Treatment with sodium methoxide, followed by condensation with 3-(dimethylamino)-1-(naphthalen-1-yl)propan-1-one, and separation of isomers gave bedaquiline.

使用

(αS,βR)-Bedaquiline is a diarylquinoline derivative that acts as a mycobacterial inhibitor. Bedaquiline shows promise as potential drug in the treatment of tuberculosis.

ベダキリン 上流と下流の製品情報

原材料

準備製品

ベダキリン 生産企業

名前	電話番号	電子メール	国籍	製品カタログ	優位度
shandong perfect biotechnology co.ltd	+86-53169958659; +8618596095638	sales@sdperfect.com	China	294	58
Henan Fengda Chemical Co., Ltd	+86-371-86557731 +86-13613820652	info@fdachem.com	China	7332	58
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21695	55
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	32480	60
Lianyungang happen teng technology co., LTD	15950718863	wang666xt@163.com	CHINA	295	58
career henan chemical co	+86-0371-86658258	sales@coreychem.com	China	29914	58
Biochempartner	0086-13720134139	candy@biochempartner.com	CHINA	967	58
Jinan Carbotang Biotech Co.,Ltd.	+8615866703830	figo.gao@foxmail.com	China	6992	58
BOC Sciences	+1-631-485-4226	inquiry@bocsci.com	United States	19553	58
Chongqing Chemdad Co., Ltd	+86-023-61398051 +8613650506873	sales@chemdad.com	China	39916	58

843663-66-1(ベダキリン)キーワード:

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• 843663-66-1
• TMC-207
• R 207910
• Bedaquiline(R 207910,TMC 207)
• Bedaquiline (TMC-207)
• (αS,βR)-Bedaquiline
• bedaquinline
• (1R,2S)-1-(6-bromo-2-methoxyquinolin-3-yl)-4-(methylamino)-2-(naphthalen-1-yl)-1-phenylbutan-2-ol
• Bedaquiline D6
• (1R)-(6-Bromo-2-methoxyquinolin-3-yl)-4-(dimethylamino)-2(S)-(1-naphthyl)-1-phenylbutan-2-ol
• (1R,2S)-1-(6-BroMo-2-Methoxyquinolin-3-yl)-4-(diMethylaMino)-2-(naphthalen-1-yl)-1-phenylbutan-2-ol
• (αS,βR)-6-Bromo-α-[2-(dimethylamino)ethyl]-2-methoxy-α-1-naphthalenyl-β-phenyl-3-quinolineethanol
• 141027
• TMC-207(Bedaquiline)
• CS-751
• BEDAQUILINE;TMC207;R207910;TMC 207;R 207910;TMC-207;R-207910
• TMC-207 USP/EP/BP
• BEDAQUILINE (TMC207, R207910)
• (1R)-(6-Bromo-2-methoxyquinolin-3-yl)-4-(dimethylamino)-2(S)...
• Bedaquiline D6Q: What is Bedaquiline D6 Q: What is the CAS Number of Bedaquiline D6 Q: What is the storage condition of Bedaquiline D6 Q: What are the applications of Bedaquiline D6
• BedaquilineQ: What is Bedaquiline Q: What is the CAS Number of Bedaquiline Q: What is the storage condition of Bedaquiline Q: What are the applications of Bedaquiline
• Bedaquiline
• Sirturo
• 6-Bromo-alpha-[2-(dimethylamino)ethyl]-2-methoxy-alpha-1-naphthalenyl-beta-phenyl-3-quinolineethanol
• 1-(6-Bromo-2-methoxy-quinolin-3-yl)-4-dimethylamino-2-naphthalen-1-yl-1-phenyl-butan-2-ol
• 3-Quinolineethanol, 6-bromo-alpha-(2-(dimethylamino)ethyl)-2-methoxy-alpha-1-naphthalenyl-beta-phenyl-, (alphas,betar)-
• 3-Quinolineethanol, 6-bromo-α-[2-(dimethylamino)ethyl]-2-methoxy-α-1-naphthalenyl-β-phenyl-, (αS,βR)-
• (αS,βR)-Bedaquiline
• Bedaquline Fumarate
• (alphaS,betaR)-Bedaquiline
• (αS,βR)-6-Bromo-α-[2-(dimethylamino)ethyl]-2-methoxy-α-1-naphthalenyl-β-phenyl-3-quinolineethanol
• ベダキリン
• (1R,2S)-1-(2-メトキシ-6-ブロモ-3-キノリル)-1-フェニル-2-(1-ナフチル)-4-(メチルアミノ)ブタン-2-オール
• (1R,2S)-1-(6-ブロモ-2-メトキシキノリン-3-イル)-4-(メチルアミノ)-2-(ナフタレン-1-イル)-1-フェニルブタン-2-オール
• (1R,2S)-1-フェニル-1-(2-メトキシ-6-ブロモキノリン-3-イル)-2-(1-ナフチル)-4-(ジメチルアミノ)ブタン-2-オール
• R-207910
• (1R,2S)-1-(2-メトキシ-6-ブロモ-3-キノリニル)-1-フェニル-2-(1-ナフチル)-4-(ジメチルアミノ)-2-ブタノール
• (1R,2S)-1-(6-ブロモ-2-メトキシキノリン-3-イル)-4-(ジメチルアミノ)-2-(ナフタレン-1-イル)-1-フェニルブタン-2-オール
• (1R,2S)-4-(ジメチルアミノ)-2-(1-ナフチル)-1-フェニル-1-(2-メトキシ-6-ブロモキノリン-3-イル)ブタン-2-オール