オキサプロジン 化学特性,用途語,生産方法
外観
白色～うすい黄色、結晶～結晶性粉末
溶解性
メタノール及びエタノール(95)にやや溶けにくく、水にほとんど溶けない。
用途
プロピオン酸系化合物です。
シクロオキシゲナーゼ（COX）を阻害し、プ
ロスタグランジン生合成抑制作用を示します。
効能
鎮痛薬, 抗炎症薬, シクロオキシゲナーゼ阻害薬
商品名
アルボ (大正製薬)
使用上の注意
光によって徐々に変化する。
説明
Oxaprozin is a non-steroidal antiinflammatory agent indicated for use in various
forms of rheumatoid arthritis, osteoarthritis, and ankylosing spondylitis. A long
T
1/2 allows once/twice daily dosing. Structurally it is somewhat unique, being a 3-
substituted, rather than a 2-substituted propionic acid.
化学的特性
White Solid
使用
Oxaprozin is an anti-inflammatory drug. Oxaprozin was comparable to Aspirin (A687780).
定義
ChEBI: A monocarboxylic acid that is a propionic acid derivative having a 4,5-diphenyl-1,3-oxazol-2-yl substituent at position 3. It is non-steroidal anti-inflammatory drug commonly used to relieve the pain and inflammatory responses associated with osteoarthrit
s and rheumatoid arthritis.
適応症
Oxaprozin (Daypro) is approved for the treatment
of osteoarthritis and rheumatoid arthritis. Its long halflife
allows for once daily dosing.The most frequently reported
adverse effects of this drug are nausea, vomiting,
and dyspepsia.
一般的な説明
Oxaprozin, 4,5-diphenyl-2-oxazolepropionic acid (Daypro),differs from the other members of this group in being anarylpropionic acid derivative. It shares the same propertiesand side effects of other members in this group. It is indicatedfor the short- and long-term management of OA andRA, administered as a once-daily dose of 600- to 1,200-mgdose because of its long duration of action.
薬物動態学
Oxaprozin is well absorbed (100%) following oral administration, but maximum plasma concentrations are not reached
until 3 to 5 hours following ingestion. Oxaprozin is an anti-inflammatory agent possessing a rapid onset of action and
a prolonged duration of action. In both the carrageenan raw paw edema assay and analgetic tests, it was equipotent
with aspirin. Oxaprozin has been associated with the appearance of rash and/or mild photosensitivity. Some patients
experience an increased incidence of rash on sun-exposed skin during clinical testing.
安全性プロファイル
Poison by ingestion, intravenous, and intraperitoneal routes. Moderately toxic by subcutaneous route. An experimental teratogen. Experimental reproductive effects. An anti-inflammatory agent. When heated to decomposition it emits toxic fumes of NOx.
オキサプロジン 上流と下流の製品情報
原材料
準備製品