OLIGOMYCIN A

 化学構造式
14104-19-9
CAS番号.
14104-19-9
化学名:
别名:
英語名:
OLIGOMYCIN A
英語别名:
OLIGOMYCIN A;OLIGOMYCIN COMPLEX;OLIGOMYCIN, STREPTOMYCES DIASTATOCHROMOGENES;OLIGOMYCIN A, STREPTOMYCES DIASTATOCHROMOGENES
CBNumber:
CB1274064
化学式:
C45H74O11
分子量:
791.06
MOL File:
14104-19-9.mol

OLIGOMYCIN A 物理性質

貯蔵温度 :
−20°C

安全性情報

主な危険性  Xn
Rフレーズ  22
WGK Germany  3
RTECS 番号 RK3325000
3-10

OLIGOMYCIN A 価格

メーカー 製品番号 製品説明 CAS番号 包装 価格 更新時間 購入

OLIGOMYCIN A 化学特性,用途語,生産方法

酵素阻害剤

These macrolide antibiotics from Streptomyces diastatochromogenes have three major members: Oligomycin A (FW = 791.08 g/mol; CAS 14104-19- 9), Oligomycin B (FW = 805.06 g/mol; CAS 11050-94-5), and Oligomycin C (FW = 775.08 g/mol; CAS 11052-72-5). Others include Oligomycin D (also known as rutamycin; FW = 777.05 g/mol; CAS 1404-59-7), Rutamycin B (isolated from Streptomyces aureofaciens (See also Rutamycin) ), and Oligomycin E (FW = 822.07 g/mol; CAS 110231-34-0; isolated from Streptomyces sp. MCI-2225). Primary Mode of Inhibitory Action: The oligomycins inhibit the ATP synthesis activity of the mitochondrial FoF1 ATP synthase, defining the “o” (not 0) in the first subscript. The ATPase activity of the isolated F1 complex is unaffected by oligomycins, unlike the Fo portion. Oligomycin-sensitivity conferring ptrotein (OSCP) interacts with other components in the ATP synthase complex and facilitates oligomycin’s binding to the Fo unit. The Fo complex is, in fact, an integral membrane protein that functions as a proton channel. Other Actions: Oligomycins also inhibit Na+/K+-exchanging ATPases that transport sodium ions from the inside to the outside of animal cells while translocating potassium ions in the reverse direction with the concomitant hydrolysis of ATP. Oligomycin inhibits Na+ translocation in vivo (i.e., the enzyme activity is inhibited by stabilizing the Na occlusion but not the K occlusion). Other Properties: The oligomycins are slightly soluble in water (e.g., oligomycin A has a solubility of 2 μg per 100 mL at 25°C) and are considerable more soluble in water-miscible solvents such as ethanol, acetone, and glacial acetic acid. Target (s) : aldehyde oxidase; ammonia kinase; apyrase, membrane-bound; ATP synthase, or FoF1 ATP synthas; calcidiol 1-monooxygenase; copper-exporting ATPase, partially inhibited; endopeptidase La, weakly inhibited; H+-transporting ATPase, lysosomal; Na+/K+-exchanging ATPase (24- 32); nucleoside triphosphatase; photophosphorylation in Rhodospirillum rubrum; xenobiotic-transporting ATPases.

OLIGOMYCIN A 上流と下流の製品情報

原材料

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OLIGOMYCIN A 生産企業

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