繊維芽細胞増殖因子(FGF) 化学特性,用途語,生産方法
定義
本品は、大腸菌 E.coli によって産生させた単鎖の遺伝子組換ヒトペプチドである。出発遺伝子は、塩基性線維芽細胞成長因子のコードを持つヒト細胞から直接単離されたものである。塩基性線維芽細胞成長因子は、ジスルフィド結合と糖鎖付加の両方またはいずれか一方を含む最大で210個のアミノ酸からなり、固有のアミノ酸配列を持つ。
化粧品の成分用途
皮膚コンディショニング剤、皮膚保護剤
特長
≪アニマルフリーサイトカイン≫ 培養の過程で動物原料を使用していません。
使用上の注意
本品は微量のため内容物を視認できないことがあります。蓋を開ける前は必ず遠心して下さい。
使用
Fibroblast growth factor-basic (FGF-Basic) is required for the maintenance of human embryonic stem cells in culture, and various other stem cell lines, such as mesenchymal stem (stroma) cells (MSC).
一般的な説明
Fibroblast growth factor-basic (FGF-Basic) is found in basement membranes and sub-endothelial extracellular matrix. FGF-Basic is induced early in the development of the embryo where it is necessary (but not sufficient) for pluripotency and self-renewal of embryonic stem cells (ESC) and lineage defined stem cells; wherein it functions to support proliferation and inhibit differentiation. Self-renewal of hESC depends upon activation of the Activin/Nodal/Smad2,3 branch and suppression of the BMP/GDF/Smad5 branch of the TGFβ-family cell signaling program. FGF-Basic is a competence factor for Nodal support of pluripotency. Activin-A is necessary and sufficient to maintain stemness. It induces the expression of both Nodal and FGF-Basic in human ES cells.
Biochem/physiol Actions
FGF2 (fibroblast growth factor 2, also referred to as BFGF (basic fibroblast growth factor)) interacts with FGFR1 (fibroblast growth factor receptor 1), FGFR2 and FGFR3. It stimulates the proliferation of a wide variety of cells including mesenchymal, neuroectodermal and endothelial cells. FGF2 also determines the fate of neural precursor cells and promotes neuronal axon regeneration. It plays an important role in spinal cord injury repair. FGF2 is known to stimulate angiogenesis and is associated with cancer development. High levels of FGF2 are present in the kidney of children with HIV (human immunodeficiency virus)-renal diseases. The FGF2 mRNA is a target of miRNA miR-503.
繊維芽細胞増殖因子(FGF) 上流と下流の製品情報
原材料
準備製品