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2,4-Thiazolidinedione,5-(1,3-benzodioxol-5-ylmethylene)-

化学構造式
6318-41-8
CAS番号.
6318-41-8
化学名:
别名:
英語名:
2,4-Thiazolidinedione,5-(1,3-benzodioxol-5-ylmethylene)-
英語别名:
PI 3-Kγ Inhibitor VII - CAS 6318-41-8 - Calbiochem;2,4-Thiazolidinedione,5-(1,3-benzodioxol-5-ylmethylene)-;5-(Benzo[d][1,3]dioxol-5-ylmethylene)thiazolidine-2,4-dione;Inhibitor,PI3Kγ,inhibit,Phosphoinositide 3-kinase,AS 041164,AS-041164,anti-inflammatory,neutrophil,recruitment,AS041164,RANTES,PI3K
CBNumber:
CB13232856
化学式:
C11H7NO4S
分子量:
249.24
MOL File:
6318-41-8.mol

2,4-Thiazolidinedione,5-(1,3-benzodioxol-5-ylmethylene)- 物理性質

比重(密度) :
1.595±0.06 g/cm3(Predicted)
貯蔵温度 :
+2C to +8C
溶解性:
DMSO に可溶 (最大 25 mg/ml)。
外見 :
黄色の固体
酸解離定数(Pka):
7.13±0.20(Predicted)
色:
黄色
安定性：:
-20°C の DMSO 溶液で最大 3 か月間保存できます。

安全性情報

2,4-Thiazolidinedione,5-(1,3-benzodioxol-5-ylmethylene)- 価格

メーカー 製品番号 製品説明 CAS番号 包装 価格 更新時間 購入

2,4-Thiazolidinedione,5-(1,3-benzodioxol-5-ylmethylene)- 化学特性,用途語,生産方法

説明

The phosphatidylinositol 3-kinases (PI3Ks) are lipid and protein kinases involved in diverse biological processes, including cell growth, migration, and metabolism. AS-041164 is a potent inhibitor of PI3K with selectivity for the class IB isoform PI3Kγ (IC50 = 70 nM), compared to PI3Kα (IC50 = 240 nM), PI3Kβ (IC50 = 1.45 μM), and PI3Kδ (IC50 =1.70 μM). When tested at 1.0 μM, it shows little or no activity against 38 other common kinases. When given orally to mice, AS-041164 shows a pharmacokinetic profile that is similar to the general PI3K inhibitor LY294002 but is three times more potent (ED50 = 27.4 mg/kg for AS-041164 versus 81.6 mg/kg for LY294002) in blocking neutrophil recruitment induced by RANTES.

2,4-Thiazolidinedione,5-(1,3-benzodioxol-5-ylmethylene)- 上流と下流の製品情報

原材料

準備製品

2,4-Thiazolidinedione,5-(1,3-benzodioxol-5-ylmethylene)- 生産企業

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6318-41-8()キーワード:

オキサプロジン 3-[2-(2-ピリジル)-6-(2,3,4,5-テトラヒドロ-1H-3-ベンゾアゼピン-3-イル)ピリミジン-4-イルアミノ]プロピオン酸 アンレキサノクス ロリプラム 6-アミノ-3-メチル-3H-プリン (1S)-1,6bβ,7,8,9a,10,11,11b-オクタヒドロ-11β-アセチルオキシ-1-(メトキシメチル)-9aα,11bα-ジメチル-3H-フロ[4,3,2-de]インデノ[4,5-h]-2-ベンゾピラン-3,6,9-トリオン 2-モルホリノ-8-フェニルクロモン
  • 6318-41-8
  • 2,4-Thiazolidinedione,5-(1,3-benzodioxol-5-ylmethylene)-
  • PI 3-Kγ Inhibitor VII - CAS 6318-41-8 - Calbiochem
  • Inhibitor,PI3Kγ,inhibit,Phosphoinositide 3-kinase,AS 041164,AS-041164,anti-inflammatory,neutrophil,recruitment,AS041164,RANTES,PI3K
  • 5-(Benzo[d][1,3]dioxol-5-ylmethylene)thiazolidine-2,4-dione
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