Cefditoren Pivoxil Dimer

 化学構造式
CAS番号.
化学名:
别名:
英語名:
Cefditoren Pivoxil Dimer
英語别名:
Cefditoren Pivoxil Dimer
CBNumber:
CB13370116
化学式:
分子量:
0
MOL File:
Mol file

Cefditoren Pivoxil Dimer 物理性質

安全性情報

Cefditoren Pivoxil Dimer 価格

メーカー 製品番号 製品説明 CAS番号 包装 価格 更新時間 購入

Cefditoren Pivoxil Dimer 化学特性,用途語,生産方法

使用

(E)-Cefditoren Pivoxil Dimer is derivative of Cefditoren Pivoxil. Cefditoren Pivoxil is an antibacterial. Third generation cephalosporin.

製造方法

The preparation (scheme 1) starts from Cefditoren pivoxil (24.83g, 0.04mol), formalin (3.48g, mass fraction are 37%~40%) and sulfuric acid (0.12g, 1.2mmol), which is added in acetonitrile (125mL), and keeping the temperature 80℃ for 2.0h, then the reaction solution is cooled down to room temperature. The solution is added the mixture of purified water (100mL) and ethyl acetate (200mL) and keep stirring 10min after liquid separation. After being filtered, purified and recrystallized, the finished dimer was got with yield 87.6%.
1.jpg
Scheme 1 The synthesis of Cefditoren Pivoxil Dimer
Zhangying and his coworkers developed another method to cefditoren pivoxil dimer.
2.jpg
Scheme 2 The synthesis of Cefditoren Pivoxil Dimer
Scheme 2 shows the reaction mechanism. First, the cephem compounds (1) nucleophilic attack of the amino Vilsmeier reagent (1), to generate intermediate (3); another molecule cephem compound (I) followed by nucleophilic attack of the amino group resulting intermediate (3) to generate intermediate (5); and then the intermediate (5) dimethylamine off, to form the intermediate (6), the generates the desired products (7) by the transfer of hydrogen ions.

Cefditoren Pivoxil Dimer 上流と下流の製品情報

原材料

準備製品


Cefditoren Pivoxil Dimer 生産企業

Global( 3)Suppliers
名前 電話番号 電子メール 国籍 製品カタログ 優位度
Guangzhou PI PI Biotech Inc +86-020-81716320 +86-18371201331
Sales@pipitech.com China 3635 55
PI & PI BIOTECH INC. 020-81716320 18371201331
Sales@pipitech.com China 2649 58
Guangzhou Longying Biotechnology Co., Ltd. 15975567350 15975567350
loninbio@sohu.com China 474 58

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