オレイルアルコール 化学特性,用途語,生産方法
外観
無色～わずかにうすい黄色, 澄明の液体
定義
本品は、オリーブ油(*)から得られた脂肪酸を還元した脂肪族アルコールである。参照表示名称：オリーブ油
溶解性
水に不溶, エタノール, エーテルに可溶。エタノールに溶け、水にほとんど溶けない。
用途
有機合成原料。
原料由来
液状高級脂肪酸/液状高級アルコール（植物系のみ）
化粧品の成分用途
エモリエント剤、非水系増粘剤、溶剤、乳化安定剤、香料
効能
軟化剤, 乳化剤
特徴
植物由来の不飽和アルコール。
化学的特性
Oleyl alcohol occurs as a pale yellow oily liquid that gives off acrid
fumes when heated.
使用
oleyl alcohol is an emollient, solvent, viscosity-increasing agent, and carrier employed in a wide variety of cosmetic formulations including makeup, skin care, and hand and body preparations. oleyl alcohol is an unsaturated fatty alcohol found in fish oils and can also be produced synthetically. According to some sources, it is comedogenic and has a mild irritancy potential.
調製方法
Oleyl alcohol occurs naturally in fish oils. Synthetically, it can be
prepared from butyl oleate by a Bouveault–Blanc reduction with
sodium and butyl alcohol. An alternative method of manufacture is
by the hydrogenation of triolein in the presence of zinc chromite.
定義
ChEBI: A long chain fatty alcohol that is octadecanol containing a double bond located at position 9 (the Z-geoisomer).
一般的な説明
Oleyl alcohol has been reported as an effective solvent for oil/water-type tacrolimus (FK506) cream formulation, useful for atopic dermatitis treatment. It was reported as diluting agent for Alamine 336. Palm oil esters derived from oleyl alcohol, have potential applications in the cosmetic and pharmaceutical industries due to the excellent wetting behavior of the esters without the oily feel.
応用例（製薬）
Oleyl alcohol is mainly used in topical pharmaceutical formulations
and has been used in transdermal delivery formulations.It has
been utilized in the development of biodegradable injectable
thermoplastic oligomers,and in aerosol formulations of insulin
and albuterol.
Therapeutically, it has been suggested that oleyl alcohol may
exhibit antitumor properties via transmembrane permeation.
安全性プロファイル
A human skin and eye irritant. Aningredient in cosmetics. When heated to decomposition itemits acrid smoke and irritating fumes.
安全性
Oleyl alcohol is mainly used in topical pharmaceutical formulations
and is generally regarded as a nontoxic and nonirritant material at
the levels employed as an excipient. However, contact dermatitis
due to oleyl alcohol has been reported.
The results of acute oral toxicity and percutaneous studies in
animals with products containing 8% oleyl alcohol indicate a very
low toxicity. Formulations containing 8% or 20% oleyl alcohol
administered by gastric intubation, at doses up to 10 g/kg bodyweight,
caused no deaths and no toxic effects in rats.
貯蔵
The bulk material should be stored in a well-closed container in a
cool, dry, place.
純化方法
Purify it by fractional crystallisation at -40o from acetone, then distil it under vacuum. [Beilstein 2 IV 2204.]
規制状況(Regulatory Status)
Included in the FDA Inactive Ingredients Database (topical
emulsions and ointments). Included in nonparenteral medicines
licensed in the UK. Included in the Canadian List of Acceptable
Non-medicinal Ingredients.
オレイルアルコール 上流と下流の製品情報
原材料
準備製品