4-アミノ-m-クレゾール 化学特性,用途語,生産方法
外観
白色〜褐色, 結晶性粉末
溶解性
水、エタノール及びアセトンに溶ける。
用途
有機合成原料。
説明
4-Amino-3-methylphenol is a metabolite of 3-methyl-4-nitrophenol. It is a major metabolite of carcinogenic o-toluidine and causes DNA damage in the presence of Cu(II).
化学的特性
Light gray powder
使用
4-Amino-3-methylphenol is a useful reagent for the synthesis of piperidine (piperazine)-amide substituted derivatives as multi-target antipsychotics.
4-Amino-3-methylphenol was used in synthesis of a new type of tweezer-molecule in which a strongly preferred binding conformation is generated by convergent, intramolecular hydrogen bonding.
定義
ChEBI: A substituted aniline in which the aniline ring carries 4-hydroxy and 6-methyl substituents; a urinary metabolite of lidocaine.
主な応用
4-Amino-m-cresol is used as an oxidative hair dye at a maximum concentration of 1.5% after mixing with peroxide.
一般的な説明
4-Amino-3-methylphenol is a metabolite of 3-methyl-4-nitrophenol. It is a major metabolite of carcinogenic
o-toluidine and causes DNA damage in the presence of Cu(II).
合成
The synthesis of 4-Amino-3-methylphenol is as follows:A mixture of the para-benzoquinone mono-oxime (1.26 mmol),SnCl
2 (0.72 g, 3.80 mmol), 20 mL of CH
2Cl
2, and 0.2 mL of concentrated HCl, was heated to reflux for 16 h. The CH
2Cl
2 was removed under reduced pressure, and the residue was dissolved in ethyl acetate and washed with concentrated aqueous NaHCO
3. The organic layer was dried over anhydrous Na
2SO
4 and the filtrate was concentrated under reduced pressure to afford the solid product.
純化方法
Crystallise it from 50% EtOH. [Beilstein 13 H 593, 13 IV 1698.]
4-アミノ-m-クレゾール 上流と下流の製品情報
原材料
準備製品