2-フロイル-LIGRLO-アミド
2-フロイル-LIGRLO-アミド 物理性質
- 比重(密度) :
- 1.33±0.1 g/cm3(Predicted)
- 貯蔵温度 :
- -20°C
- 溶解性:
- Soluble in H2O
- 外見 :
- 粉
- 酸解離定数(Pka):
- 12.91±0.46(Predicted)
- 色:
- 白い
- 水溶解度 :
- Soluble to 1 mg/ml in water
2-フロイル-LIGRLO-アミド 価格
もっと(4)
| メーカー |
製品番号 |
製品説明 |
CAS番号 |
包装 |
価格 |
更新時間 |
購入 |
|
富士フイルム和光純薬株式会社(wako)
|
W01BCS4048620 |
(2-Furoyl)-PAR-2 (2-6)-Orn amide (mouse, rat), (2-Furoyl)-Leu-Ile-Gly-Arg-Leu-Orn-NH2, Trifluoroacetate |
729589-58-6 |
5mg |
￥79000 |
2024-03-01 |
購入 |
|
富士フイルム和光純薬株式会社(wako)
|
W01BCS4048620 |
(2-Furoyl)-PAR-2 (2-6)-Orn amide (mouse, rat), (2-Furoyl)-Leu-Ile-Gly-Arg-Leu-Orn-NH2, Trifluoroacetate |
729589-58-6 |
25mg |
￥315000 |
2024-03-01 |
購入 |
|
Sigma-Aldrich Japan
|
F3681 |
2-フロイル-LIGRLO-アミド トリフルオロアセタート塩 ≥97% (HPLC)
2-Furoyl-LIGRLO-amide trifluoroacetate salt ≥97% (HPLC) |
729589-58-6 |
1mg |
￥23800 |
2024-03-01 |
購入 |
|
富士フイルム和光純薬株式会社(wako)
|
W01TOC3015 |
2-フロイル-LIGRLO-アミド
2-Furoyl-LIGRLO-amide |
729589-58-6 |
1mg |
￥47000 |
2024-03-01 |
購入 |
2-フロイル-LIGRLO-アミド 化学特性,用途語,生産方法
使用
2-Furoyl-LIGRLO-amide trifluoroacetate salt may be used as a protease-activated receptor 2 (PAR2) agonist in endothelial progenitor cells (EPCs) and in transient receptor potential cation channel subfamily V member (TRPV4)-transfected HEK293t cells.
一般的な説明
2-Furoyl-LIGRLO-amide trifluoroacetate salt is a peptide that acts as a proteinase-activated receptor-2 (PAR
2) agonist, and contains a furoyl group addition at its N-terminal.
Biochem/physiol Actions
2-Furoyl-LIGRLO-amide is a potent and selective protease-activated receptor 2 (PAR2) agonist. PAR-2 activation is associated with increases in cAMP and intracellular Ca(2+). Immunoblot analysis revealed increases in phosphorylation of epidermal growth factor (EGF) receptor (EGFR) tyrosine kinase, Src, Pyk2, cRaf, and ERK1/2 in response to PAR-2 activation. 2-Furoyl-LIGRLO-amide is nearly 100-fold more potent than SLIGRL-NH2 (Cat. No. S9317). 2-Furoyl-LIGRLO-amide caused both an endothelium-dependent relaxation and an endothelium-independent contraction. It produced delayed (6 hours later) facilitation of capsaicin-evoked visceral nociception, an effect being much more potent than SLIGRL-NH2. Such effects were mimicked by i.col. trypsin. 2-f-LIGRL-NH2, coadministered repeatedly with caerulein six times in total, abolished the caerulein-evoked abdominal hyperalgesia/allodynia in WT, but not PAR2-KO, mice. Repeated doses of 2-f-LIGRL-NH2 moderately attenuated the severity of caerulein-induced pancreatitis in WT animals. It induced a similar dose-dependent increase in Ca2 levels in the presence and absence of b-arrestins.
2-フロイル-LIGRLO-アミド 上流と下流の製品情報
原材料
準備製品
2-フロイル-LIGRLO-アミド 生産企業
Global( 68)Suppliers
729589-58-6(2-フロイル-LIGRLO-アミド)キーワード:
- 729589-58-6
- PAR-2 AGONIST II
- PROTEINASE ACTIVATED RECEPTOR-2 AGONIST II
- 2-(2-FUROYL)-LEU-ILE-GLY-ARG-LEU-ORN-NH2
- 2-(2-FUROYL)-LIGRLOAMIDE
- 2-(2-FUROYL)-PAR-2 (2-6)-ORN AMIDE (MOUSE, RAT)
- 2F-LIGRLO-AMIDE
- 2-FUROYL-LEU-ILE-GLY-ARG-LEU-ORN-NH2
- 2-FUROYL-LIGRLO-AMIDE
- (2-Furoyl)-PAR-2 (2-6)-Orn amide (mouse, rat)
- 2fLI
- 2-f-LIGRLO-NH2
- 2-Fly
- 2-Furoyl-Leu-Ile-Gly-Arg-Leu-Orn-NH2 trifluoroacetate salt
- 2-Furoyl-LIGRLO-amide trifluoroacetate salt
- f-LIGRLO-NH2
- 2-Furoyl-LIGRLO-NH2 Potent and Selective Protease-Activated Receptor 2 (PAR2) Agonist
- L-Ornithinamide, N-(2-furanylcarbonyl)-L-leucyl-L-isoleucylglycyl-L-arginyl-L-leucyl-
- N-(2-Furanylcarbonyl)-L-leucyl-L-isoleucylglycyl-L-arginyl-L-leucyl-L-ornithinamide
- 2-Furoyl-LIGRLO-amid
- 2-Furoyl-LIGRLO-NH2
- Potent and Selective Protease-Activated Receptor2 (PAR2) Agonist
- 2-フロイル-LIGRLO-アミド
- 2-フロイル-LIGRLO-アミド トリフルオロアセタート塩
- (2S,3S)-N-({[(1S)-1-{[(1S)-1-{[(1S)-4-アミノ-1-カルバモイルブチル]カルバモイル}-3-メチルブチル]カルバモイル}-4-カルバムイミドアミドブチル]カルバモイル}メチル)-2-[(2S)-2-[(フラン-2-イル)ホルムアミド]-4-メチルペンタンアミド]-3-メチルペンタンアミド
- N-(フラン-2-イルカルボニル)-Leu-Ile-Gly-Arg-Leu-Orn-NH2