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5'-[[(S)-3-アミノ-3-カルボキシラトプロピル]メチルスルホニオ]-5'-デオキシアデノシン

5'-[[(S)-3-アミノ-3-カルボキシラトプロピル]メチルスルホニオ]-5'-デオキシアデノシン 化学構造式
29908-03-0
CAS番号.
29908-03-0
化学名:
5'-[[(S)-3-アミノ-3-カルボキシラトプロピル]メチルスルホニオ]-5'-デオキシアデノシン
别名:
S-アデノシル-L-メチオニン;メチオニルアデニラート;活性メチオニン;S-アデノシルメチオニン;アデノシルメチオニン;メチオニルアデノシン;アデメチオニン;(5'-アデノシル)[(S)-3-アミノ-3-カルボキシラトプロピル](メチル)スルホニウム;5'-[[(S)-3-アミノ-3-カルボキシラトプロピル]メチルスルホニオ]-5'-デオキシアデノシン
英語化学名:
S-Adenosyl-L-methionine
英語别名:
SAM;SAM-E;SAM-B;Ademetionin;ADEMETIONINE;Ademetionine(b);adenosylmethionine;methioninyladenylate;S-Adenosyl-L-methion;S-ADENOSYL-L-METHIONINE
CBNumber:
CB1384167
化学式:
C15H22N6O5S
分子量:
398.44
MOL File:
29908-03-0.mol

5'-[[(S)-3-アミノ-3-カルボキシラトプロピル]メチルスルホニオ]-5'-デオキシアデノシン 物理性質

貯蔵温度 :
Inert atmosphere,Store in freezer, under -20°C
CAS データベース:
29908-03-0(CAS DataBase Reference)

安全性情報

Rフレーズ  49-23-34
Sフレーズ  53-23-36/37/39-45
HSコード  29349990

5'-[[(S)-3-アミノ-3-カルボキシラトプロピル]メチルスルホニオ]-5'-デオキシアデノシン 価格

メーカー 製品番号 製品説明 CAS番号 包装 価格 更新時間 購入

5'-[[(S)-3-アミノ-3-カルボキシラトプロピル]メチルスルホニオ]-5'-デオキシアデノシン 化学特性,用途語,生産方法

解説

生物界に広く存在し、細胞機能の調節に重要な役割を果たす物質。哺乳類の場合、肝臓でATPとメチオニンから合成され、核酸・リン脂質・ホルモンなどの合成に利用される。S-アデノシルメチオニン。活性メチオニン。
小学館 デジタル大辞泉について 情報 | 凡例

Originator

Donamet ,Ravizza

天然物の起源

SAM-e is found in all living cells and is a precursor in some amino acids.

使用

white powder LOD 0.2%

Manufacturing Process

S-Adenosyl methionine (SAM) is produced is prepared by cultivating of Saccharomyces cerevisiae.
One loopful of each of the microorganism strains (IFO 2342, IFO 2343, IFO 2345, IFO 2346, IFO 2347) was inoculated in 10 ml of a heat-sterilized culture medium adjusted to pH 6.0 and composed of 5.0 g/dl of glucose, 0.5 g/dl of polypeptone, 0.4 g/dl of KH2PO4, 0.4 g/dl of K2HPO4, 0.02 g/dl of MgSO4·7H2O and 0.2 g/dl of yeast extract, and cultivated with shaking at 28°C for 24 h.
1 L of a culture medium adjusted to pH 6.0 and composed of 10.0 g/dl of sucrose, 1.0 g/dl of yeast extract, 0.4 g/dl of K2HPO4, 0.01 g/dl of MgSO4·7H2O, 1.5 g/dl of urea (separately sterilized), 0.75 g/dl of Lmethionine, 0.02 g/dl of CaCl2·2H2O, 0.25 mg/dl of ZnSO4·7H2O, 0.25 mg/dl of FeSO4·7H2O, 125.0 mg/dl of MnSO4·6H2O, 2.0 μg/dl of CuSO4·5H2O, 2.0 μg/dl of H3BO3, 0.2 μg/dl of CoCl2·6H2O and 1.0 μg/dl of KI was put in a 2- liter fermentor and sterilized. Then, 5 ml of the seed culture broth prepared as above was inoculated in the culture medium and cultivated at 28°C for 72 h with aeration and agitation.
After the cultivation, the microbial cells were collected by centrifugal separation, washed once with physiological saline, suspended in 100 ml of 1.5 N perchloric acid, and shaken at room temperature for 1 h. The suspension was then centrifuged to remove the microbial cells, and the resulting liquid was adjusted to pH 4.5 by adding potassium hydrogen carbonate. The resulting precipitate of potassium perchlorate was removed by centrifugal separation to give an extract containing SAM. The amount of SAM in the extract was determined, and the amount of SAM based on the dry cells.
The extract in an amount of 0.2 g as SAM was passed through a column filled with 50 ml of Amberlite IRC-50 (H+ form), a weakly acidic cation exchange resin, to cause adsorption of SAM. 0.005 N acetic acid was passed through the column to wash it until the absorbance at 260 nm of the eluate becames less than 0.1. Thus, impurities were removed. Then, 0.1 N sulfuric acid was passed through the column, and SAM was eluted until the absorbance at 260 nm of the eluate becames less than 0.05. The eluate was treated with Amberlite IRA 900 resin (OH- form) to adjust its pH to 3.0, and then lyophilized to obtain SAM sulfate. The SAM based may be produced from SAM sulfate by treatment with potassium hydrogen carbonate. The purity of SAM was measured by cellulose thin-layer chromatography, paper chromatography and high-performance liquid chromatography. The yield of SAM based on the dry cells: IFO 2343-12.1%; IFO 2346-18.8%; IFO 2347-16.7%.

Therapeutic Function

Metabolic, Antiinflammatory

5'-[[(S)-3-アミノ-3-カルボキシラトプロピル]メチルスルホニオ]-5'-デオキシアデノシン 上流と下流の製品情報

原材料

準備製品


5'-[[(S)-3-アミノ-3-カルボキシラトプロピル]メチルスルホニオ]-5'-デオキシアデノシン 生産企業

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29908-03-0(5'-[[(S)-3-アミノ-3-カルボキシラトプロピル]メチルスルホニオ]-5'-デオキシアデノシン)キーワード:


  • 29908-03-0
  • ADEMETIONINE
  • S-ADENOSYL-L-METHIONINE
  • SAM-E
  • adenosine,5’-((l-3-amino-3-carboxypropyl)methylsulfonio)-5’-deoxy-,hydroxide,
  • adenosylmethionine
  • methioninyladenylate
  • p-Toluenesulfonate salt
  • ADEMETHIOINEDISULFATETOSYLATE
  • (3-amino-3-carboxy-propyl)-[[5-(6-aminopurin-9-yl)-3,4-dihydroxy-oxolan-2-yl]methyl]-methyl-sulfanium
  • (3S)-5'-[(3-Amino-3-carboxylatopropyl)methylsulphonio]-5'-deoxyadenosine
  • SAM
  • S-(5'-desoxyadenosin-5'-y1) methionine
  • (5'-Adenosyl)[(S)-3-amino-3-carboxylatopropyl](methyl)sulfonium
  • 5'-[[(S)-3-Amino-3-carboxylatopropyl]methylsulfonio]-5'-deoxyadenosine
  • S-Adenosyl-L-methion
  • Ademetionin
  • SAM-B
  • S-adenosyl-L-methioninate
  • Ademetionine1,4-Butanedisulfonate for Injection
  • Ademetionine(b)
  • Ademetionine 1,4-Butanedisulfonate Impurity 10
  • S-Adenosyl-L-methionine fandachem
  • S-Adenosyl-L-methionine USP/EP/BP
  • S-アデノシル-L-メチオニン
  • メチオニルアデニラート
  • 活性メチオニン
  • S-アデノシルメチオニン
  • アデノシルメチオニン
  • メチオニルアデノシン
  • アデメチオニン
  • (5'-アデノシル)[(S)-3-アミノ-3-カルボキシラトプロピル](メチル)スルホニウム
  • 5'-[[(S)-3-アミノ-3-カルボキシラトプロピル]メチルスルホニオ]-5'-デオキシアデノシン
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